_EC 3.4.21.73 u-plasminogen activator.

164 PDB entries

EC 3.-.-.- Hydrolases. [51,952 PDB entries] EC 3.4.-.- Acting on peptide bonds (peptidases). [15,916 PDB entries] EC 3.4.21.- Serine endopeptidases. [4,998 PDB entries] EC 3.4.21.73 u-plasminogen activator. [164 PDB entries]

1c5w

Reaction:		Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
Other name(s):		cellular plasminogen activator. urinary plasminogen activator. urokinase.
Comments:		Formed from the inactive precursor by action of plasmin or plasma kallikrein. Differs in structure from Ec 3.4.21.68, and does not bind to fibrin. Belongs to peptidase family S1. Formerly Ec 3.4.21.31 and Ec 3.4.99.26.
Links:		[IntEnz]   [ExPASy]   [KEGG]

There are 164 PDB entries in enzyme class E.C.3.4.21.73

PDB code		Protein
1c5w		Structural basis for selectivity of a small molecule, s1-binding, sub- micromolar inhibitor of urokinase type plasminogen activator Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Chain: B (248 residues) CATH domains: 2.40.10.10 2.40.10.10
1c5x		Structural basis for selectivity of a small molecule, s1-binding, sub- micromolar inhibitor of urokinase type plasminogen activator Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Chain: B (248 residues) CATH domains: 2.40.10.10 2.40.10.10
1c5y		Structural basis for selectivity of a small molecule, s1-binding, sub- micromolar inhibitor of urokinase type plasminogen activator Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Chain: B (248 residues) CATH domains: 2.40.10.10 2.40.10.10
1c5z		Structural basis for selectivity of a small molecule, s1-binding, sub- micromolar inhibitor of urokinase type plasminogen activator Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Chain: B (245 residues) CATH domains: 2.40.10.10 2.40.10.10
1ejn		Urokinase plasminogen activator b-chain inhibitor complex Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (247 residues) CATH domains: 2.40.10.10 2.40.10.10
1f5k		Urokinase plasminogen activator b-chain-benzamidine complex Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: U (247 residues) CATH domains: 2.40.10.10 2.40.10.10
1f5l		Urokinase plasminogen activator b-chain-amiloride complex Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (245 residues) CATH domains: 2.40.10.10 2.40.10.10
1f92		Urokinase plasminogen activator b chain-uki-1d complex Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (247 residues) CATH domains: 2.40.10.10 2.40.10.10
1fv9		Crystal structure of human microurokinase in complex with 2-amino-5- hydroxy-benzimidazole Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Chain: A (245 residues) CATH domains: 2.40.10.10 2.40.10.10
1gi7		A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Other_details: chem.Biol. 7, 299-312, 2000. Other_details: chem.Biol. 7, 299-312, 2000 Chain: B (245 residues) CATH domains: 2.40.10.10 2.40.10.10
1gi8		A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Other_details: chem.Biol. 7, 299-312, 2000. Other_details: chem.Biol. 7, 299-312, 2000 Chain: B (245 residues) CATH domains: 2.40.10.10 2.40.10.10
1gi9		A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Other_details: chem.Biol. 7, 299-312, 2000. Other_details: chem.Biol. 7, 299-312, 2000 Chain: B (245 residues) CATH domains: 2.40.10.10 2.40.10.10
1gj7		Engineering inhibitors highly selective for the s1 sites of ser190 trypsin-like serine protease drug targets Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: p.Pastoris. Other_details: p.Pastoris Chain: B (246 residues) CATH domains: 2.40.10.10 2.40.10.10
1gj8		Engineering inhibitors highly selective for the s1 sites of ser190 trypsin-like serine protease drug targets Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: p.Pastoris. Other_details: p.Pastoris Chains: A, B (13 residues)
1gj9		Engineering inhibitors highly selective for the s1 sites of ser190 trypsin-like serine protease drug targets Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: p.Pastoris. Other_details: p.Pastoris Chain: B (246 residues) CATH domains: 2.40.10.10 2.40.10.10
1gja		Engineering inhibitors highly selective for the s1 sites of ser190 trypsin-like serine protease drug targets Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: p.Pastoris. Other_details: p.Pastoris Chains: A, B (13 residues)
