Ligand clusters for UniProt code P49354

Ligand clusters for P49354: Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha from Homo sapiens

		4 ligand clusters Cluster 1. 16 ligand types 29 ligands Cluster 2. 1 ligand type 13 ligands Cluster 3. 2 ligand types 5 ligands Cluster 4. 1 ligand type 1 ligand
Representative protein: 1s63A

Structures

PDB		Schematic diagram
1s63A
2h6gA
2h6hA
2h6fA
1ld7A
		more ...

Cluster 1 contains 16 ligand types

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Ligand		Description
		1. Ligand: ACY × 4 acetic acid Acetic acid PDB codes: 1ld8(A), 2h6f(A),
		2. Ligand: FPP × 7 Farnesyl diphosphate PDB codes: 1jcq(A), 1ld7(A), 1ld8(A), 1mzc(A), 1s63(A), 1sa4(A), 2f0y(A).
		3. Ligand: CYS-VAL-LEU-SER × 3 PDB codes: 2h6f(A), 2h6g(A), 2h6i(A).
		4. Ligand: FAR × 2 Farnesyl PDB codes: 2h6f(A), 2h6h(A).
		5. Ligand: FII × 2 [(3,7,11-Trimethyl-Dodeca-2,6,10-Trienyloxycarbamoyl)- Methyl]-Phosphonic acid PDB codes: 1tn6(A), 2iej(A).
		6. Ligand: 739 × 1 2(s)-{2(s)-[2(r)-Amino-3-Mercapto]propylamino-3(s)- Methyl}pentyloxy-3- Phenylpropionylmethionine sulfone PDB code: 1jcq(A).
		7. Ligand: 778 × 1 4-[(5-{[4-(3-Chlorophenyl)-3-Oxopiperazin-1-Yl]methyl}- 1h-Imidazol-1-Yl)methyl]benzonitrile PDB code: 1s63(A).
		8. Ligand: ACT × 1 Acetate ion PDB code: 2iej(A).
		9. Ligand: BNE × 1 2-[3-(3-Ethyl-1-Methyl-2-Oxo-Azepan-3-Yl)-Phenoxy]-4- [1-Amino-1-(1-Methyl-1h-Imidizol-5-Yl)- Ethyl]- Benzonitrile PDB code: 1mzc(A).
		10. Ligand: ED5 × 1 Tert-Butyl 4-({(2-{(4-Cyanophenyl)[(1-Methyl-1h- Imidazol-5-Yl)methyl]amino}ethyl)[(2- Methylphenyl) sulfonyl]amino}methyl)piperidine-1-Carboxylate PDB code: 3e37(A).
		11. Ligand: GER × 1 Geran-8-Yl geran PDB code: 2h6i(A).
		12. Ligand: JAN × 1 6-[(S)-Amino(4-Chlorophenyl)(1-Methyl-1h-Imidazol-5- Yl)methyl]-4-(3-Chlorophenyl)-1- Methylquinolin-2(1h)- One PDB code: 1sa4(A).
		13. Ligand: PRO-THR-ALA-SER-ALA-CYS-VAL-LEU-SER × 1 PDB code: 2h6h(A).
		14. Ligand: S48 × 1 Methyl n-{(3s)-1-[(1-Methyl-1h-Imidazol-5-Yl)methyl]-6- Phenyl-1,2,3,4-Tetrahydroquinolin-3-Yl}-N- [(1-Methyl- 1h-Imidazol-4-Yl)sulfonyl]glycinate PDB code: 2iej(A).
		15. Ligand: U49 × 1 (20s)-19,20,21,22-Tetrahydro-19-Oxo-5h-18,20-Ethano-12, 14-Etheno-6,10-Metheno-18h- Benz[d]imidazo[4,3-K][1,6, 9,12]oxatri aza-Cyclooctadecosine-9-Carbonitrile PDB code: 1ld8(A).
		16. Ligand: U66 × 1 (20s)-19,20,22,23-Tetrahydro-19-Oxo-5h,21h-18,20- Ethano-12,14-Etheno-6,10- Methenobenz[d]imidazo[4,3- L][1,6,9,13]oxatria zacyclonoadecosine-9-Carbonitrile PDB code: 1ld7(A).

Cluster 2 contains 1 ligand type

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Ligand		Description
		1. Ligand: GLC-FRU × 13 GLC=Alpha-D-Glucopyranose, FRU=Beta-D-Fructofuranose. PDB codes: 1jcq(A), 1ld7(A), 1ld8(A), 1mzc(A), 1s63(A), 1sa4(A), 1tn6(A), 2h6f(A), 2h6g(A), 2h6h(A), 2h6i(A), 2iej(A), 3e37(A).

Cluster 3 contains 2 ligand types

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Ligand		Description
		1. Ligand: ACY × 4 acetic acid Acetic acid PDB codes: 1jcq(A), 1tn6(A), 2h6f(A), 2h6h(A).
		2. Ligand: ACT × 1 Acetate ion PDB code: 2iej(A).

Cluster 4 contains 1 ligand type

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Ligand		Description
		1. Ligand: ACT × 1 Acetate ion PDB code: 2iej(A).