PDBsum entry 8cod

Hydrolase

PDB id: 8cod

Contents

Protein chains

429 a.a.

Ligands

NAD ×2

NOS ×2

Metals

_NA ×2

Waters ×322

PDB id:

8cod

Name:

Hydrolase

Title:

Crystal structure of s-adenosyl-l-homocysteine hydrolase from mus musculus in complex with inosine

Structure:

Adenosylhomocysteinase. Chain: a, b. Synonym: adohcyase,cubp,liver copper-binding protein,s-adenosyl-l- homocysteine hydrolase. Engineered: yes

Source:

Mus musculus. House mouse. Organism_taxid: 10090. Gene: ahcy. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Resolution:

2.48Å R-factor: 0.149 R-free: 0.216

Authors:

R.Saleem-Batcha,D.Popadic,L.H.Koeppl,J.N.Andexer

Key ref:

R.Saleem-Batcha et al. Crystal structure of s-Adenosyl-L-Homocysteine hydrol from mus musculus in complex with inosine. To be published, . PubMed id: 38548921

Date:

27-Feb-23 Release date: 06-Mar-24

Protein chains

P50247  (SAHH_MOUSE) -  Adenosylhomocysteinase from Mus musculus

Seq: 432 a.a.

Struc: 429 a.a.

Enzyme reactions

• Enzyme class: E.C.3.13.2.1 - adenosylhomocysteinase.
• Reaction: S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine

S-adenosyl-L-homocysteine + H2O = L-homocysteine (Bound ligand (Het Group name = NOS) matches with 90.00% similarity) + adenosine

Molecule diagrams generated from .mol files obtained from the KEGG ftp site