PDBsum entry 8v9h

Hydrolase

PDB id: 8v9h

Contents

Protein chains

265 a.a.

Ligands

Y33 ×2

EDO ×4

Metals

_CL ×7

IOD ×3

_CA

Waters ×382

PDB id:

8v9h

Name:

Hydrolase

Title:

Ges-5-na-1-157 complex

Structure:

Beta-lactamase. Chain: a, b. Engineered: yes

Source:

Klebsiella pneumoniae. Organism_taxid: 573. Gene: blages-5. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.50Å R-factor: 0.161 R-free: 0.192

Authors:

C.A.Smith,N.K.Stewart,S.B.Vakulenko

Key ref:

N.K.Stewart et al. Restricted rotational flexibility of the c5 alpha-Methyl-Substituted carbapenem na-1-157 leads to inhibition of the ges-5 carbapenemase.. Acs infect dis, . PubMed id: 38511828

Date:

08-Dec-23 Release date: 03-Apr-24

Protein chains

Q09HD0  (BLAG5_KLEPN) -  Beta-lactamase GES-5 from Klebsiella pneumoniae

Seq: 287 a.a.

Struc: 265 a.a.

Enzyme reactions

• Enzyme class: E.C.3.5.2.6 - beta-lactamase.
• Pathway: Penicillin Biosynthesis and Metabolism
• Reaction: a beta-lactam + H2O = a substituted beta-amino acid
• Cofactor: Zn(2+)