PDBsum entry 8hxe

Hydrolase

PDB id: 8hxe

Contents

Protein chains

266 a.a.

Ligands

51I ×2

SCN ×2

Metals

_ZN ×4

Waters ×19

PDB id:

8hxe

Name:

Hydrolase

Title:

Crystal structure of b3 l1 mbl in complex with 2-amino-5-(4- propylbenzyl)thiazole-4-carboxylic acid

Structure:

Metallo-beta-lactamase l1 type 3. Chain: a, b. Synonym: b3 metallo-beta-lactamase,beta-lactamase type iii,metallo- beta-lactamase l1 type iii,penicillinase. Engineered: yes

Source:

Stenotrophomonas maltophilia. Pseudomonas maltophilia, xanthomonas maltophilia. Organism_taxid: 40324. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Resolution:

2.38Å R-factor: 0.222 R-free: 0.299

Authors:

Y.-H.Yan,K.-R.Zhu,G.-B.Li

Key ref:

Y.H.Yan et al. (2023). Discovery of 2-Aminothiazole-4-Carboxylic acids as broad-Spectrum metallo-Beta-Lactamase inhibitors by mimicking carbapenem hydrolysate binding.. J med chem, 66, 13746. PubMed id: 37791640

Date:

04-Jan-23 Release date: 01-Nov-23

Protein chains

P52700  (BLA1_STEMA) -  Metallo-beta-lactamase L1 type 3 from Stenotrophomonas maltophilia

Seq: 290 a.a.

Struc: 266 a.a.

Enzyme reactions

• Enzyme class: E.C.3.5.2.6 - beta-lactamase.
• Pathway: Penicillin Biosynthesis and Metabolism
• Reaction: a beta-lactam + H2O = a substituted beta-amino acid
• Cofactor: Zn(2+)