_EC 3.5.99.13 strictosidine synthase. 14 PDB entries  
EC 3.-.-.- Hydrolases. [52,146 PDB entries]
EC 3.5.-.- Acting on carbon-nitrogen bonds, other than peptide bonds. [4,895 PDB entries]
EC 3.5.99.- In other compounds. [95 PDB entries]
EC 3.5.99.13 strictosidine synthase. [14 PDB entries]
2fp8

Reaction: 3alpha(S)-strictosidine + H2O = secologanin + tryptamine.
 


3alpha(S)-strictosidine
 + H2O
 =
secologanin
 +
tryptamine
Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): Str. strictosidine synthetase.
Comments: Catalyzes a Pictet-Spengler reaction between the aldehyde group of secologanin and the amino group of tryptamine. Involved in the biosynthesis of the monoterpenoid indole alkaloids. Formerly Ec 4.3.3.2.
Links:   [IntEnz]   [ExPASy]   [KEGG]  

There are 14 PDB entries in enzyme class E.C.3.5.99.13

  PDB code Protein
2fp8
Structure of strictosidine synthase, the biosynthetic entry to the monoterpenoid indole alkaloid family
Source: Rauvolfia serpentina. Serpentwood. Organism_taxid: 4060. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (302 residues) CATH domain: 2.120.10.30
2fp9
Crystal structure of native strictosidine synthase
Source: Rauvolfia serpentina. Serpentwood. Organism_taxid: 4060. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (305 residues) CATH domain: 2.120.10.30
2fpb
Structure of strictosidine synthase, the biosynthetic entry to the monoterpenoid indole alkaloid family
Source: Rauvolfia serpentina. Serpentwood. Organism_taxid: 4060. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (305 residues) CATH domain: 2.120.10.30
Bound ligand:   Het Group TSS corresponds to enzyme product tryptamine
2fpc
Structure of strictosidine synthase, the biosynthetic entry to the monoterpenoid indole alkaloid family
Source: Rauvolfia serpentina. Serpentwood. Organism_taxid: 4060. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (302 residues) CATH domain: 2.120.10.30
Bound ligand:   Het Group SCG corresponds to enzyme product secologanin
2v91
Structure of strictosidine synthase in complex with strictosidine
Source: Rauvolfia serpentina. Serpentwood. Organism_taxid: 4060. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (302 residues) CATH domain: 2.120.10.30
Bound ligand:   Het Group S55 corresponds to enzyme reactant 3alpha(S)-strictosidine
2vaq
Structure of strictosidine synthase in complex with inhibitor
Source: Rauvolfia serpentina. Serpentwood. Organism_taxid: 4060. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_variant: m15prep4.
Chains: A, B (305 residues) CATH domain: 2.120.10.30
Bound ligand:   Het Group VAW corresponds to enzyme reactant 3alpha(S)-strictosidine
3v1s
Scaffold tailoring by a newly detected pictet-spenglerase ac-tivity of strictosidine synthase (str1): from the common tryp-toline skeleton to the rare piperazino-indole framework
Source: Rauvolfia serpentina. Devilpepper. Organism_taxid: 4060. Gene: str1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (302 residues) CATH domain: 2.120.10.30
Bound ligand:   Het Group 0LH is 71.43% similar to enzyme product tryptamine
4imb
Structure of strictosidine synthase in complex with 2-(1-methyl-1h- indol-3-yl)ethanamine
Source: Rauvolfia serpentina. Devilpepper. Organism_taxid: 4060. Gene: str1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (301 residues) CATH domain: 2.120.10.30
Bound ligand:   Het Group 1ES is 92.31% similar to enzyme product tryptamine
4iyg
Structure of strictosidine synthase in complex with 2-(1h-indol-3-yl)- n-methylethanamine
Source: Rauvolfia serpentina. Devilpepper. Organism_taxid: 4060. Gene: str1. Expressed in: escherichia coli. Expression_system_taxid: 562
Chains: A, B (302 residues) CATH domain: 2.120.10.30
Bound ligand:   Het Group 1HU is 92.31% similar to enzyme product tryptamine
6n5v
Crystal structure of strictosidine in complex with 1h-indole-4- ethanamine
Source: Rauvolfia serpentina. Serpentine wood. Organism_taxid: 4060. Gene: str1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (305 residues)
Bound ligand:   Het Group KDY corresponds to enzyme product tryptamine
6zea
Strictosidine synthase from catharanthus roseus in complex with racemic 1-methyl-2,3,4,9-tetrahydro-1h-beta-carboline
Source: Catharanthus roseus. Madagascar periwinkle. Organism_taxid: 4058. Gene: str1, sss. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008
Chain: A (308 residues)
Bound ligand:   Het Group QGH is 85.71% similar to enzyme product tryptamine
7t5i
Crystal structure of strictosidine synthase in complex with r-ipa(2- (1h-indol-3-yl) propan-1-amine)
Source: Rauvolfia serpentina. Serpentwood. Organism_taxid: 4060. Gene: str1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (305 residues)
Bound ligand:   Het Group XL4 is 92.31% similar to enzyme product tryptamine
7t5j
Crystal structure of strictosidine synthase in complex with s-ipa (2- (1h-indol-3-yl) propan-1-amine)
Source: Rauvolfia serpentina. Serpentwood. Organism_taxid: 4060. Gene: str1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B (305 residues)
Bound ligand:   Het Group XLJ is 92.31% similar to enzyme product tryptamine
8wkl
Rauvolfia serpentina strictosidine synthase (rsstr) in complex with a non-reactive tryptamine substitute crystallized in p1211 space group
Source: Rauvolfia serpentina. Serpentwood. Organism_taxid: 4060. Gene: str1. Expressed in: escherichia coli. Expression_system_taxid: 562.
Chains: A, B, C, D, E, F, G, H (303 residues)
Bound ligand:   Het Group F66 is 92.31% similar to enzyme product tryptamine