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Ligand clusters for UniProt code P01112

Ligand clusters for P01112: GTPase HRas from Homo sapiens

Top 6 (of 18) ligand clusters


Cluster 1. 34 ligand types 389 ligands		Cluster 2. 9 ligand types 16 ligands		Cluster 3. 7 ligand types 26 ligands		Cluster 4. 5 ligand types 8 ligands		Cluster 5. 5 ligand types 5 ligands		Cluster 6. 7 ligand types 13 ligands

Representative protein: 1aa9A

Structures

PDB		Schematic diagram

1aa9A
4k81B
6ambA
6ntcA
5e95A
		more ...

Cluster 1 contains 34 ligand types (of which only 20 are listed. Click for all)

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Ligand

Description

_Mg

1. Metal: _MG × 147

PDB codes: 121p(A), 1aa9(A), 1agp(A), 1clu(A), 1crq(A), 1ctq(A), 1gnp(A), 1gnq(A), 1gnr(A), 1he8(B), 1iaq(A), 1jah(A), 1k8r(A), 1lf0(A), 1lf5(A), 1lfd(B), 1nvu(Q), 1nvv(Q), 1nvw(Q), 1nvx(Q), 1p2s(A), 1p2t(A), 1p2u(A), 1p2v(A), 1plj(A), 1plk(A), 1q21(A), 1qra(A), 1rvd(A), 1wq1(R), 1xcm(A), 1xd2(A), 1xj0(A), 1zvq(A), 1zw6(A), 221p(A), 2c5l(A), 2cl0(X), 2q21(A), 2quz(A), 2rga(A), 2rgb(A), 2rgc(A), 2rgd(A), 2rge(A), 2rgg(A), 2uzi(R), 2vh5(R), 3ddc(A), 3i3s(R), 3k8y(A), 3k9l(A), 3k9n(A), 3kkm(A), 3kkn(A), 3kud(A), 3l8y(A), 3l8z(A), 3lbh(A), 3lbi(A), 3lbn(A), 3oiu(A), 3oiv(A), 3oiw(A), 3rry(A), 3rrz(A), 3rs0(A), 3rs2(A), 3rs3(A), 3rs4(A), 3rs5(A), 3rs7(A), 3rsl(A), 3rso(A), 3tgp(A), 421p(A), 4dlr(A), 4dls(A), 4dlt(A), 4dlu(A), 4dlv(A), 4dlw(A), 4dlx(A), 4dly(A), 4dlz(A), 4efl(A), 4efm(A), 4efn(A), 4g0n(A), 4g3x(A), 4k81(B), 4l9s(A), 4l9w(A), 4nyi(Q), 4nyj(Q), 4nym(Q), 4q21(A), 4rsg(A), 4xvq(A), 4xvr(A), 521p(A), 5p21(A), 5vbe(A), 5vbz(A), 5wdo(A), 5wdp(A), 5wdq(A), 5wfo(Q), 5wfp(Q), 5wfq(Q), 5wfr(Q), 5wpl(A), 5x9s(A), 621p(A), 6amb(A), 6bvi(A), 6bvj(A), 6bvk(A), 6bvl(A), 6bvm(A), 6cuo(A), 6cup(A), 6cur(A), 6d55(A), 6d56(A), 6d59(A), 6d5e(A), 6d5g(A), 6d5h(A), 6d5j(A), 6d5l(A), 6d5m(Q), 6d5v(Q), 6d5w(Q), 6dzh(A), 6e6c(A), 6e6p(A), 6q21(A), 721p(A), 821p(A).

2. Ligand: GOL × 9

glycerin

Glycerol

PDB codes: 2c5l(A), 3rrz(A), 4k81(B), 6dzh(A), 6e6p(A).

3. Ligand: IPA × 1

isopropyl alcohol

Isopropyl alcohol

PDB code: 1p2u(A).

4. Ligand: TRS × 1

tromethamine

2-Amino-2-Hydroxymethyl-Propane-1,3-Diol

PDB code: 2cl0(X).

_Mn

5. Metal: _MN × 1

PDB code: 1jai(A).

