Ligand clusters for UniProt code P30656

Ligand clusters for P30656: Proteasome subunit beta type-5 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)

		6 ligand clusters Cluster 1. 118 ligand types 338 ligands Cluster 2. 2 ligand types 2 ligands Cluster 3. 1 ligand type 1 ligand Cluster 4. 1 ligand type 1 ligand Cluster 5. 2 ligand types 33 ligands Cluster 6. 1 ligand type 232 ligands
Representative protein: 5cz8K

Structures

PDB		Schematic diagram
5cz8K
4no1K
4qv8K
5fgdK
5lajK
		more ...

Cluster 1 contains 118 ligand types (of which only 20 are listed. Click for all)

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Ligand		Description
		1. Ligand: 3BV × 22 carfilzomib N-{(2s)-2-[(Morpholin-4-Ylacetyl)amino]-4- Phenylbutanoyl}-L-Leucyl-N-[(2r,3s,4s)-1,3-Dihydroxy- 2,6-Dimethylheptan-4-Yl]-L-Phenylalaninamide PDB codes: 4qw4(K), 4qw5(K), 4qw6(K), 4qw7(K), 4qwf(K), 4qwg(K), 4qwi(K), 4qwj(K), 4qwk(K), 4qwl(K), 4qwr(K), 4qws(K), 5cz5(K), 5cz9(K), 5d0s(K), 5d0z(K), 5fgg(K), 5fgi(K), 5fhs(K), 5l5e(K), 5l5y(K), 5l65(K).
		2. Ligand: BO2 × 20 bortezomib N-[(1r)-1-(Dihydroxyboryl)-3-Methylbutyl]-N-(Pyrazin-2- Ylcarbonyl)-L-Phenylalaninamide PDB codes: 2f16(K), 3mg0(K), 4qvl(K), 4qvm(K), 4qvn(K), 4qvp(K), 4qvq(K), 4qvv(K), 4qvw(K), 4qvy(K), 4qw0(K), 4qw1(K), 4qw3(K), 4qwu(K), 5bxn(K), 5d0x(K), 5l5f(K), 5l5z(K), 5l66(K), 6hwd(K).
		3. Ligand: GOL × 1 glycerin Glycerol PDB code: 5nif(L).
_Mg		4. Metal: _MG × 1 PDB code: 6h39(K).
		5. Ligand: MES × 112 2-(N-Morpholino)-Ethanesulfonic acid PDB codes: 3mg4(K), 3mg6(K), 3mg7(K), 3mg8(K), 3nzj(K), 3nzw(K), 3oeu(K), 3oev(K), 3sdi(K), 3sdk(K), 3shj(K), 4jsq(K), 4jsu(K), 4jt0(K), 4qlq(K), 4qls(K), 4qlt(K), 4qlu(K), 4qlv(K), 4qw4(K), 4qw5(K), 4qw6(K), 4qw7(K), 4qwf(K), 4qwg(K), 4qwi(K), 4qwj(K), 4qwk(K), 4qwl(K), 4qwr(K), 4qws(K), 4qwx(K), 4qxj(K), 4qz0(K), 4qz1(K), 4qz2(K), 4qz3(K), 4qz4(K), 4qz5(K), 4qz6(K), 4qz7(K), 4qzw(K), 4qzx(K), 4y6z(K), 4y70(K), 4y74(K), 4y75(K), 4y77(K), 4y78(K), 4y7w(K), 4y7x(K), 4y7y(K), 4y80(K), 4y81(K), 4y82(K), 4y84(K), 4y8g(K), 4y8h(K), 4y8i(K), 4y8j(K), 4y8k(K), 4y8l(K), 4y8o(K), 4y8p(K), 4y8q(K), 4y8r(K), 4y8s(K), 