Ligand clusters for UniProt code P81947

Ligand clusters for P81947: Tubulin alpha-1B chain from Bos taurus

		Top 6 (of 12) ligand clusters Cluster 1. 37 ligand types 171 ligands Cluster 2. 2 ligand types 5 ligands Cluster 3. 1 ligand type 3 ligands Cluster 4. 4 ligand types 54 ligands Cluster 5. 2 ligand types 23 ligands Cluster 6. 2 ligand types 13 ligands
Representative protein: 4i4tA

Structures

PDB		Schematic diagram
4i4tA
6fiiA
6hx8A
5oskA
5m54D
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Cluster 1 contains 37 ligand types (of which only 20 are listed. Click for all)

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Ligand		Description
_Mg		1. Metal: _MG × 20 PDB codes: 1jff(A), 3dco(A), 3iz0(A), 4iij(A), 4o4i(A), 4yj3(A), 5hnw(A), 5hnx(A), 5hny(A), 5j2t(A), 5lov(A), 5m50(D), 5m54(D), 5m5c(D), 5nd2(A), 5ogc(A), 5xaf(A), 5xag(A), 5yz3(A), 6gf3(A).
		2. Ligand: GOL × 4 glycerin Glycerol PDB codes: 4o2b(A), 5bmv(A), 5osk(A), 6s9e(A).
		3. Ligand: LOC × 4 colchicine N-[(7s)-1,2,3,10-Tetramethoxy-9-Oxo-6,7-Dihydro-5h- Benzo[d]heptalen-7-Yl]ethanamide PDB codes: 4o2b(A), 5itz(A), 5mio(A), 5nm5(A).
		4. Ligand: GTP × 109 Guanosine-5'-Triphosphate PDB codes: 1jff(A), 3dco(A), 3iz0(A), 4i4t(A), 4i50(A), 4i55(A), 4ihj(A), 4iij(A), 4o2a(A), 4o2b(A), 4o4h(A), 4o4i(A), 4o4j(A), 4o4l(A), 4tuy(A), 4tv8(A), 4tv9(A), 4uxo(A), 4uxp(A), 4uxr(A), 4uxs(A), 4uxt(A), 4uxy(A), 4uy0(A), 4wbn(A), 4yj2(A), 4yj3(A), 5bmv(A), 5eib(C), 5gon(A), 5hnw(A), 5hnx(A), 5hny(A), 5hnz(A), 5itz(A), 5iyz(A), 5j2t(A), 5j2u(A), 5jh7(A), 5jvd(A), 5la6(A), 5lov(A), 5lp6(A), 5lxs(A), 5lxt(A), 5lyj(A), 5m50(D), 5m54(D), 5m5c(D), 5m7e(A), 5m7g(A), 5m8d(A), 5m8g(A), 5mf4(A), 5mio(A), 5nd2(A), 5nd3(A), 5nd4(A), 5nd7(A), 5nfz(A), 5ng1(A), 5njh(A), 5nm5(A), 5nqt(A), 5nqu(A), 5o7a(A), 5oam(A), 5ocu(A), 5ogc(A), 5osk(A), 5ov7(A), 5xaf(A), 5xag(A), 5xlt(A), 5xlz(A), 5yz3(A), 5z4p(A), 6bbn(A), 6f7c(A), 6fii(A), 6fjf(A), 6fjm(A), 6fkj(A), 6fkl(A), 6gf3(A), 6gj4(A), 6gze(A), 6hx8(A), 6i5c(A), 6k9v(A), 6knz(A), 6ojq(A), 6qqn(A), 6qtn(A), 6rev(A), 6rf2(a), 6rf8(A), 6rfd(A), 6s8k(A), 6s9e(A), 6ses(A), 6wvl(A), 6wvm(C), 6wvr(A), 6y6d(A), 6zwb(A), 6zwc(A), 7alr(A), 7jfr(A).
		5. Ligand: 8WB × 2 2-Methoxy-5-(2,3,4-Trimethoxyphenyl)cyclohepta-2,4,6- Trien-1-One PDB codes: 5nfz(A), 5ng1(A).
		6. Ligand: 2RR × 1 3-[(4-{1-[2-(4-Aminophenyl)-2-Oxoethyl]-1h- Benzimidazol-2-Yl}-1,2,5-Oxadiazol-3- Yl) amino]propanenitrile PDB code: 4o2a(A).
		7. Ligand: 4EE × 1 6-(4-Ethoxyphenyl)-3-(2-Methoxyphenyl)-7h-[1,2, 4]triazolo[3,4-B][1,3,4]thiadiazine PDB code: 4yj3(A).
		8. Ligand: 6FS × 1 N-[2-Methoxy-5-({[(E)-2-(2,4,6-Trimethoxyphenyl) ethenyl]sulfonyl}methyl)phenyl]glycine PDB code: 5ov7(A).
		9. Ligand: 6NL × 1 (2e)-3-(3-Hydroxy-4-Methoxyphenyl)-1-(7-Methoxy-2h-1,3- Benzodioxol-5-Yl)-2-Methylprop-2-En-1-One PDB code: 5jvd(A).
		10. Ligand: 6ZR × 1 (3r,4r)-4-(4-Methoxy-3-Oxidanyl-Phenyl)-3-Methyl-1-(3, 4,5-Trimethoxyphenyl)azetidin-2-One PDB code: 5gon(A).
		11. Ligand: 71P × 1 ~{N}-[(7~{r})-1,2,3-Trimethoxy-10-Methylsulfanyl-9- Oxidanylidene-6,7-Dihydro-5~{h}- Benzo[a]heptalen-7- Yl]ethanamide PDB code: 5lp6(A).
		12. Ligand: 7BA × 1 Combretastatin a4 PDB code: 5lyj(A).
		13. Ligand: 84F × 1 (3s,4r)-4-(3-Hydroxy-4-Methoxyphenyl)-3-Methyl-1-(3,4, 5-Trimethoxyphenyl)azetidin-2-One PDB code: 5xaf(A).
		14. Ligand: 89O × 1 (5s,5ar,8ar,9r)-9-(3,5-Dimethoxy-4-Oxidanyl-Phenyl)-5- Oxidanyl-5a,6,8a,9-Tetrahydro-5h- [2]benzofuro[6,5- F][1,3]benzodioxol-8-One PDB code: 5xlt(A).
		15. Ligand: 89U × 1 10-[(4-Methoxy-3-Oxidanyl-Phenyl)methylidene]anthracen- 9-One PDB code: 5xlz(A).
		16. Ligand: 918 × 1 5-(2-Morpholin-4-Yl-6-Pyrrolidin-1-Yl-Pyrimidin-4-Yl)- 4-(Trifluoromethyl)pyridin-2-Amine PDB code: 5m8g(A).
		17. Ligand: 93X × 1 (3~{r},4~{r})-3-(Hydroxymethyl)-4-(4-Methoxy-3- Oxidanyl-Phenyl)-1-(3,4,5- Trimethoxyphenyl)azetidin-2- One PDB code: 5xag(A).
		18. Ligand: 94U × 1 N-[4-(Diethylamino)phenyl]-4h-Pyrrolo[2,3-D][1, 3]thiazole-5-Carboxamide PDB code: 5yz3(A).
		19. Ligand: 97O × 1 6,7,8-Trimethoxy-1-(4-Methoxyphenyl)-4,5-Dihydro-2~{h}- Benzo[e]indazole PDB code: 5z4p(A).
		20. Ligand: A9Q × 1 3-(2,5-Dimethoxybenzyl)-7-Sulfamoyloxy-6-Methoxy-3,4- Dihydroquinazolin-2(1h)-One PDB code: 5osk(A).
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Cluster 2 contains 2 ligand types

