Ligand clusters for UniProt code O94925

Ligand clusters for O94925: Glutaminase kidney isoform, mitochondrial from Homo sapiens

		Top 6 (of 9) ligand clusters Cluster 1. 21 ligand types 38 ligands Cluster 2. 3 ligand types 5 ligands Cluster 3. 1 ligand type 2 ligands Cluster 4. 1 ligand type 1 ligand Cluster 5. 1 ligand type 1 ligand Cluster 6. 1 ligand type 6 ligands
Representative protein: 5uqeA

Structures

PDB		Schematic diagram
5uqeA
6ujmA
6ujgA
6loxA
5fi7A
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Cluster 1 contains 21 ligand types (of which only 20 are listed. Click for all)

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Ligand		Description
		1. Ligand: 04A × 6 N,N'-[Sulfanediylbis(ethane-2,1-Diyl-1,3,4-Thiadiazole- 5,2-Diyl)]bis(2-Phenylacetamide) PDB codes: 3uo9(A), 3voz(A), 3vp1(A), 5uqe(A),
		2. Ligand: SO4 × 4 Sulfate ion PDB codes: 3voy(A), 3voz(A), 3vp0(A), 3vp1(A).
		3. Ligand: 63J × 3 2-(Pyridin-2-Yl)-N-(5-{4-[6-({[3-(Trifluoromethoxy) phenyl]acetyl}amino)pyridazin-3-Yl]butyl}- 1,3,4- Thiadiazol-2-Yl)acetamide PDB codes: 5hl1(A), 5jyo(D).
		4. Ligand: 5XX × 2 2-Phenyl-~{N}-[5-[[(3~{r})-1-[5-(2- Phenylethanoylamino)-1,3,4-Thiadiazol-2-Yl]pyrrolidin- 3- Yl]amino]-1,3,4-Thiadiazol-2-Yl]ethanamide PDB codes: 5fi2(A),
		5. Ligand: 5XY × 2 2-Phenyl-~{N}-[5-[[(3~{s})-1-[5-(2- Phenylethanoylamino)-1,3,4-Thiadiazol-2-Yl]pyrrolidin- 3- Yl]amino]-1,3,4-Thiadiazol-2-Yl]ethanamide PDB codes: 5fi6(A),
		6. Ligand: 69V × 2 2-Phenyl-N-{5-[4-({5-[(Phenylacetyl)amino]-1,3,4- Thiadiazol-2-Yl}oxy)piperidin-1-Yl]-1,3,4- Thiadiazol- 2-Yl}acetamide PDB codes: 5i94(A),
		7. Ligand: B4A × 2 2-Phenyl-N-{5-[4-({5-[(Phenylacetyl)amino]-1,3,4- Thiadiazol-2-Yl}amino)piperidin-1-Yl]-1,3,4- Thiadiazol-2-Yl}acetamide PDB codes: 5wj6(A),
		8. Ligand: QAA × 2 2-Phenyl-N-{6-[4-({6-[(Phenylacetyl)amino]pyridazin-3- Yl}oxy)piperidin-1-Yl]pyridazin-3- Yl}acetamide PDB codes: 6ulj(A),
		9. Ligand: QAJ × 2 2-(Pyridin-3-Yl)-N-(5-{4-[(5-{[(Pyridin-3-Yl) acetyl]amino}-1,3,4-Thiadiazol-2-Yl)amino]piperidin- 1- Yl}-1,3,4-Thiadiazol-2-Yl)acetamide PDB codes: 6ume(A),
		10. Ligand: QAM × 2 N-(5-{[1-(5-Amino-1,3,4-Thiadiazol-2-Yl)piperidin-4- Yl]oxy}-1,3,4-Thiadiazol-2-Yl)-2- Phenylacetamide PDB codes: 6umf(A),
		11. Ligand: 5XZ × 1 2-Phenyl-~{N}-[5-[(3~{s})-3-[[5-(2- Phenylethanoylamino)-1,3,4-Thiadiazol-2- Yl]oxy]pyrrolidin-1- Yl]-1,3,4-Thiadiazol-2- Yl]ethanamide PDB code: 5fi7(A).
		12. Ligand: BP0 × 1 5,5'-(Sulfanediyldiethane-2,1-Diyl)bis(1,3,4- Thiadiazol-2-Amine) PDB code: 3vp2(A).
		13. Ligand: BP8 × 1 5,5'-Pentane-1,5-Diylbis(1,3,4-Thiadiazol-2-Amine) PDB code: 3vp3(A).
		14. Ligand: BP9 × 1 5,5'-Butane-1,4-Diylbis(1,3,4-Thiadiazol-2-Amine) PDB code: 3vp4(A).
		15. Ligand: EN3 × 1 (E)-15,22-Dioxa-4,11-Diaza-5(2,5)-Thiadiazola-10(3,6)- Pyridazina-1,14(1,3)- Dibenzenacyclodocosaphan-18-Ene- 3,12-Dione PDB code: 6lox(A).
		16. Ligand: Q94 × 1 N-{5-[(3r)-3-{[5-(Acetylamino)-1,3,4-Thiadiazol-2- Yl]amino}pyrrolidin-1-Yl]-1,3,4-Thiadiazol-2- Yl}acetamide PDB code: 6ujm(A).
		17. Ligand: Q9A × 1 N-{5-[(3s)-3-{[5-(Acetylamino)-1,3,4-Thiadiazol-2- Yl]amino}pyrrolidin-1-Yl]-1,3,4-Thiadiazol-2- Yl}acetamide PDB code: 6ujg(A).
		18. Ligand: Q9S × 1 5-{4-[(5-Amino-1,3,4-Thiadiazol-2-Yl)oxy]piperidin-1- Yl}-1,3,4-Thiadiazol-2-Amine PDB code: 6uk6(A).
		19. Ligand: Q9V × 1 N-[5-(4-{[5-(Acetylamino)-1,3,4-Thiadiazol-2- Yl]oxy}piperidin-1-Yl)-1,3,4-Thiadiazol-2- Yl]acetamide PDB code: 6ukb(A).
		20. Ligand: QA4 × 1 2-Cyclopropyl-N-{5-[4-({5-[(Cyclopropylacetyl)amino]-1, 3,4-Thiadiazol-2-Yl}oxy)piperidin-1-Yl]- 1,3,4- Thiadiazol-2-Yl}acetamide PDB code: 6ula(A).
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Cluster 2 contains 3 ligand types

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Ligand		Description
		1. Ligand: GLN × 1 l-glutamine PDB code: 3vp0(A).
		2. Ligand: GLU × 3 PDB codes: 3czd(A), 3unw(A), 3vp1(A).
		3. Ligand: ONL × 1 5-Oxo-L-Norleucine PDB code: 4o7d(A).

Cluster 3 contains 1 ligand type

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Ligand		Description
		1. Ligand: GOL × 2 glycerin Glycerol PDB codes: 3czd(A), 3uo9(A).

Cluster 4 contains 1 ligand type

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 3czd(A).

Cluster 5 contains 1 ligand type

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Ligand		Description
		1. Ligand: GOL × 1 glycerin Glycerol PDB code: 3uo9(A).

Cluster 6 contains 1 ligand type

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Ligand		Description
		1. Ligand: SO4 × 6 Sulfate ion PDB codes: 3czd(A), 3voy(A), 3voz(A), 3vp0(A), 3vp1(A), 3vp2(A).