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PDBsum entry 1pd1
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Transport protein PDB id
1pd1

 

 

 

 

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Contents
Protein chain
735 a.a. *
Ligands
GLN-LEU-LYS-ASP-
LEU-GLU-SER-GLN-
ILE
Metals
_ZN
Waters ×166
* Residue conservation analysis
PDB id:
1pd1
Name: Transport protein
Title: Crystal structure of the copii coat subunit, sec24, complexed with a peptide containing the dxe cargo sorting signal of yeast sys1 protein
Structure: Protein transport protein sec24. Chain: a. Synonym: abnormal nuclear morphology 1. Other_details: sec24 fragment lacking n-terminal residues 1-116. Dxe cargo sorting signal peptide of yeast sys1 protein. Chain: b. Engineered: yes
Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Synthetic: yes. Other_details: the peptide was chemically synthesized. The sequence of the peptide is naturally found in saccharomyces cerevisiae
Biol. unit: Dimer (from PQS)
Resolution:
2.60Å     R-factor:   0.203     R-free:   0.256
Authors: E.Mossessova,L.C.Bickford,J.Goldberg
Key ref: E.Mossessova et al. (2003). SNARE selectivity of the COPII coat. Cell, 114, 483-495. PubMed id: 12941276
Date:
18-May-03     Release date:   19-Aug-03    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P40482  (SEC24_YEAST) -  Protein transport protein SEC24 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
Seq:
Struc: 		 
Seq:
Struc: 		926 a.a.
735 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.?
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

 

 
Cell 114:483-495 (2003)
PubMed id: 12941276  
 
 
SNARE selectivity of the COPII coat.
E.Mossessova, L.C.Bickford, J.Goldberg.
 
  ABSTRACT  
 
The COPII coat buds transport vesicles from the endoplasmic reticulum that incorporate cargo and SNARE molecules. Here, we show that recognition of the ER-Golgi SNAREs Bet1, Sed5, and Sec22 occurs through three binding sites on the Sec23/24 subcomplex of yeast COPII. The A site binds to the YNNSNPF motif of Sed5. The B site binds to Lxx-L/M-E sequences present in both the Bet1 and Sed5 molecules, as well as to the DxE cargo-sorting signal. A third, spatially distinct site binds to Sec22. COPII selects the free v-SNARE form of Bet1 because the LxxLE sequence is sequestered in the four-helix bundle of the v-/t-SNARE complex. COPII favors Sed5 within the Sed5/Bos1/Sec22 t-SNARE complex because t-SNARE assembly removes autoinhibitory contacts to expose the YNNSNPF motif. The COPII coat seems to be a specific conductor of the fusogenic forms of these SNAREs, suggesting how vesicle fusion specificity may be programmed during budding.
 

