Ligand clusters for UniProt code Q16875

Ligand clusters for Q16875: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 from Homo sapiens

		Top 6 (of 7) ligand clusters Cluster 1. 34 ligand types 70 ligands Cluster 2. 8 ligand types 38 ligands Cluster 3. 1 ligand type 1 ligand Cluster 4. 2 ligand types 2 ligands Cluster 5. 1 ligand type 1 ligand Cluster 6. 1 ligand type 1 ligand
Representative protein: 2axnA

Structures

PDB		Schematic diagram
2axnA
6ibzA
6ibxA
6hvhA
6hvjA
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Cluster 1 contains 34 ligand types (of which only 20 are listed. Click for all)

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Ligand		Description
		1. Ligand: ADP × 2 Adenosine-5'-Diphosphate PDB codes: 2dwo(A), 2i1v(B).
		2. Ligand: FDP × 1 2,6-Di-O-Phosphono-Beta-D-Fructofuranose PDB code: 2i1v(B).
		3. Ligand: F6P × 1 6-O-Phosphono-Beta-D-Fructofuranose PDB code: 2dwp(A).
		4. Ligand: DMS × 3 dimethyl sulfoxide Dimethyl sulfoxide PDB codes: 6hvi(A), 6ibx(A), 6ic0(A).
		5. Ligand: EDT × 1 edetic acid {[-(Bis-Carboxymethyl-Amino)-Ethyl]-Carboxymethyl- Amino}-Acetic acid PDB code: 2axn(A).
		6. Ligand: ACP × 1 Phosphomethylphosphonic acid adenylate ester PDB code: 2dwp(A).
		7. Ligand: PEP × 1 Phosphoenolpyruvate PDB code: 2dwo(A).
		8. Ligand: PO4 × 17 Phosphate ion PDB codes: 4d4j(A), 4d4k(A), 4d4l(A), 4d4m(A), 5ajv(B), 5ajw(A), 5ajx(A), 5ajy(A), 5ajz(A), 5ak0(A), 6hvj(A), 6iby(A), 6ibz(A).
		9. Ligand: ADP × 5 Adenosine-5'-Diphosphate PDB codes: 2axn(A), 3qpv(A), 3qpw(A), 4ma4(A), 6etj(A).
		10. Ligand: FLC × 7 Citrate anion PDB codes: 6hvh(A), 6hvi(A), 6hvj(A), 6ibx(A), 6iby(A), 6ibz(A), 6ic0(A).
		11. Ligand: POP × 7 Pyrophosphate 2- PDB codes: 3qpu(A), 6hvh(A), 6hvi(A), 6ibx(A), 6iby(A), 6ic0(A).
		12. Ligand: EDO × 2 1,2-Ethanediol PDB codes: 3qpu(A),
		13. Ligand: FDP × 1 2,6-Di-O-Phosphono-Beta-D-Fructofuranose PDB code: 3qpv(A).
		14. Ligand: PEP × 1 Phosphoenolpyruvate PDB code: 3qpw(A).
		15. Ligand: 87T × 1 N-(4-{[3-(1-Methyl-1h-Pyrazol-4-Yl)-1h-Indol-5- Yl]oxy}phenyl)glycinamide PDB code: 5ajy(A).
		16. Ligand: 8R2 × 1 (2s)-2-Amino-N-[4-[(2-Amino-3-Cyano-1h-Indol-5-Yl) oxy]phenyl]-3-Hydroxy-Propanamide PDB code: 5ajv(B).
		17. Ligand: 8V1 × 1 (2s)-N-[4-[1-Methyl-3-(1-Methylpyrazol-4-Yl)indol-5- Yl]oxyphenyl]pyrrolidine-2-Carboxamide PDB code: 5ak0(A).
		18. Ligand: BKE × 1 7-(4-Methoxyphenyl)-5-Phenyl-3,7-Dihydro-4h-Pyrrolo[2, 3-D]pyrimidin-4-One PDB code: 4d4k(A).
		19. Ligand: BKI × 1 5-(4-Bromophenyl)-7-Phenyl-3,7-Dihydro-4h-Pyrrolo[2,3- D]pyrimidin-4-One PDB code: 4d4j(A).
		20. Ligand: BKS × 1 5-(4-Chlorophenyl)-7-Phenyl-3,7-Dihydro-4h-Pyrrolo[2,3- D]pyrimidin-4-One PDB code: 4d4l(A).
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Cluster 2 contains 8 ligand types

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Ligand		Description
		1. Ligand: F6P × 3 6-O-Phosphono-Beta-D-Fructofuranose PDB codes: 2dwo(A), 2dwp(A), 2i1v(B).
		2. Ligand: PHS × 1 Phosphonic acid PDB code: 2i1v(B).
		3. Ligand: F6P × 20 6-O-Phosphono-Beta-D-Fructofuranose PDB codes: 2axn(A), 3qpv(A), 4d4j(A), 4d4k(A), 4d4l(A), 4d4m(A), 4ma4(A), 5ajw(A), 5ajx(A), 5ajy(A), 5ajz(A), 5ak0(A), 6etj(A), 6hvh(A), 6hvi(A), 6hvj(A), 6ibx(A), 6iby(A), 6ibz(A), 6ic0(A).
		4. Ligand: PHS × 10 Phosphonic acid PDB codes: 3qpv(A), 4d4j(A), 4d4k(A), 4d4l(A), 4d4m(A), 5ajw(A), 5ajx(A), 5ajy(A), 5ajz(A), 5ak0(A).
		5. Ligand: ALF × 1 Tetrafluoroaluminate ion PDB code: 3qpw(A).
		6. Ligand: FDP × 1 2,6-Di-O-Phosphono-Beta-D-Fructofuranose PDB code: 5ajv(B).
		7. Ligand: POP × 1 Pyrophosphate 2- PDB code: 3qpu(A).
		8. Ligand: SRT × 1 S,R meso-Tartaric acid PDB code: 3qpu(A).

Cluster 3 contains 1 ligand type

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Ligand		Description
		1. Ligand: GSH × 1 glutathione Glutathione PDB code: 4ma4(A).

Cluster 4 contains 2 ligand types

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Ligand		Description
		1. Ligand: ACY × 1 acetic acid Acetic acid PDB code: 4ma4(A).
		2. Ligand: MLA × 1 Malonic acid PDB code: 4ma4(A).

Cluster 5 contains 1 ligand type

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Ligand		Description
		1. Ligand: SRT × 1 S,R meso-Tartaric acid PDB code: 3qpu(A).

Cluster 6 contains 1 ligand type

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Ligand		Description
		1. Ligand: DMS × 1 dimethyl sulfoxide Dimethyl sulfoxide PDB code: 6etj(A).