1gjb		Engineering inhibitors highly selective for the s1 sites of ser190 trypsin-like serine protease drug targets Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: p.Pastoris. Other_details: p.Pastoris Chain: B (246 residues) CATH domains: 2.40.10.10 2.40.10.10
1gjc		Engineering inhibitors highly selective for the s1 sites of ser190 trypsin-like serine protease drug targets Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: p.Pastoris. Other_details: p.Pastoris Chain: B (246 residues) CATH domains: 2.40.10.10 2.40.10.10
1gjd		Engineering inhibitors highly selective for the s1 sites of ser190 trypsin-like serine protease drug targets Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: p.Pastoris. Other_details: p.Pastoris Chains: A, B (13 residues)
1kdu		Sequential 1h nmr assignments and secondary structure of the kringle domain from urokinase Source: Homo sapiens. Human. Organism_taxid: 9606 Chain: A (85 residues) CATH domain: 2.40.20.10
1lmw		Lmw u-pa structure complexed with egrcmk (glu-gly-arg chloromethyl ketone) Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562 Chains: B, D (248 residues) CATH domains: 2.40.10.10 2.40.10.10
1o3p		Elaborate manifold of short hydrogen bond arrays mediating binding of active site-directed serine protease inhibitors Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Chain: B (246 residues) CATH domains: 2.40.10.10 2.40.10.10
1o5a		Dissecting and designing inhibitor selectivity determinants at the s1 site using an artificial ala190 protease (ala190 upa) Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Chain: B (246 residues) CATH domains: 2.40.10.10 2.40.10.10
1o5b		Dissecting and designing inhibitor selectivity determinants at the s1 site using an artificial ala190 protease (ala190 upa) Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Chain: B (245 residues) CATH domains: 2.40.10.10 2.40.10.10
1o5c		Dissecting and designing inhibitor selectivity determinants at the s1 site using an artificial ala190 protease (ala190 upa) Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Chain: B (246 residues) CATH domains: 2.40.10.10 2.40.10.10
1owd		Substituted 2-naphthamidine inhibitors of urokinase Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Chain: A (245 residues) CATH domains: 2.40.10.10 2.40.10.10
1owe		Substituted 2-naphthamidine inhibitors of urokinase Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Chain: A (245 residues) CATH domains: 2.40.10.10 2.40.10.10
1owh		Substituted 2-naphthamidine inhibitors of urokinase Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Chain: A (245 residues) CATH domains: 2.40.10.10 2.40.10.10
1owi		Substituted 2-naphthamidine inhibitors of urokinase Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Chain: A (245 residues) CATH domains: 2.40.10.10 2.40.10.10
1owj		Substituted 2-naphthamidine inhibitors of urokinase Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Chain: A (245 residues) CATH domains: 2.40.10.10 2.40.10.10
1owk		Substituted 2-naphthamidine inhibitors of urokinase Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Chain: A (245 residues) CATH domains: 2.40.10.10 2.40.10.10
1sc8		Urokinase plasminogen activator b-chain-j435 complex Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: homo. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: U (247 residues) CATH domains: 2.40.10.10 2.40.10.10
1sqa		Substituted 2-naphthamidine inhibitors of urokinase Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Chain: A (245 residues) CATH domains: 2.40.10.10 2.40.10.10
1sqo		Substituted 2-naphthamidine inhibitors of urokinase Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Chain: A (245 residues) CATH domains: 2.40.10.10 2.40.10.10
1sqt		Substituted 2-naphthamidine inhibitors of urokinase Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Chain: A (245 residues) CATH domains: 2.40.10.10 2.40.10.10
1u6q		Substituted 2-naphthamadine inhibitors of urokinase Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Chain: A (245 residues) CATH domains: 2.40.10.10 2.40.10.10
1urk		Solution structure of the amino terminal fragment of urokinase-type plasminogen activator Source: Homo sapiens. Human. Organism_taxid: 9606 Chain: A (130 residues) CATH domains: 2.10.25.10 2.40.20.10
1vj9		Urokinase plasminogen activator b-chain-jt464 complex Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: U (247 residues) CATH domains: 2.40.10.10 2.40.10.10
1vja		Urokinase plasminogen activator b-chain-jt463 complex Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: homo. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: U (247 residues) CATH domains: 2.40.10.10 2.40.10.10