Literature references that cite this PDB file's key reference

  PubMed id Reference
22193160 G.Zanetti, K.B.Pahuja, S.Studer, S.Shim, and R.Schekman (2012).
COPII and the regulation of protein sorting in mammals.
  Nat Cell Biol, 14, 20-28.  
20643221 C.G.Angers, and A.J.Merz (2011).
New links between vesicle coats and Rab-mediated vesicle targeting.
  Semin Cell Dev Biol, 22, 18-26.  
21291503 C.Kodera, T.Yorimitsu, A.Nakano, and K.Sato (2011).
Sed4p stimulates Sar1p GTP hydrolysis and promotes limited coat disassembly.
  Traffic, 12, 591-599.  
21532587 C.Lord, D.Bhandari, S.Menon, M.Ghassemian, D.Nycz, J.Hay, P.Ghosh, and S.Ferro-Novick (2011).
Sequential interactions with Sec23 control the direction of vesicle traffic.
  Nature, 473, 181-186.  
20817851 C.Zheng, H.H.Liu, S.Yuan, J.Zhou, and B.Zhang (2010).
Molecular basis of LMAN1 in coordinating LMAN1-MCFD2 cargo receptor formation and ER-to-Golgi transport of FV/FVIII.
  Blood, 116, 5698-5706.  
20032308 G.Roy, E.M.Chalfin, A.Saxena, and X.Wang (2010).
Interplay between ER exit code and domain conformation in CFTR misprocessing and rescue.
  Mol Biol Cell, 21, 597-609.  
20533886 J.Dancourt, and C.Barlowe (2010).
Protein sorting receptors in the early secretory pathway.
  Annu Rev Biochem, 79, 777-802.  
20658963 J.Zimmermann, S.Chidambaram, and G.Fischer von Mollard (2010).
Dissecting Ent3p: the ENTH domain binds different SNAREs via distinct amino acid residues while the C-terminus is sufficient for retrograde transport from endosomes.
  Biochem J, 431, 123-134.  
21054154 K.E.Routledge, V.Gupta, and W.E.Balch (2010).
Emergent properties of proteostasis-COPII coupled systems in human health and disease.
  Mol Membr Biol, 27, 385-397.  
20200224 P.Shindiapina, and C.Barlowe (2010).
Requirements for transitional endoplasmic reticulum site structure and function in Saccharomyces cerevisiae.
  Mol Biol Cell, 21, 1530-1545.  
20477990 R.Buchanan, A.Kaufman, L.Kung-Tran, and E.A.Miller (2010).
Genetic analysis of yeast Sec24p mutants suggests cargo binding is not co-operative during ER export.
  Traffic, 11, 1034-1043.  
21079008 R.Schekman (2010).
Charting the secretory pathway in a simple eukaryote.
  Mol Biol Cell, 21, 3781-3784.  
20442775 S.Sarmah, A.Barrallo-Gimeno, D.B.Melville, J.Topczewski, L.Solnica-Krezel, and E.W.Knapik (2010).
Sec24D-dependent transport of extracellular matrix proteins is required for zebrafish skeletal morphogenesis.
  PLoS One, 5, e10367.  
19183188 B.Zhang (2009).
Recent developments in the understanding of the combined deficiency of FV and FVIII.
  Br J Haematol, 145, 15-23.  
19574229 C.A.Bue, and C.Barlowe (2009).
Molecular dissection of Erv26p identifies separable cargo binding and coat protein sorting activities.
  J Biol Chem, 284, 24049-24060.  
19759175 E.S.Sevova, and J.D.Bangs (2009).
Streamlined architecture and glycosylphosphatidylinositol-dependent trafficking in the early secretory pathway of African trypanosomes.
  Mol Biol Cell, 20, 4739-4750.  
19497047 J.Dancourt, and C.Barlowe (2009).
Erv26p-dependent export of alkaline phosphatase from the ER requires lumenal domain recognition.
  Traffic, 10, 1006-1018.  
19526556 K.Sakai, R.Hamanaka, H.Yuki, and M.Watanabe (2009).
A novel fractionation method of the rough ER integral membrane proteins; resident proteins versus exported proteins?
  Proteomics, 9, 3036-3046.  
