PDBsum entry 9ltk

Hydrolase

PDB id: 9ltk

Contents

Protein chains

245 a.a.

Ligands

SO4 ×18

GOL ×2

Waters ×538

PDB id:

9ltk

Name:

Hydrolase

Title:

Crystal structur of lpg1618(r215f) from legionella pneumophila

Structure:

Beta-lactamase. Chain: a, b. Engineered: yes. Mutation: yes

Source:

Legionella pneumophila subsp. Pneumophila (strain philadelphia 1 / atcc 33152 / dsm 7513). Organism_taxid: 446. Gene: lpg1618. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.90Å R-factor: 0.171 R-free: 0.187

Authors:

T.Liu,J.Gao,H.Ge

Date:

06-Feb-25 Release date: 25-Jun-25

Protein chains

Q5ZV24  (Q5ZV24_LEGPH) -  Beta-lactamase from Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)

Seq: 280 a.a.

Struc: 245 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.3.5.2.6 - beta-lactamase.
• Pathway: Penicillin Biosynthesis and Metabolism
• Reaction: a beta-lactam + H2O = a substituted beta-amino acid
• Cofactor: Zn(2+)