PDBsum entry 8slu

Hydrolase

PDB id: 8slu

Contents

Protein chain

282 a.a.

Ligands

SO4 ×2

GOL

Waters ×98

PDB id:

8slu

Name:

Hydrolase

Title:

Crystal structure of human step (ptpn5) at cryogenic temperature (100 k) and high pressure (205 mpa)

Structure:

Tyrosine-protein phosphatase non-receptor type 5. Chain: a. Synonym: neural-specific protein-tyrosine phosphatase,striatum- enriched protein-tyrosine phosphatase,step. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ptpn5. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Resolution:

1.84Å R-factor: 0.197 R-free: 0.237

Authors:

A.Ebrahim,L.Guerrero,B.T.Riley,M.Kim,Q.Huang,A.D.Finke,D.A.Keedy

Key ref:

L.Guerrero et al. Pushed to extremes: distinct effects of high temperat pressure on the structure of an atypical phosphatase. To be published, . PubMed id: 37205580

Date:

24-Apr-23 Release date: 21-Jun-23

Protein chain

P54829  (PTN5_HUMAN) -  Tyrosine-protein phosphatase non-receptor type 5 from Homo sapiens

Seq: 565 a.a.

Struc: 282 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.3.1.3.48 - protein-tyrosine-phosphatase.
• Reaction: O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site