19561605 K.Schwarz, A.Iolascon, F.Verissimo, N.S.Trede, W.Horsley, W.Chen, B.H.Paw, K.P.Hopfner, K.Holzmann, R.Russo, M.R.Esposito, D.Spano, L.De Falco, K.Heinrich, B.Joggerst, M.T.Rojewski, S.Perrotta, J.Denecke, U.Pannicke, J.Delaunay, R.Pepperkok, and H.Heimpel (2009).
Mutations affecting the secretory COPII coat component SEC23B cause congenital dyserythropoietic anemia type II.
  Nat Genet, 41, 936-940.  
19763084 K.V.Tabata, K.Sato, T.Ide, T.Nishizaka, A.Nakano, and H.Noji (2009).
Visualization of cargo concentration by COPII minimal machinery in a planar lipid membrane.
  EMBO J, 28, 3279-3289.  
19516076 L.Chatre, V.Wattelet-Boyer, S.Melser, L.Maneta-Peyret, F.Brandizzi, and P.Moreau (2009).
A novel di-acidic motif facilitates ER export of the syntaxin SYP31.
  J Exp Bot, 60, 3157-3165.  
19659502 M.Mikosch, K.Käberich, and U.Homann (2009).
ER export of KAT1 is correlated to the number of acidic residues within a triacidic motif.
  Traffic, 10, 1481-1487.  
19000162 S.L.Hanton, L.A.Matheson, L.Chatre, and F.Brandizzi (2009).
Dynamic organization of COPII coat proteins at endoplasmic reticulum export sites in plant cells.
  Plant J, 57, 963-974.  
19487677 S.V.Barysch, S.Aggarwal, R.Jahn, and S.O.Rizzoli (2009).
Sorting in early endosomes reveals connections to docking- and fusion-associated factors.
  Proc Natl Acad Sci U S A, 106, 9697-9702.  
19357197 T.K.Taneja, J.Mankouri, R.Karnik, S.Kannan, A.J.Smith, T.Munsey, H.B.Christesen, D.J.Beech, and A.Sivaprasadarao (2009).
Sar1-GTPase-dependent ER exit of KATP channels revealed by a mutation causing congenital hyperinsulinism.
  Hum Mol Genet, 18, 2400-2413.  
17973654 H.Higashio, K.Sato, and A.Nakano (2008).
Smy2p participates in COPII vesicle formation through the interaction with Sec23p/Sec24p subcomplex.
  Traffic, 9, 79-93.  
18060556 H.Hughes, and D.J.Stephens (2008).
Assembly, organization, and function of the COPII coat.
  Histochem Cell Biol, 129, 129-151.  
18764818 J.Bubeck, D.Scheuring, E.Hummel, M.Langhans, C.Viotti, O.Foresti, J.Denecke, D.K.Banfield, and D.G.Robinson (2008).
The syntaxins SYP31 and SYP81 control ER-Golgi trafficking in the plant secretory pathway.
  Traffic, 9, 1629-1652.  
18534853 J.C.Fromme, L.Orci, and R.Schekman (2008).
Coordination of COPII vesicle trafficking by Sec23.
  Trends Cell Biol, 18, 330-336.  
18843296 J.D.Mancias, and J.Goldberg (2008).
Structural basis of cargo membrane protein discrimination by the human COPII coat machinery.
  EMBO J, 27, 2918-2928.
PDB codes: 3efo 3eg9 3egd 3egx 3eh1 3eh2
18532879 K.E.Süel, H.Gu, and Y.M.Chook (2008).
Modular organization and combinatorial energetics of proline-tyrosine nuclear localization signals.
  PLoS Biol, 6, e137.  
18410493 M.C.Lee, P.A.Moura, E.A.Miller, and D.A.Fidock (2008).
Plasmodium falciparum Sec24 marks transitional ER that exports a model cargo via a diacidic motif.
  Mol Microbiol, 68, 1535-1546.  
18775314 P.R.Pryor, L.Jackson, S.R.Gray, M.A.Edeling, A.Thompson, C.M.Sanderson, P.R.Evans, D.J.Owen, and J.P.Luzio (2008).
Molecular basis for the sorting of the SNARE VAMP7 into endocytic clathrin-coated vesicles by the ArfGAP Hrb.
  Cell, 134, 817-827.
PDB code: 2vx8
18981232 S.A.Baker, M.Haeri, P.Yoo, S.M.Gospe, N.P.Skiba, B.E.Knox, and V.Y.Arshavsky (2008).
The outer segment serves as a default destination for the trafficking of membrane proteins in photoreceptors.
  J Cell Biol, 183, 485-498.  
