PDBsum entry 7vm6

Hydrolase

PDB id: 7vm6

Contents

Protein chain

248 a.a.

Ligands

7R8

SO4

PGE

Waters ×140

PDB id:

7vm6

Name:

Hydrolase

Title:

Crystal structure of upa in complex with 6-amidino-2-naphthol

Structure:

Urokinase-type plasminogen activator chain b. Chain: u. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922

Resolution:

1.79Å R-factor: 0.204 R-free: 0.243

Authors:

L.G.Jiang,M.D.Huang

Key ref:

Y.Zhou et al. (2022). Structural study of the upa-Nafamostat complex reveal covalent inhibitory mechanism of nafamostat.. Biophys j, 121, 3940. PubMed id: 36039386

Date:

07-Oct-21 Release date: 12-Oct-22

Protein chain

P00749  (UROK_HUMAN) -  Urokinase-type plasminogen activator from Homo sapiens

Seq: 431 a.a.

Struc: 248 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.3.4.21.73 - u-plasminogen activator.
• Reaction: Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.