Ligand clusters for UniProt code P43220

Ligand clusters for P43220: Glucagon-like peptide 1 receptor from Homo sapiens

		Top 6 (of 10) ligand clusters Cluster 1. 6 ligand types 9 ligands Cluster 2. 4 ligand types 6 ligands Cluster 3. 1 ligand type 1 ligand Cluster 4. 1 ligand type 2 ligands Cluster 5. 1 ligand type 1 ligand Cluster 6. 1 ligand type 1 ligand
Representative protein: 6ln2A

Structures

PDB		Schematic diagram
6ln2A
6x19R
5nx2A
7lcjR
7lckR
		more ...

Cluster 1 contains 6 ligand types

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Ligand		Description
		1. Ligand: UK4 × 4 2-[(4-{6-[(4-Cyano-2-Fluorophenyl)methoxy]pyridin-2- Yl}piperidin-1-Yl)methyl]-1-{[(2s)-Oxetan-2- Yl]methyl}-1h-Benzimidazole-6-Carboxylic acid PDB codes: 6x1a(R), 7lci(R), 7lcj(R), 7lck(R).
		2. Ligand: 9DK-9DQ-GLY-THR-9DT-THR-SER-ASP-9DW-9DZ × 1 9DK=3-[2-(1~{h}-Imidazol-4-Yl)ethylamino]-2,2-Dimethyl-3- Oxidanylidene-Propanoic acid, 9DQ=(2~{s})-2-Azanyl-3-(1~{h}-1,2,3,4-Tetrazol-5-Yl) propanoic acid, 9DT=(2~{s})-2-Azanyl-3-(2-Fluorophenyl)-2-Methyl-Propanoic acid, 9DW=(2~{s})-2-Azanyl-3-[4-(2-Ethyl-4-Methoxy-Phenyl) phenyl]propanoic acid, 9DZ=(2~{s})-2-Azanyl-5-(3,5-Dimethylphenyl)pentanamide. PDB code: 5nx2(A).
		3. Ligand: FFR × 1 2-[[4-[6-[(4-Cyano-2-Fluoranyl-Phenyl)methoxy]pyridin- 2-Yl]-3,6-Dihydro-2~{h}-Pyridin-1- Yl]methyl]-3- [[(2~{s})-Oxetan-2-Yl]methyl]imidazo[4,5-B]pyridine-5- Carboxylic acid PDB code: 7c2e(R).
		4. Ligand: HEZ × 1 Hexane-1,6-Diol PDB code: 6gb1(A).
		5. Ligand: UK1 × 1 3-{(1s)-1-[5-(2,2-Dimethylmorpholin-4-Yl)-2-{(4s)-2-(4- Fluoro-3,5-Dimethylphenyl)-3-[3-(4-Fluoro- 1-Methyl-1h- Indazol-5-Yl)-2-Oxo-2,3-Dihydro-1h-Imidazol-1-Yl]-4- Methyl-2,4,6,7-Tetrahydro-5h- Pyrazolo[4,3-C]pyridine- 5-Carbonyl}-1h-Indol-1-Yl]butyl}-1,2,4-Oxadiazol- 5(4h)-One PDB code: 6x19(R).
		6. Ligand: V6G × 1 3-[(1s,2s)-1-(5-[(4s)-2,2-Dimethyloxan-4-Yl]-2-{(4s)-2- (4-Fluoro-3,5-Dimethylphenyl)-3-[3-(4- Fluoro-1-Methyl- 1h-Indazol-5-Yl)-2-Oxo-2,3-Dihydro-1h-Imidazol-1-Yl]- 4-Methyl-2,4,6,7- Tetrahydro-5h-Pyrazolo[4,3- C]pyridine-5-Carbonyl}-1h-Indol-1-Yl)-2- Methylcyclopropyl]-1,2,4- Oxadiazol-5(4h)-One PDB code: 6xox(R).

Cluster 2 contains 4 ligand types

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Ligand		Description
		1. Ligand: NAG × 1 n-acetylglucosamine 2-Acetamido-2-Deoxy-Beta-D-Glucopyranose PDB code: 6ln2(A).
		2. Ligand: 10M × 3 Decyl 4-O-Alpha-D-Glucopyranosyl-1-Thio-Beta-D- Glucopyranoside PDB codes: 3c59(A), 3c5t(A), 3iol(A).
		3. Ligand: 32M × 1 3,6,9,12,15,18-Hexaoxahexacosan-1-Ol PDB code: 4zgm(A).
		4. Ligand: NAG-NAG × 1 NAG=2-Acetamido-2-Deoxy-Beta-D-Glucopyranose. PDB code: 5nx2(A).

Cluster 3 contains 1 ligand type

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Ligand		Description
		1. Ligand: 97Y × 1 N-{4-[(R)-(3,3-Dimethylcyclobutyl)({6-[4- (Trifluoromethyl)-1h-Imidazol-1-Yl]pyridin-3- Yl}amino)methyl]benzene-1-Carbonyl}-Beta-Alanine PDB code: 6ln2(A).

Cluster 4 contains 1 ligand type

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Ligand		Description
		1. Ligand: SOG × 2 Octyl 1-Thio-Beta-D-Glucopyranoside PDB codes: 5nx2(A),

Cluster 5 contains 1 ligand type

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Ligand		Description
		1. Ligand: SOG × 1 Octyl 1-Thio-Beta-D-Glucopyranoside PDB code: 5nx2(A).

Cluster 6 contains 1 ligand type

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Ligand		Description
		1. Ligand: NAG × 1 n-acetylglucosamine 2-Acetamido-2-Deoxy-Beta-D-Glucopyranose PDB code: 5nx2(A).