PDBsum entry 8hv6

Transferase

PDB id: 8hv6

Contents

Protein chain

307 a.a.

Ligands

PE5

N86

DMS

Waters ×149

PDB id:

8hv6

Name:

Transferase

Title:

Crystal structure of egfr_tmx in complex with covalently bound fragment 8

Structure:

Epidermal growth factor receptor. Chain: a. Synonym: proto-oncogenE C-erbb-1,receptor tyrosine-protein kinase erbb-1. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: egfr, erbb, erbb1, her1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Resolution:

2.20Å R-factor: 0.249 R-free: 0.296

Authors:

P.Dokurno

Key ref:

N.Kuki et al. A covalent fragment-Based strategy targeting a novel cysteine to inhibit activity of mutant egfr kinase.. Rsc med chem, . PubMed id: 38107172

Date:

26-Dec-22 Release date: 13-Dec-23

Protein chain

P00533  (EGFR_HUMAN) -  Epidermal growth factor receptor from Homo sapiens

Seq: 1210 a.a.

Struc: 307 a.a.*

* PDB and UniProt seqs differ at 6 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site