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PDBsum entry 6t4j
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Gene regulation
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PDB id
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6t4j
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PDB id:
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| Name: |
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Gene regulation
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Title:
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Ror(gamma)t ligand binding domain in complex with desmosterol and allosteric ligand fm26
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Structure:
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Nuclear receptor ror-gamma. Chain: a. Synonym: nuclear receptor rzr-gamma,nuclear receptor subfamily 1 group f member 3,rar-related orphan receptor c,retinoid-related orphan receptor-gamma. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: rorc, nr1f3, rorg, rzrg. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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1.79Å
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R-factor:
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0.176
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R-free:
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0.197
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Authors:
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R.M.J.M.De Vries,F.A.Meijer,L.Brunsveld
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Key ref:
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f.a.meijer
et al.
(2021).
Cooperativity between the orthosteric and allosteric ligand binding sites of ROR gamma t.
Proc.Natl.Acad.Sci.USA,
118,
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PubMed id:
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Date:
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14-Oct-19
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Release date:
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18-Nov-20
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PROCHECK
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Headers
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References
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P51449
(RORG_HUMAN) -
Nuclear receptor ROR-gamma from Homo sapiens
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Seq:
Struc:
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518 a.a.
241 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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Proc.Natl.Acad.Sci.USA
118:
(2021)
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PubMed id:
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Cooperativity between the orthosteric and allosteric ligand binding sites of ROR gamma t.
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f.a.meijer,
r.g.doveston,
r.m.j.m.de vries,
g.m.vos,
a.a.s.leysen,
m.scheepstra,
c.ottmann,
l.g.milroy,
l.brunsvel.
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ABSTRACT
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Links