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Ligand		Description
		1. Ligand: GDP × 4 Guanosine-5'-Diphosphate PDB codes: 6rev(A), 6rf2(a), 6rf8(A), 6rfd(A).
		2. Ligand: PO4 × 1 Phosphate ion PDB code: 6rf2(a).

Cluster 3 contains 1 ligand type

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Ligand		Description
		1. Ligand: ACP × 3 Phosphomethylphosphonic acid adenylate ester PDB codes: 4i4t(A), 4i55(A), 6fjf(A).

Cluster 4 contains 4 ligand types

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Ligand		Description
		1. Ligand: GOL × 8 glycerin Glycerol PDB codes: 4i4t(A), 4i50(A), 4o2a(A), 4tv9(A), 5jh7(A), 5jvd(A), 5mf4(A).
_Mg		2. Metal: _MG × 1 PDB code: 5lp6(A).
		3. Ligand: MES × 44 2-(N-Morpholino)-Ethanesulfonic acid PDB codes: 4i50(A), 4i55(A), 4ihj(A), 4o2b(A), 4o4i(A), 4tuy(A), 4tv9(A), 4wbn(A), 4yj3(A), 5iyz(A), 5j2t(A), 5jh7(A), 5lp6(A), 5lxs(A), 5lxt(A), 5lyj(A), 5m7e(A), 5m7g(A), 5m8d(A), 5m8g(A), 5mf4(A), 5nfz(A), 5ng1(A), 5ov7(A), 5xlt(A), 5yz3(A), 6f7c(A), 6fii(A), 6fjf(A), 6fjm(A), 6fkj(A), 6fkl(A), 6gf3(A), 6gj4(A), 6gze(A), 6hx8(A), 6i5c(A), 6k9v(A), 6knz(A), 6qqn(A), 6qtn(A), 6s9e(A), 6ses(A), 6y6d(A).
		4. Ligand: IMD × 1 Imidazole PDB code: 4o2a(A).

Cluster 5 contains 2 ligand types

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Ligand		Description
		1. Ligand: GOL × 22 glycerin Glycerol PDB codes: 4i4t(A), 4o2b(A), 4yj2(A), 5bmv(A), 5gon(A), 5jvd(A), 5lyj(A), 5m7e(A), 5m7g(A), 5m8d(A), 5m8g(A), 5mf4(A), 5nfz(A), 5osk(A), 5ov7(A), 5xaf(A), 5xag(A), 5yz3(A), 5z4p(A), 6fkj(A), 6fkl(A), 6s9e(A).
		2. Ligand: IMD × 1 Imidazole PDB code: 5jh7(A).

Cluster 6 contains 2 ligand types

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Ligand		Description
		1. Ligand: GOL × 12 glycerin Glycerol PDB codes: 4i4t(A), 4o2b(A), 4o4j(A), 4tv8(A), 5bmv(A), 5gon(A), 5ov7(A), 5xaf(A), 5xag(A), 5z4p(A), 6s9e(A), 6ses(A).
		2. Ligand: DMS × 1 dimethyl sulfoxide Dimethyl sulfoxide PDB code: 6fjf(A).