4y9z(K), 4ya2(K), 4ya7(K), 4ya9(K), 5ahj(K), 5cgg(K), 5cgh(K), 5cgi(K), 5cz5(K), 5cz9(K), 5d0s(K), 5d0w(K), 5d0z(K), 5fgg(K), 5fgi(K), 5fhs(K), 5jhr(K), 5jhs(K), 5l52(K), 5l54(K), 5l55(K), 5l5p(K), 5l5x(K), 5l5y(K), 5l60(K), 5l61(K), 5l62(K), 5l63(K), 5l64(K), 5l67(K), 5l69(K), 5l6a(K), 5l6b(K), 5ltt(K), 6h39(K), 6htc(K), 6huv(K), 6hv4(K), 6hvw(K), 6hw8(K), 6hw9(K), 6hwa(K), 6hwb(K), 6hwe(K), 6hwf(K).
		6. Ligand: 04C × 18 1,2,4-Trideoxy-4-Methyl-2-{[N-(Morpholin-4-Ylacetyl)-L- Alanyl-O-Methyl-L-Tyrosyl]amino}-1-Phenyl- D-Xylitol PDB codes: 3un4(K), 4qwx(K), 4qxj(K), 4qz0(K), 4qz1(K), 4qz2(K), 4qz3(K), 4qz4(K), 4qz5(K), 4qz6(K), 4qz7(K), 4qzx(K), 5cgi(K), 5l5d(K), 5l5u(K), 5l5x(K), 5l63(K), 5l6b(K).
		7. Ligand: 39V × 6 N-[(3-Methyl-1h-Inden-2-Yl)carbonyl]-D-Alanyl-N-[(2s, 4r)-5-Hydroxy-4-Methyl-3-Oxo-1-Phenylpentan- 2-Yl]-L- Tryptophanamide PDB codes: 4qlt(K), 5l5h(K), 5l5s(K), 5l60(K), 5l67(K), 5ltt(K).
		8. Ligand: 6NV × 5 ~{N}-[(2~{r})-1-[[(2~{s})-3-(4-Methoxyphenyl)-1- [[(2~{s},3~{s},4~{r})-4-Methyl-3,5-Bis(oxidanyl)- 1- Phenyl-Pentan-2-Yl]amino]-1-Oxidanylidene-Propan-2- Yl]amino]-1-Oxidanylidene-Propan-2-Yl]-1- Methyl-5~{h}- Indene-2-Carboxamide PDB codes: 5l55(K), 5l5q(K), 5l5v(K), 5l64(K), 5l6c(K).
		9. Ligand: 79P × 5 (2~{s})-3-(1~{h}-Indol-3-Yl)-~{N}-[(2~{s},3~{s},4~{r})- 4-Methyl-3,5-Bis(oxidanyl)-1-Phenyl-Pentan- 2-Yl]-2- [[(2~{r})-2-(2-Morpholin-4-Ylethanoylamino) propanoyl]amino]propanamide PDB codes: 5l54(K), 5l5o(K), 5l5t(K), 5l62(K), 5l69(K).
		10. Ligand: ACE-LEU-ALA-GAU-POL × 5 ACE=Acetyl group, GAU=(4s)-4-Amino-5-Hydroxypentanoic acid, POL=N-Propanol. PDB codes: 4y7w(K), 4y8s(K), 4y9z(K), 4ya2(K), 4ya7(K).
		11. Ligand: 6N5 × 4 ~{N}-[(2~{s})-1-[[(2~{s})-3-(4-Methoxyphenyl)-1- [[(2~{s},3~{s},4~{r})-4-Methyl-3,5-Bis(oxidanyl)- 1- Phenyl-Pentan-2-Yl]amino]-1-Oxidanylidene-Propan-2- Yl]amino]-1-Oxidanylidene-Propan-2-Yl]-1- Methyl-5~{h}- Indene-2-Carboxamide PDB codes: 5l52(K), 5l5j(K), 5l61(K), 5l68(K).
		12. Ligand: ALD × 3 N-[(Benzyloxy)carbonyl]-L-Leucyl-N-[(2s)-1-Hydroxy-4- Methylpentan-2-Yl]-L-Leucinamide PDB codes: 4nnn(K), 5d0t(K), 5fgh(K).