17618120 A.C.Baines, and B.Zhang (2007).
Receptor-mediated protein transport in the early secretory pathway.
  Trends Biochem Sci, 32, 381-388.  
17371760 E.A.Miller (2007).
Vesicle tethering: TRAPPing transport carriers.
  Curr Biol, 17, R211-R213.  
17210573 H.Farhan, V.Reiterer, V.M.Korkhov, J.A.Schmid, M.Freissmuth, and H.H.Sitte (2007).
Concentrative export from the endoplasmic reticulum of the gamma-aminobutyric acid transporter 1 requires binding to SEC24D.
  J Biol Chem, 282, 7679-7689.  
17981132 J.C.Fromme, M.Ravazzola, S.Hamamoto, M.Al-Balwi, W.Eyaid, S.A.Boyadjiev, P.Cosson, R.Schekman, and L.Orci (2007).
The genetic basis of a craniofacial disease provides insight into COPII coat assembly.
  Dev Cell, 13, 623-634.  
17499046 J.D.Mancias, and J.Goldberg (2007).
The transport signal on Sec22 for packaging into COPII-coated vesicles is a conformational epitope.
  Mol Cell, 26, 403-414.
PDB codes: 2nup 2nut
18056412 J.Kim, B.Kleizen, R.Choy, G.Thinakaran, S.S.Sisodia, and R.W.Schekman (2007).
Biogenesis of gamma-secretase early in the secretory pathway.
  J Cell Biol, 179, 951-963.  
17428919 L.P.Sun, J.Seemann, J.L.Goldstein, and M.S.Brown (2007).
Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins.
  Proc Natl Acad Sci U S A, 104, 6519-6526.  
17686639 M.C.Lee, and E.A.Miller (2007).
Molecular mechanisms of COPII vesicle formation.
  Semin Cell Dev Biol, 18, 424-434.  
17255961 M.W.Wendeler, J.P.Paccaud, and H.P.Hauri (2007).
Role of Sec24 isoforms in selective export of membrane proteins from the endoplasmic reticulum.
  EMBO Rep, 8, 258-264.  
17547699 M.Zuzarte, S.Rinné, G.Schlichthörl, A.Schubert, J.Daut, and R.Preisig-Müller (2007).
A di-acidic sequence motif enhances the surface expression of the potassium channel TASK-3.
  Traffic, 8, 1093-1100.  
17428924 R.Schekman (2007).
How sterols regulate protein sorting and traffic.
  Proc Natl Acad Sci U S A, 104, 6496-6497.  
18033301 S.E.Miller, B.M.Collins, A.J.McCoy, M.S.Robinson, and D.J.Owen (2007).
A SNARE-adaptor interaction is a new mode of cargo recognition in clathrin-coated vesicles.
  Nature, 450, 570-574.
PDB codes: 2qy7 2qyw 2v8s
17604721 S.Fath, J.D.Mancias, X.Bi, and J.Goldberg (2007).
Structure and organization of coat proteins in the COPII cage.
  Cell, 129, 1325-1336.
PDB codes: 2pm6 2pm7 2pm9
17615300 S.Pagant, L.Kung, M.Dorrington, M.C.Lee, and E.A.Miller (2007).
Inhibiting endoplasmic reticulum (ER)-associated degradation of misfolded Yor1p does not permit ER export despite the presence of a diacidic sorting signal.
  Mol Biol Cell, 18, 3398-3413.  
17428803 T.Iinuma, A.Shiga, K.Nakamoto, M.B.O'Brien, M.Aridor, N.Arimitsu, M.Tagaya, and K.Tani (2007).
Mammalian Sec16/p250 plays a role in membrane traffic from the endoplasmic reticulum.
  J Biol Chem, 282, 17632-17639.  
17254015 Y.Bogoch, Y.N.Biala, M.Linial, and M.Weinstock (2007).
Anxiety induced by prenatal stress is associated with suppression of hippocampal genes involved in synaptic function.
  J Neurochem, 101, 1018-1030.  
  16967103 A.Slomiany, M.Grabska, and B.L.Slomiany (2006).
Homeostatic restitution of cell membranes. Nuclear membrane lipid biogenesis and transport of protein from cytosol to intranuclear spaces.
  Int J Biol Sci, 2, 216-226.  
16957051 C.A.Bue, C.M.Bentivoglio, and C.Barlowe (2006).
Erv26p directs pro-alkaline phosphatase into endoplasmic reticulum-derived coat protein complex II transport vesicles.