6. Ligand: GNP × 128

Phosphoaminophosphonic acid-Guanylate ester

PDB codes: 1he8(B), 1k8r(A), 1agp(A), 1ctq(A), 1iaq(A), 1lf0(A), 1lfd(B), 1nvv(Q), 1nvw(Q), 1p2s(A), 1p2t(A), 1p2u(A), 1p2v(A), 1xcm(A), 1zw6(A), 221p(A), 2cl0(X), 2lcf(A), 2lwi(A), 2rga(A), 2rgb(A), 2rgc(A), 2rgd(A), 2rge(A), 2rgg(A), 3ddc(A), 3i3s(R), 3k8y(A), 3k9l(A), 3k9n(A), 3kkm(A), 3kkn(A), 3l8y(A), 3l8z(A), 3lbh(A), 3lbi(A), 3lbn(A), 3oiu(A), 3oiv(A), 3oiw(A), 3rry(A), 3rrz(A), 3rs0(A), 3rs2(A), 3rs3(A), 3rs4(A), 3rs5(A), 3rs7(A), 3rsl(A), 3rso(A), 3tgp(A), 421p(A), 4dlr(A), 4dls(A), 4dlt(A), 4dlu(A), 4dlv(A), 4dlw(A), 4dlx(A), 4dly(A), 4dlz(A), 4efl(A), 4efm(A), 4efn(A), 4g0n(A), 4g3x(A), 4l9w(A), 4nyi(Q), 4nyj(Q), 4nym(Q), 4rsg(A), 4xvq(A), 4xvr(A), 5b2z(A), 5b30(A), 5p21(A), 5vbz(A), 5wdo(A), 5wdp(A), 5wdq(A), 5wfo(Q), 5wfp(Q), 5wfq(Q), 5wfr(Q), 5wpl(A), 5x9s(A), 5zc6(A), 621p(A), 6amb(A), 6bvi(A), 6bvj(A), 6bvk(A), 6bvl(A), 6bvm(A), 6cuo(A), 6cup(A), 6cur(A), 6d55(A), 6d56(A), 6d59(A), 6d5e(A), 6d5g(A), 6d5h(A), 6d5j(A), 6d5l(A), 6d5m(Q), 6d5v(Q), 6d5w(Q), 6e6c(A), 6e6p(A), 6ntc(A), 6ntd(A), 6v94(A), 6v9f(A), 6v9j(A), 6v9l(A), 6v9m(A), 6v9n(A), 6v9o(A), 721p(A), 7jhp(A), 821p(A).

7. Ligand: GDP × 30

Guanosine-5'-Diphosphate

PDB codes: 1aa9(A), 1crp(A), 1crq(A), 1crr(A), 1ioz(A), 1lf5(A), 1pll(A), 1q21(A), 1xd2(A), 1xj0(A), 1zvq(A), 2ce2(X), 2cld(X), 2q21(A), 2quz(A), 2x1v(A), 3kud(A), 3lo5(A), 4l9s(A), 4q21(A), 5e95(A), 5vbe(A), 6dzh(A), 6mqt(A), 6zl3(A).

8. Ligand: GTP × 11

Guanosine-5'-Triphosphate

PDB codes: 1nvu(Q), 1nvx(Q), 1plk(A), 1qra(A), 2c5l(A), 2cl7(X), 2clc(X), 2uzi(R), 2vh5(R), 4k81(B), 521p(A).

_Ca

9. Metal: _CA × 11

PDB codes: 1lf0(A), 2rga(A), 2rgb(A), 2rgc(A), 2rgd(A), 2rge(A), 3lo5(E), 3rry(A), 5wdp(A), 5wdq(A), 6dzh(B).

10. Ligand: RSF × 7

(3r,3as,6ar)-Hexahydrofuro[2,3-B]furan-3-Ol

PDB codes: 3rsl(A),

11. Ligand: CAG × 5

Guanosine 5'-Triphosphate p3-[1-(2-Nitrophenyl)ethyl ester]

PDB codes: 1gnq(A), 1gnr(A), 1plj(A), 2cl6(X), 2evw(X).

12. Ligand: GCP × 5

Phosphomethylphosphonic acid guanylate ester

PDB codes: 121p(A), 1jah(A), 1jai(A), 6q21(A), 6zj0(A).

13. Ligand: XY2 × 5

N,N'-Dimethyl-N-(Acetyl)-N'-(7-Nitrobenz-2-Oxa-1,3- Diazol-4-Yl)ethylenediamine

PDB codes: 2ce2(X), 2cl0(X), 2cl7(X), 2clc(X), 2evw(X).

_Cl

14. Metal: _CL × 3

PDB codes: 6d5e(A), 6d5g(A), 6d5h(A).

15. Ligand: DBG × 2

3-Aminobenzophenone-4-Yl- Aminohydroxyphosphinylaminophosphonic acid-Guanylate ester

PDB codes: 1clu(A), 1rvd(A).

16. Ligand: EZZ × 2

(3~{s})-3-[2-[(Dimethylamino)methyl]-1~{h}-Indol-3-Yl]- 5-Oxidanyl-2,3-Dihydroisoindol-1-One

PDB codes: 6zj0(A), 6zl3(A).

17. Ligand: GSP × 2

5'-Guanosine-Diphosphate-Monothiophosphate

PDB codes: 7l0f(E), 7l0g(A).

18. Ligand: PO4 × 2

Phosphate ion

PDB codes: 1nvw(Q), 1xd2(A).