		13. Ligand: GQH × 3 (2~{s})-~{N}-[(2~{s})-1-[[(2~{s})-1-[4-(Aminomethyl) phenyl]-4-Methylsulfonyl-Butan-2-Yl]amino]-1- Oxidanylidene-Propan-2-Yl]-2-[[(2~{s})-2-Azido-3- Phenyl-Propanoyl]amino]-4-Methyl-Pentanamide PDB codes: 6htd(K), 6hv5(K), 6hvx(K).
		14. Ligand: GQK × 3 (2~{s})-3-(4-Methoxyphenyl)-~{N}-[(2~{s},3~{r})-4- Methyl-3,4-Bis(oxidanyl)-1-Phenyl-Pentan-2-Yl]- 2- [[(2~{s})-2-(2-Morpholin-4-Ylethanoylamino) propanoyl]amino]propanamide PDB codes: 6htc(K), 6hv4(K), 6hwf(K).
		15. Ligand: GQQ × 3 ~{N}-[(2~{s})-1-[[(2~{s})-1-[[(2~{s})-1-[4- (Aminomethyl)phenyl]-4-Methylsulfonyl-Butan-2- Yl]amino]-4-Methyl-1-Oxidanylidene-Pentan-2-Yl]amino]- 4-Methyl-1-Oxidanylidene-Pentan-2- Yl]pyrazine-2- Carboxamide PDB codes: 6htp(K), 6hv7(K), 6hw0(K).
		16. Ligand: GQT × 3 (2~{s})-~{N}-[(2~{s})-1-[[(2~{s})-1-[4-(Aminomethyl) phenyl]-4-Methylsulfonyl-Butan-2-Yl]amino]-3- Oxidanyl- 1-Oxidanylidene-Propan-2-Yl]-2-[[(2~{s})-2-Azido-3- Phenyl-Propanoyl]amino]-4-Methyl- Pentanamide PDB codes: 6htr(K), 6hva(K), 6hw3(K).
		17. Ligand: GRT × 3 (2~{s})-~{N}-[2-[[(2~{s})-1-[4-(Aminomethyl)phenyl]-4- Methylsulfonyl-Butan-2-Yl]amino]-2- Oxidanylidene- Ethyl]-2-[[(2~{s})-2-Azido-3-Phenyl-Propanoyl]amino]- 4-Methyl-Pentanamide PDB codes: 6huc(K), 6hvs(K), 6hw5(K).
		18. Ligand: GRW × 3 (2~{s})-~{N}-[(2~{s},3~{r})-1-[[(2~{s})-1-[4- (Aminomethyl)phenyl]-4-Methylsulfonyl-Butan-2- Yl]amino]-3-Oxidanyl-1-Oxidanylidene-Butan-2-Yl]-2- [[(2~{r})-2-Azido-3-Phenyl-Propanoyl]amino]- 4-Methyl- Pentanamide PDB codes: 6hub(K), 6hvr(K), 6hw4(K).
		19. Ligand: GT5 × 3 ~{N}-[(2~{s})-1-[[(2~{s})-1-[[(2~{s})-1-[4- (Aminomethyl)phenyl]-4-Methylsulfonyl-Butan-2- Yl]amino]-3-Methoxy-1-Oxidanylidene-Propan-2- Yl]amino]-4-Methyl-1-Oxidanylidene-Pentan-2-Yl]-2- Methyl-1,3-Thiazole-5-Carboxamide PDB codes: 6huq(K), 6hvt(K), 6hw6(K).
		20. Ligand: GT8 × 3 (2~{s})-~{N}-[(3~{s},4~{r})-1-Cyclohexyl-5-Methyl-4,5- Bis(oxidanyl)hexan-3-Yl]-3-(4- Methoxyphenyl)-2- [[(2~{s})-2-(2-Morpholin-4-Ylethanoylamino) propanoyl]amino]propanamide PDB codes: 6huv(K), 6hvv(K), 6hw8(K).
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Cluster 2 contains 2 ligand types