  Mol Biol Cell, 17, 4780-4789.  
16990852 C.Gürkan, S.M.Stagg, P.Lapointe, and W.E.Balch (2006).
The COPII cage: unifying principles of vesicle coat assembly.
  Nat Rev Mol Cell Biol, 7, 727-738.  
16431369 R.Forster, M.Weiss, T.Zimmermann, E.G.Reynaud, F.Verissimo, D.J.Stephens, and R.Pepperkok (2006).
Secretory cargo regulates the turnover of COPII subunits at single ER exit sites.
  Curr Biol, 16, 173-179.  
16912714 R.Jahn, and R.H.Scheller (2006).
SNAREs--engines for membrane fusion.
  Nat Rev Mol Cell Biol, 7, 631-643.  
16495485 S.A.Siddiqi, J.Mahan, S.Siddiqi, F.S.Gorelick, and C.M.Mansbach (2006).
Vesicle-associated membrane protein 7 is expressed in intestinal ER.
  J Cell Sci, 119, 943-950.  
16735505 S.A.Siddiqi, S.Siddiqi, J.Mahan, K.Peggs, F.S.Gorelick, and C.M.Mansbach (2006).
The identification of a novel endoplasmic reticulum to Golgi SNARE complex used by the prechylomicron transport vesicle.
  J Biol Chem, 281, 20974-20982.  
16769213 S.Shikano, B.Coblitz, M.Wu, and M.Li (2006).
14-3-3 proteins: regulation of endoplasmic reticulum localization and surface expression of membrane proteins.
  Trends Cell Biol, 16, 370-375.  
16855025 W.Wen, L.Chen, H.Wu, X.Sun, M.Zhang, and D.K.Banfield (2006).
Identification of the yeast R-SNARE Nyv1p as a novel longin domain-containing protein.
  Mol Biol Cell, 17, 4282-4299.
PDB code: 2fz0
16818719 Y.Guo, and A.D.Linstedt (2006).
COPII-Golgi protein interactions regulate COPII coat assembly and Golgi size.
  J Cell Biol, 174, 53-63.  
16308274 A.Yerrapureddy, T.Korte, S.Hollmann, M.Nordhoff, G.Ahnert-Hilger, A.Herrmann, and M.Veit (2005).
Intracellular interaction between syntaxin and Munc 18-1 revealed by fluorescence resonance energy transfer.
  Mol Membr Biol, 22, 401-410.  
15677328 C.R.Roy (2005).
Bacterial subversion of the host secretory pathway.
  Proc Natl Acad Sci U S A, 102, 1271-1272.  
15930124 E.A.Miller, Y.Liu, C.Barlowe, and R.Schekman (2005).
ER-Golgi transport defects are associated with mutations in the Sed5p-binding domain of the COPII coat subunit, Sec24p.
  Mol Biol Cell, 16, 3719-3726.  
16126486 E.van Anken, and I.Braakman (2005).
Versatility of the endoplasmic reticulum protein folding factory.
  Crit Rev Biochem Mol Biol, 40, 191-228.  
15975775 J.C.Fromme, and R.Schekman (2005).
COPII-coated vesicles: flexible enough for large cargo?
  Curr Opin Cell Biol, 17, 345-352.  
15752134 J.D.Mancias, and J.Goldberg (2005).
Exiting the endoplasmic reticulum.
  Traffic, 6, 278-285.  
15623526 J.Kim, S.Hamamoto, M.Ravazzola, L.Orci, and R.Schekman (2005).
Uncoupled packaging of amyloid precursor protein and presenilin 1 into coat protein complex II vesicles.
  J Biol Chem, 280, 7758-7768.  
15830010 J.M.Hernández, C.Castilla, N.C.Gutiérrez, I.M.Isidro, M.Delgado, J.de las Rivas, E.Fermiñán, J.L.García, E.M.Ocio, M.C.del Cañizo, and J.F.San Miguel (2005).
Mobilisation with G-CSF in healthy donors promotes a high but temporal deregulation of genes.
  Leukemia, 19, 1088-1091.  
15665868 K.Sato, and A.Nakano (2005).
Dissection of COPII subunit-cargo assembly and disassembly kinetics during Sar1p-GTP hydrolysis.
  Nat Struct Mol Biol, 12, 167-174.  
15591128 L.Kapetanovich, C.Baughman, and T.H.Lee (2005).
Nm23H2 facilitates coat protein complex II assembly and endoplasmic reticulum export in mammalian cells.
  Mol Biol Cell, 16, 835-848.  