1w0z		Urokinase type plasminogen activator Source: Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: U (247 residues) CATH domains: 2.40.10.10 2.40.10.10
1w10		Urokinase type plasminogen activator Source: Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: U (247 residues) CATH domains: 2.40.10.10 2.40.10.10
1w11		Urokinase type plasminogen activator Source: Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: U (247 residues) CATH domains: 2.40.10.10 2.40.10.10
1w12		Urokinase type plasminogen activator Source: Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: U (247 residues) CATH domains: 2.40.10.10 2.40.10.10
1w13		Urokinase type plasminogen activator Source: Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: U (247 residues) CATH domains: 2.40.10.10 2.40.10.10
1w14		Urokinase type plasminogen activator Source: Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: U (247 residues) CATH domains: 2.40.10.10 2.40.10.10
2fd6		Structure of human urokinase plasminogen activator in complex with urokinase receptor and an anti-upar antibody at 1.9 a Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: drosophila. Expression_system_taxid: 7215. Expression_system_cell_line: s2 cells. Mus musculus. House mouse. Organism_taxid: 10090. Chain: A (122 residues) CATH domains: 2.10.25.10 2.40.20.10
2i9a		Crystal structure of the free aminoterminal fragment of urokinase type plasminogen activator (atf) Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227. Chains: A, B, C, D (123 residues) CATH domains: 2.10.25.10 2.40.20.10
2i9b		Crystal structure of atf-urokinase receptor complex Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227. Gene: plaur, mo3, upar. Chains: A, B, C, D (122 residues) CATH domains: 2.10.25.10 2.40.20.10
2nwn		New pharmacophore for serine protease inhibition revealed by crystal structure of human urokinase-type plasminogen activator complexed with a cyclic peptidyl inhibitor, upain-1 Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Synthetic: yes. Other_details: this peptide was chemically synthesized by solid phase synthesis and purified by reverse phase hplc. Chain: A (240 residues) CATH domains: 2.40.10.10 2.40.10.10
2o8t		Crystal structure and binding epitopes of urokinase-type plasminogen activator (c122a/n145q) in complex with inhibitors Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Chain: A (231 residues) CATH domains: 2.40.10.10 2.40.10.10
2o8u		Crystal structure and binding epitopes of urokinase-type plasminogen activator (c122a/n145q/s195a) in complex with inhibitors Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Chain: A (238 residues) CATH domains: 2.40.10.10 2.40.10.10
2o8w		Crystal structure and binding epitopes of urokinase-type plasminogen activator (c122a/n145q/s195a) in complex with inhibitors Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Chain: A (245 residues) CATH domains: 2.40.10.10 2.40.10.10
2r2w		Urokinase plasminogen activator b-chain-gppe complex Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: U (247 residues) CATH domains: 2.40.10.10 2.40.10.10
2vin		Fragment-based discovery of mexiletine derivatives as orally bioavailable inhibitors of urokinase-type plasminogen activator Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (248 residues) CATH domains: 2.40.10.10 2.40.10.10
2vio		Fragment-based discovery of mexiletine derivatives as orally bioavailable inhibitors of urokinase-type plasminogen activator Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (248 residues) CATH domains: 2.40.10.10 2.40.10.10
2vip		Fragment-based discovery of mexiletine derivatives as orally bioavailable inhibitors of urokinase-type plasminogen activator Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (248 residues) CATH domains: 2.40.10.10 2.40.10.10
2viq		Fragment-based discovery of mexiletine derivatives as orally bioavailable inhibitors of urokinase-type plasminogen activator Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (248 residues) CATH domains: 2.40.10.10 2.40.10.10
2viv		Fragment-based discovery of mexiletine derivatives as orally bioavailable inhibitors of urokinase-type plasminogen activator Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (248 residues) CATH domains: 2.40.10.10 2.40.10.10