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 4x6z(L).
		2. Ligand: EDO × 1 1,2-Ethanediol PDB code: 5nif(L).

Cluster 3 contains 1 ligand type

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 4x6z(L).

Cluster 4 contains 1 ligand type

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 4x6z(L).

Cluster 5 contains 2 ligand types

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Ligand		Description
_Mg		1. Metal: _MG × 32 PDB codes: 4qby(K), 4quy(K), 4qv1(K), 4qv4(K), 4qv5(K), 4qv6(K), 4qv7(K), 4qv8(K), 4qv9(K), 4qvm(K), 4qvn(K), 4qvp(K), 4qvq(K), 4qvv(K), 4qvy(K), 4r02(K), 4r17(K), 4r18(K), 5cz7(K), 5d0x(K), 5fg9(K), 5l5a(K), 5l5w(K), 5l5y(K), 5l5z(K), 5l60(K), 5l61(K), 5l62(K), 5l63(K), 5l64(K), 5lai(K), 5laj(K).
_Cl		2. Metal: _CL × 1 PDB code: 4r00(K).

Cluster 6 contains 1 ligand type

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Ligand		Description
_Mg		1. Metal: _MG × 232 PDB codes: 1g65(K), 1jd2(K), 1ryp(L), 3mg4(K), 3mg6(K), 3mg7(K), 3mg8(K), 3oeu(K), 3oev(K), 3sdi(K), 3sdk(K), 4g4s(L), 4nnn(K), 4nnw(K), 4no6(K), 4no8(K), 4no9(K), 4qby(K), 4qlq(K), 4qlt(K), 4qlu(K), 4qlv(K), 4qux(K), 4quy(K), 4qv0(K), 4qv1(K), 4qv4(K), 4qv5(K), 4qv6(K), 4qv7(K), 4qv8(K), 4qv9(K), 4qvl(K), 4qvm(K), 4qvn(K), 4qvp(K), 4qvq(K), 4qvv(K), 4qvw(K), 4qvy(K), 4qw0(K), 4qw1(K), 4qw4(K), 4qw5(K), 4qw6(K), 4qw7(K), 4qwf(K), 4qwg(K), 4qwi(K), 4qwj(K), 4qwk(K), 4qwl(K), 4qwr(K), 4qws(K), 4qwu(K), 4qwx(K), 4qxj(K), 4qz0(K), 4qz1(K), 4qz2(K), 4qz3(K), 4qz4(K), 4qz5(K), 4qz6(K), 4qz7(K), 4qzw(K), 4qzx(K), 4qzz(K), 4r00(K), 4r02(K), 4r17(K), 4r18(K), 4rur(K), 4y69(K), 4y6a(K), 4y6v(K), 4y6z(K), 4y70(K), 4y74(K), 4y75(K), 4y77(K), 4y78(K), 4y7w(K), 4y7x(K), 4y7y(K), 4y80(K), 4y81(K), 4y82(K), 4y84(K), 4y8g(K), 4y8h(K), 4y8i(K), 4y8j(K), 4y8k(K), 4y8l(K), 4y8m(K), 4y8n(K), 4y8o(K), 4y8p(K), 4y8q(K), 4y8r(K), 4y8s(K), 4y8t(K), 4y8u(K), 4y9y(K), 4y9z(K), 4ya0(K), 4ya1(K), 4ya2(K), 4ya3(K), 4ya4(K), 4ya5(K), 4ya7(K), 4ya9(K), 4z1l(K), 5ahj(K), 5bou(K), 5bxl(K), 5bxn(K), 5cgf(K), 5cgg(K), 5cgh(K), 5cgi(K), 5cz4(K), 5cz5(K), 5cz6(K), 5cz7(K), 5cz8(K), 5cz9(K), 5cza(K), 5d0s(K), 5d0t(K), 5d0v(K), 5d0w(K), 5d0x(K), 5d0z(K), 5dki(K), 5dkj(K), 5fg7(K), 5fg9(K), 5fga(K), 5fgd(K), 5fge(K), 5fgf(K), 5fgg(K), 5fgh(K), 5fgi(K), 5fhs(K), 5jhr(K), 5jhs(K), 5l52(K), 5l54(K), 5l55(K), 5l5a(K), 5l5b(K), 5l5d(K), 5l5e(K), 5l5f(K), 5l5h(K), 5l5i(K), 5l5j(K), 5l5o(K), 5l5p(K), 5l5q(K), 5l5r(K), 5l5s(K), 5l5t(K), 5l5u(K), 5l5v(K), 5l5w(K), 5l5x(K), 5l5y(K), 5l5z(K), 5l60(K), 5l61(K), 5l62(K), 5l63(K), 5l64(K), 5l65(K), 5l66(K), 5l67(K), 5l68(K), 5l69(K), 5l6a(K), 5l6b(K), 5l6c(K), 5lai(K), 5laj(K), 5ltt(K), 5m2b(K), 6g7f(K), 6g8m(K), 6g8n(K), 6gop(K), 6h39(K), 6htb(K), 6htc(K), 6htd(K), 6htp(K), 6htr(K), 6hub(K), 6huc(K), 6huq(K), 6huu(K), 6huv(K), 6hv3(K), 6hv4(K), 6hv5(K), 6hv7(K), 6hva(K), 6hvr(K), 6hvs(K), 6hvt(K), 6hvu(K), 6hvv(K), 6hvw(K), 6hvx(K), 6hvy(K), 6hw0(K), 6hw3(K), 6hw4(K), 6hw5(K), 6hw6(K), 6hw7(K), 6hw8(K), 6hw9(K), 6hwa(K), 6hwb(K), 6hwc(K), 6hwd(K), 6hwe(K), 6hwf(K).