EC 3.1.3.48 - Protein-tyrosine-phosphatase

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IntEnz Enzyme Nomenclature
EC 3.1.3.48

Names

Accepted name:
protein-tyrosine-phosphatase
Other names:
PPT-phosphatase
PTP-phosphatase
PTPase
[phosphotyrosine]protein phosphatase
phosphoprotein phosphatase (phosphotyrosine)
phosphotyrosine histone phosphatase
phosphotyrosine phosphatase
phosphotyrosine protein phosphatase
phosphotyrosylprotein phosphatase
protein phosphotyrosine phosphatase
tyrosine O-phosphate phosphatase
tyrosylprotein phosphatase
Systematic name:
protein-tyrosine-phosphate phosphohydrolase

Reaction

Comments:

Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.1.112 protein-tyrosine kinase.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00323
Structural data: CSA , EC2PDB
Gene Ontology: GO:0004725
CAS Registry Number: 79747-53-8
UniProtKB/Swiss-Prot: (505) [show] [UniProt]

References

  1. Foulkes, J.G., Howard, R.F. and Ziemiecki, A.
    Detection of a novel mammalian protein phosphatase with activity for phosphotyrosine.
    FEBS Lett. 130: 197-200 (1981). [PMID: 6169552]
  2. Gallis, B., Bornstein, P. and Brautigan, D.L.
    Tyrosylprotein kinase and phosphatase activities in membrane vesicles from normal and Rous sarcoma virus-transformed rat cells.
    Proc. Natl. Acad. Sci. USA 78: 6689-6693 (1981). [PMID: 6273884]

[EC 3.1.3.48 created 1984]