15899885 L.P.Sun, L.Li, J.L.Goldstein, and M.S.Brown (2005).
Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro.
  J Biol Chem, 280, 26483-26490.  
15975779 M.A.Puthenveedu, and A.D.Linstedt (2005).
Subcompartmentalizing the Golgi apparatus.
  Curr Opin Cell Biol, 17, 369-375.  
16122427 M.C.Lee, L.Orci, S.Hamamoto, E.Futai, M.Ravazzola, and R.Schekman (2005).
Sar1p N-terminal helix initiates membrane curvature and completes the fission of a COPII vesicle.
  Cell, 122, 605-617.  
15580264 P.Watson, R.Forster, K.J.Palmer, R.Pepperkok, and D.J.Stephens (2005).
Coupling of ER exit to microtubules through direct interaction of COPII with dynactin.
  Nat Cell Biol, 7, 48-55.  
15657397 R.Heinrich, and T.A.Rapoport (2005).
Generation of nonidentical compartments in vesicular transport systems.
  J Cell Biol, 168, 271-280.  
15694862 S.P.Salcedo, and D.W.Holden (2005).
Bacterial interactions with the eukaryotic secretory pathway.
  Curr Opin Microbiol, 8, 92-98.  
16155591 S.Shikano, B.Coblitz, H.Sun, and M.Li (2005).
Genetic isolation of transport signals directing cell surface expression.
  Nat Cell Biol, 7, 985-992.  
15623529 W.Shimoi, I.Ezawa, K.Nakamoto, S.Uesaki, G.Gabreski, M.Aridor, A.Yamamoto, M.Nagahama, M.Tagaya, and K.Tani (2005).
p125 is localized in endoplasmic reticulum exit sites and involved in their organization.
  J Biol Chem, 280, 10141-10148.  
15457214 A.M.Lindroth, D.Shultis, Z.Jasencakova, J.Fuchs, L.Johnson, D.Schubert, D.Patnaik, S.Pradhan, J.Goodrich, I.Schubert, T.Jenuwein, S.Khorasanizadeh, and S.E.Jacobsen (2004).
Dual histone H3 methylation marks at lysines 9 and 27 required for interaction with CHROMOMETHYLASE3.
  EMBO J, 23, 4286-4296.  
14764609 A.Soza, A.Norambuena, J.Cancino, E.de la Fuente, P.Henklein, and A.González (2004).
Sorting competition with membrane-permeable peptides in intact epithelial cells revealed discrimination of transmembrane proteins not only at the trans-Golgi network but also at pre-Golgi stages.
  J Biol Chem, 279, 17376-17383.  
14711434 A.Spang (2004).
Vesicle transport: a close collaboration of Rabs and effectors.
  Curr Biol, 14, R33-R34.  
14742712 A.Volchuk, M.Ravazzola, A.Perrelet, W.S.Eng, M.Di Liberto, O.Varlamov, M.Fukasawa, T.Engel, T.H.Söllner, J.E.Rothman, and L.Orci (2004).
Countercurrent distribution of two distinct SNARE complexes mediating transport within the Golgi stack.
  Mol Biol Cell, 15, 1506-1518.  
15550238 B.Antonny (2004).
SNARE filtering by dynamin.
  Cell, 119, 581-582.  
15333032 B.Zhang, and D.Ginsburg (2004).
Familial multiple coagulation factor deficiencies: new biologic insight from rare genetic bleeding disorders.
  J Thromb Haemost, 2, 1564-1572.  
15493870 C.A.Wright, P.Kozik, M.Zacharias, and S.Springer (2004).
Tapasin and other chaperones: models of the MHC class I loading complex.
  Biol Chem, 385, 763-778.  
15017362 C.C.Shoulders, D.J.Stephens, and B.Jones (2004).
The intracellular transport of chylomicrons requires the small GTPase, Sar1b.
  Curr Opin Lipidol, 15, 191-197.  
15611160 C.Z.Chen, M.Calero, C.J.DeRegis, M.Heidtman, C.Barlowe, and R.N.Collins (2004).
Genetic analysis of yeast Yip1p function reveals a requirement for Golgi-localized rab proteins and rab-Guanine nucleotide dissociation inhibitor.
  Genetics, 168, 1827-1841.  
15473838 D.J.Owen, B.M.Collins, and P.R.Evans (2004).
Adaptors for clathrin coats: structure and function.
