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UniProt functional annotation for P52700 | ||
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| UniProt code: P52700. |
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| Organism: | |
Stenotrophomonas maltophilia (Pseudomonas maltophilia) (Xanthomonas maltophilia). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Xanthomonadales; Xanthomonadaceae; Stenotrophomonas; Stenotrophomonas maltophilia group. |
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| Function: | |
Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring. {ECO:0000269|PubMed:3931629, ECO:0000269|PubMed:9811546}. |
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| Catalytic activity: | |
Reaction=a beta-lactam + H2O = a substituted beta-amino acid; Xref=Rhea:RHEA:20401, ChEBI:CHEBI:15377, ChEBI:CHEBI:35627, ChEBI:CHEBI:140347; EC=3.5.2.6; Evidence={ECO:0000269|PubMed:3931629}; |
| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:17999929, ECO:0000269|PubMed:9811546}; Note=Binds 2 Zn(2+) ions per subunit. {ECO:0000269|PubMed:17999929, ECO:0000269|PubMed:9811546}; |
| Activity regulation: | |
Inhibited by Hg(2+) or Cu(2+), and by chelating agents such as EDTA and O-phenanthroline. Reduced enzymatic activity in presence of cobalt, nickel, cadmium, and manganese. {ECO:0000269|PubMed:3931629}. |
| Biophysicochemical properties: | |
pH dependence: Unstable below pH 8, unless zinc is present. {ECO:0000269|PubMed:3931629}; |
| Subunit: | |
Homotetramer. {ECO:0000269|PubMed:17999929, ECO:0000269|PubMed:3931629, ECO:0000269|PubMed:9811546}. |
| Subcellular location: | |
Periplasm {ECO:0000305}. |
| Similarity: | |
Belongs to the metallo-beta-lactamase superfamily. Class-B beta-lactamase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.