Ligand clusters for UniProt code P51449

Ligand clusters for P51449: Nuclear receptor ROR-gamma from Homo sapiens

		Top 6 (of 23) ligand clusters Cluster 1. 137 ligand types 224 ligands Cluster 2. 10 ligand types 11 ligands Cluster 3. 5 ligand types 26 ligands Cluster 4. 3 ligand types 4 ligands Cluster 5. 3 ligand types 5 ligands Cluster 6. 2 ligand types 2 ligands
Representative protein: 5vb3A

Structures

PDB		Schematic diagram
5vb3A
6locA
6lo9A
6lobA
6loaA
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Cluster 1 contains 137 ligand types (of which only 20 are listed. Click for all)

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Ligand		Description
		1. Ligand: GOL × 22 glycerin Glycerol PDB codes: 5c4o(A), 5c4s(A), 5c4t(A), 5c4u(A), 6t4g(A), 6t4i(A), 6t4j(A), 6t4k(A), 6t4t(A), 6t4u(A), 6t4w(A), 6t4x(A), 6t4y(A), 6t50(A), 6tlq(A), 6tlt(A), 6u25(A), 6vqf(A).
		2. Ligand: DMS × 6 dimethyl sulfoxide Dimethyl sulfoxide PDB codes: 4qm0(A), 5aph(A), 5g44(A), 5g45(A), 6r7j(A), 6r7k(A).
		3. Ligand: CLR × 3 cholesterol Cholesterol PDB codes: 6t4g(A), 6t4i(A), 6tlq(A).
		4. Ligand: CHD × 2 cholic acid Cholic acid PDB codes: 6q6o(A),
		5. Ligand: DGX × 1 digoxin Digoxin PDB code: 3b0w(A).
		6. Ligand: YTZ × 1 sulfathiazole 4-Amino-N-(1,3-Thiazol-2-Yl) benzenesulfonamide PDB code: 5g44(A).
		7. Ligand: SO4 × 8 Sulfate ion PDB codes: 4wqp(A), 5c4t(A), 6bn6(A), 6nxh(A), 7jh2(A),
		8. Ligand: LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN-ASP-SER × 7 PDB codes: 3l0j(A), 5apj(A), 5g42(A), 5g45(A), 5g46(A), 5ni8(A), 5nib(A).
		9. Ligand: 4F1 × 6 4-{1-[2-Chloro-6-(Trifluoromethyl)benzoyl]-1h-Indazol- 3-Yl}benzoic acid PDB codes: 4ypq(A), 5c4o(A), 6t4i(A), 6t4k(A), 6t4u(A), 6t4y(A).
		10. Ligand: L3E × 5 4-[(~{E})-[3-[2-Chloranyl-6-(Trifluoromethyl)phenyl]-5- (1~{h}-Pyrrol-3-Yl)-1,2-Oxazol-4- Yl]methylideneamino]benzoic acid PDB codes: 6sal(A), 6t4g(A), 6t4j(A), 6t4t(A), 6t4x(A).
		11. Ligand: LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN × 5 PDB codes: 4xt9(A), 5yp5(A), 5yp6(A), 6e3g(A), 6j3n(A).
		12. Ligand: MJE × 5 4-[1-[2,6-Bis(chloranyl)phenyl]carbonyl-5-Methyl- Thieno[3,2-C]pyrazol-3-Yl]benzoic acid PDB codes: 6t4w(A), 6t50(A), 6tlm(A), 6tlq(A), 6tlt(A).
		13. Ligand: 444 × 4 N-(2,2,2-Trifluoroethyl)-N-{4-[2,2,2-Trifluoro-1- Hydroxy-1- (Trifluoromethyl) ethyl]phenyl}benzenesulfonamide PDB codes: 4nb6(A), 5ejv(A), 5k3l(A), 5ntq(A).
		14. Ligand: HC3 × 4 25-Hydroxycholesterol PDB codes: 3l0l(A), 6t4x(A), 6t4y(A), 6t50(A).
		15. Ligand: THR-LEU-LEU-GLN-LEU-LEU-LEU-GLY × 4 PDB codes: 5nti(A), 5ntn(A), 5nu1(A), 6g05(A).
		16. Ligand: THR-LEU-LEU-GLN-LEU-LEU-LEU-GLY-HIS × 4 PDB codes: 4s14(A), 5ntw(A), 6fzu(A), 6g07(A).
		17. Ligand: EDO × 3 1,2-Ethanediol PDB codes: 5za1(A), 6e3g(A), 6o3z(A).
		18. Ligand: HCD × 3 (3alpha,8alpha)-Cholest-5-Ene-3,20-Diol PDB codes: 6t4t(A), 6t4u(A), 6t4w(A).
		19. Ligand: MHQ × 3 Desmosterol PDB codes: 6t4j(A), 6t4k(A), 6tlt(A).
		20. Ligand: Q6Y × 3 ~{N}-[8-[[(3~{s})-4-Cyclopentylcarbonyl-3-Methyl- Piperazin-1-Yl]methyl]-7-Methyl-Imidazo[1,2- A]pyridin- 6-Yl]-2-Methyl-Pyrimidine-5-Carboxamide PDB codes: 5m96(A),
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Cluster 2 contains 10 ligand types