  Annu Rev Cell Dev Biol, 20, 153-191.  
15457212 E.Futai, S.Hamamoto, L.Orci, and R.Schekman (2004).
GTP/GDP exchange by Sec12p enables COPII vesicle bud formation on synthetic liposomes.
  EMBO J, 23, 4146-4155.  
15475566 F.Paulhe, B.A.Imhof, and B.Wehrle-Haller (2004).
A specific endoplasmic reticulum export signal drives transport of stem cell factor (Kitl) to the cell surface.
  J Biol Chem, 279, 55545-55555.  
15073174 H.Farhan, V.M.Korkhov, V.Paulitschke, M.M.Dorostkar, P.Scholze, O.Kudlacek, M.Freissmuth, and H.H.Sitte (2004).
Two discontinuous segments in the carboxyl terminus are required for membrane targeting of the rat gamma-aminobutyric acid transporter-1 (GAT1).
  J Biol Chem, 279, 28553-28563.  
15117975 J.C.Kagan, M.P.Stein, M.Pypaert, and C.R.Roy (2004).
Legionella subvert the functions of Rab1 and Sec22b to create a replicative organelle.
  J Exp Med, 199, 1201-1211.  
15106609 K.J.Palmer, and D.J.Stephens (2004).
Biogenesis of ER-to-Golgi transport carriers: complex roles of COPII in ER export.
  Trends Cell Biol, 14, 57-61.  
14627716 K.Sato, and A.Nakano (2004).
Reconstitution of coat protein complex II (COPII) vesicle formation from cargo-reconstituted proteoliposomes reveals the potential role of GTP hydrolysis by Sar1p in protein sorting.
  J Biol Chem, 279, 1330-1335.  
15093828 L.C.Bickford, E.Mossessova, and J.Goldberg (2004).
A structural view of the COPII vesicle coat.
  Curr Opin Struct Biol, 14, 147-153.  
15473836 M.C.Lee, E.A.Miller, J.Goldberg, L.Orci, and R.Schekman (2004).
Bi-directional protein transport between the ER and Golgi.
  Annu Rev Cell Dev Biol, 20, 87.  
15123661 M.T.Duvernay, F.Zhou, and G.Wu (2004).
A conserved motif for the transport of G protein-coupled receptors from the endoplasmic reticulum to the cell surface.
  J Biol Chem, 279, 30741-30750.  
15372079 R.Peng, and D.Gallwitz (2004).
Multiple SNARE interactions of an SM protein: Sed5p/Sly1p binding is dispensable for transport.
  EMBO J, 23, 3939-3949.  
15261666 R.Watanabe, and H.Riezman (2004).
Differential ER exit in yeast and mammalian cells.
  Curr Opin Cell Biol, 16, 350-355.  
15261676 T.H.Söllner (2004).
Intracellular and viral membrane fusion: a uniting mechanism.
  Curr Opin Cell Biol, 16, 429-435.  
15479737 X.Wang, J.Matteson, Y.An, B.Moyer, J.S.Yoo, S.Bannykh, I.A.Wilson, J.R.Riordan, and W.E.Balch (2004).
COPII-dependent export of cystic fibrosis transmembrane conductance regulator from the ER uses a di-acidic exit code.
  J Cell Biol, 167, 65-74.  
15123693 Y.Liu, J.J.Flanagan, and C.Barlowe (2004).
Sec22p export from the endoplasmic reticulum is independent of SNARE pairing.
  J Biol Chem, 279, 27225-27232.  
12941266 C.Barlowe (2003).
Molecular recognition of cargo by the COPII complex: a most accommodating coat.
  Cell, 114, 395-397.  
12941277 E.A.Miller, T.H.Beilharz, P.N.Malkus, M.C.Lee, S.Hamamoto, L.Orci, and R.Schekman (2003).
Multiple cargo binding sites on the COPII subunit Sec24p ensure capture of diverse membrane proteins into transport vesicles.
  Cell, 114, 497-509.  
14642281 Y.Mu, T.Otsuka, A.C.Horton, D.B.Scott, and M.D.Ehlers (2003).
Activity-dependent mRNA splicing controls ER export and synaptic delivery of NMDA receptors.
  Neuron, 40, 581-594.  
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB codes are shown on the right.

 

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