19. Ligand: YEG × 2

Cyclopentanol

PDB codes: 3rs0(A),

20. Ligand: ACT × 1

Acetate ion

PDB code: 5wdq(A).

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Cluster 2 contains 9 ligand types

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Ligand

Description

1. Ligand: DTU × 4

(2r,3s)-1,4-Dimercaptobutane-2,3-Diol

PDB codes: 4dlr(A), 4dlx(A), 4dlz(A), 4g0n(A).

2. Ligand: DTT × 3

2,3-Dihydroxy-1,4-Dithiobutane

PDB codes: 3oiv(A), 4dlv(A), 4dly(A).

3. Ligand: RSF × 2

(3r,3as,6ar)-Hexahydrofuro[2,3-B]furan-3-Ol

PDB codes: 3rsl(A),

_Na

4. Metal: _NA × 2

PDB codes: 5wdo(A), 5wdq(A).

5. Ligand: 92V × 1

1-(4-Methoxyphenyl)-N-(3-Sulfanylpropyl)-5- (Trifluoromethyl)-1h-Pyrazole-4-Carboxamide

PDB code: 5vbe(A).

6. Ligand: DMF × 1

Dimethylformamide

PDB code: 3rs5(A).

7. Ligand: ETF × 1

Trifluoroethanol

PDB code: 3rs2(A).

8. Ligand: HEX × 1

Hexane

PDB code: 3rs3(A).

9. Ligand: HEZ × 1

Hexane-1,6-Diol

PDB code: 3rs4(A).

Cluster 3 contains 7 ligand types

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Ligand

Description

1. Ligand: GOL × 1

glycerin

Glycerol

PDB code: 3rrz(A).

_Ca

2. Metal: _CA × 10

PDB codes: 3k8y(A), 3l8z(A), 3lbh(A), 3lbi(A), 3oiu(A), 3oiw(A), 4dlt(A), 4dlu(A), 4dlw(A), 4g0n(A).

3. Ligand: ACT × 9

Acetate ion

PDB codes: 3k8y(A), 3lbh(A), 3lbi(A), 3oiu(A), 3oiw(A), 4dlt(A), 4dlu(A), 4dlw(A), 4g0n(A).

4. Ligand: ETF × 2

Trifluoroethanol

PDB codes: 1p2s(A), 3rs2(A).

5. Ligand: SO4 × 2

Sulfate ion

PDB codes: 3kkm(A),

6. Ligand: DMF × 1

Dimethylformamide

PDB code: 3rs5(A).

7. Ligand: HEX × 1

Hexane

PDB code: 3rs3(A).

Cluster 4 contains 5 ligand types

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Ligand

Description

1. Ligand: GOL × 1

glycerin

Glycerol

PDB code: 6ntc(A).

2. Ligand: PO4 × 3

Phosphate ion

PDB codes: 1nvu(Q), 1nvv(Q), 1nvw(Q).

_Ca

3. Metal: _CA × 2

PDB codes: 3rsl(A), 4l9w(A).

4. Ligand: DTT × 1

2,3-Dihydroxy-1,4-Dithiobutane

PDB code: 3oiv(A).

5. Ligand: RSF × 1

(3r,3as,6ar)-Hexahydrofuro[2,3-B]furan-3-Ol

PDB code: 3rsl(A).

Cluster 5 contains 5 ligand types

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Ligand

Description

1. Ligand: GOL × 1

glycerin

Glycerol

PDB code: 3rrz(A).

2. Ligand: ACT × 1

Acetate ion

PDB code: 5wdq(A).

3. Ligand: HEZ × 1

Hexane-1,6-Diol

PDB code: 1p2v(A).

4. Ligand: RSF × 1

(3r,3as,6ar)-Hexahydrofuro[2,3-B]furan-3-Ol

PDB code: 3rsl(A).

_Ca

5. Metal: _CA × 1

PDB code: 3l8y(A).

Cluster 6 contains 7 ligand types

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Ligand

Description

_Mg

1. Metal: _MG × 6

PDB codes: 1zw6(A), 2cl7(X), 2clc(X), 4dlr(A), 5wdq(A), 6dzh(B).

2. Ligand: GOL × 1

glycerin

Glycerol

PDB code: 6e6p(A).

3. Ligand: IPA × 1

isopropyl alcohol

Isopropyl alcohol

PDB code: 1p2u(A).

_Zn

4. Metal: _ZN × 1

PDB code: 2uzi(R).

_Ca

5. Metal: _CA × 2

PDB codes: 3l8z(A), 4dly(A).

6. Ligand: DMF × 1

Dimethylformamide

PDB code: 3rs5(A).

_Na

7. Metal: _NA × 1

PDB code: 4l9s(A).