The enzyme catalyzes the esterification of an amino acid to the 39-terminal adenosine of a tRNA PMID9736621. The enzyme uses Mg-ATP to perform the catalysis PMID16427818.
CATALYTIC METAL(S)
| Metal/Site Information | |||||
| Residue in MACiE* | Atom in MACiE* | Residue Type in MACiE | Physiological Metal |
Site Type |
Function(s) |
| none | none | magnesium | magnesium | mononuclear | Coordinates substrate Increases electrophilicity Increases acidity Electrostatic stabiliser |
*It refers to the MACiE reference pdb: 1f7u
| Metal/s Properties in Resting State | ||||||
| none | Resting state enzyme (-) | |||||
| Oxidation State | 2 | |||||
| Coordination Geometry | unknownGeometry | |||||
| Coordination Number | unknown | |||||
| Notes | - | |||||
| References |
| -Sekine S, Nureki O, Dubois DY, Bernier S, Chênevert R, Lapointe J, Vassylyev DG, Yokoyama S ATP binding by glutamyl-tRNA synthetase is switched to the productive mode by tRNA binding. EMBO J. 2003 Feb 3;22(3):676-88.(MEDLINE:12554668) |