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 4ymq(A).
		2. Ligand: THR-LEU-LEU-GLN-LEU-LEU-LEU-GLY × 2 PDB codes: 5nti(A), 5ntn(A).
		3. Ligand: DMX × 1 3-[Benzyl(dimethyl)ammonio]propane-1-Sulfonate PDB code: 4nie(A).
		4. Ligand: EDO × 1 1,2-Ethanediol PDB code: 6o3z(A).
		5. Ligand: GLU-PHE-PRO-TYR-LEU-LEU-SER-LEU-LEU-GLY × 1 PDB code: 5iz0(A).
		6. Ligand: HIS-LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN × 1 PDB code: 4nie(A).
		7. Ligand: LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN-ASP-SER × 1 PDB code: 3l0l(A).
		8. Ligand: SER-LEU-LEU-LYS-LYS-LEU-LEU-ASP × 1 PDB code: 4wlb(A).
		9. Ligand: THR-LEU-LEU-GLN-LEU-LEU-LEU-GLY-HIS × 1 PDB code: 5ntw(A).
		10. Ligand: VAL-THR-LEU-LEU-GLN-LEU-LEU-LEU-GLY-HIS × 1 PDB code: 6g07(A).

Cluster 3 contains 5 ligand types

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 6tlq(A).
_Na		2. Metal: _NA × 19 PDB codes: 4ymq(A), 5apj(A), 5g42(A), 5g44(A), 5g45(A), 5g46(A), 5ni5(A), 5ni7(A), 5ni8(A), 5nib(A), 5vb3(A), 5vb5(A), 5vb6(A), 5vb7(A), 5vql(A), 6esn(A), 6r7a(A), 6r7j(A), 6r7k(A).
		3. Ligand: EDO × 4 1,2-Ethanediol PDB codes: 5za1(A), 6o3z(A),
		4. Ligand: TLA × 1 L(+)-Tartaric acid PDB code: 4wlb(A).
_Cl		5. Metal: _CL × 1 PDB code: 5iz0(A).

Cluster 4 contains 3 ligand types

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Ligand		Description
		1. Ligand: DMS × 2 dimethyl sulfoxide Dimethyl sulfoxide PDB codes: 5ni7(A), 5nib(A).
		2. Ligand: 6VD × 1 2-Ethyl-4(1h)-Quinolinone PDB code: 5g46(A).
		3. Ligand: SO4 × 1 Sulfate ion PDB code: 4xt9(A).

Cluster 5 contains 3 ligand types

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 5c4t(A).
		2. Ligand: MPD × 3 (4s)-2-Methyl-2,4-Pentanediol PDB codes: 6br2(A), 6br3(A), 6e3e(A).
		3. Ligand: EDO × 1 1,2-Ethanediol PDB code: 5za1(A).

Cluster 6 contains 2 ligand types

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 5c4u(A).
		2. Ligand: SO4 × 1 Sulfate ion PDB code: 5c4t(A).