2viw		Fragment-based discovery of mexiletine derivatives as orally bioavailable inhibitors of urokinase-type plasminogen activator Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (248 residues) CATH domains: 2.40.10.10 2.40.10.10
2vnt		Urokinase-type plasminogen activator inhibitor complex with a 1-(7- sulphoamidoisoquinolinyl)guanidine Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562 Chains: A, B, C, D, E, F (258 residues) CATH domains: 2.40.10.10 2.40.10.10
3bt1		Structure of urokinase receptor, urokinase and vitronectin complex Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227. Gene: vtn. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Chain: A (125 residues) CATH domains: 2.10.25.10 2.40.20.10
3bt2		Structure of urokinase receptor, urokinase and vitronectin complex Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693. Gene: vtn. Mus musculus. House mouse. Chain: A (124 residues) CATH domains: 2.10.25.10 2.40.20.10
3ig6		Low molecular weigth human urokinase type plasminogen activator 2-[6- (3'-aminomethyl-biphenyl-3-yloxy)-4-(3-dimethylamino-pyrrolidin-1- yl)-3,5-difluoro-pyridin-2-yloxy]-4-dimethylamino-benzoic acid complex Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: B, D (245 residues) CATH domains: 2.40.10.10 2.40.10.10
3kgp		Crystal structures of urokinase-type plasminogen activator in complex with 4-(aminomethyl) benzoic acid and 4-(aminomethyl-phenyl)-methanol Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Chain: A (239 residues) CATH domains: 2.40.10.10 2.40.10.10
3khv		Crystal structures of urokinase-type plasminogen activator in complex with 4-(aminomethyl) benzoic acid and 4-(aminomethyl-phenyl)-methanol Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Chain: A (239 residues) CATH domains: 2.40.10.10 2.40.10.10
3kid		The crystal structures of 2-aminobenzothiazole-based inhibitors in complexes with urokinase-type plasminogen activator Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Chain: U (238 residues) CATH domains: 2.40.10.10 2.40.10.10
3laq		Structure-based engineering of species selectivity in the upa-upar interaction Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: plau. Expressed in: drosophila. Expression_system_taxid: 7215. Gene: plaur. Chains: A, B (124 residues) CATH domains: 2.10.25.10 2.40.20.10
3m61		Crystal structure of complex of urokinase and a upain-1 variant(w3a) in ph4.6 condition Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Synthetic: yes. Other_details: synthetic construct Chain: U (247 residues) CATH domains: 2.40.10.10 2.40.10.10
3mhw		The complex crystal structure of urokianse and 2-aminobenzothiazole Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: human. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Chain: U (246 residues) CATH domains: 2.40.10.10 2.40.10.10
3mwi		The complex crystal structure of urokianse and 5-nitro-1h-indole-2- amidine Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: human. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Chain: U (246 residues) CATH domains: 2.40.10.10 2.40.10.10
3ox7		The crystal structure of upa complex with peptide inhibitor mh027 at ph4.6 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Synthetic: yes. Other_details: this peptide was chemically synthesized by solid phase synthesis and purified by reverse phase hplc Chain: U (246 residues) CATH domains: 2.40.10.10 2.40.10.10
3oy5		The crystal structure of upa complex with peptide inhibitor mh027 at ph7.4 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Synthetic: yes. Other_details: this peptide was chemically synthesized by solid phase synthesis and purified by reverse phase hplc Chain: U (247 residues) CATH domains: 2.40.10.10 2.40.10.10
3oy6		The crystal structure of upa complex with peptide inhibitor mh036 at ph4.6 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Synthetic: yes. Other_details: this peptide was chemically synthesized by solid phase synthesis and purified by reverse phase hplc Chain: U (247 residues) CATH domains: 2.40.10.10 2.40.10.10
3pb1		Crystal structure of a michaelis complex between plasminogen activator inhibitor-1 and urokinase-type plasminogen activator Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: serpine1, pai1, planh1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: plau, rp11-417o11.1-002. Expressed in: pichia pastoris. Expression_system_taxid: 4922 Chain: E (247 residues) CATH domains: 2.40.10.10 2.40.10.10
3qn7		Potent and selective bicyclic peptide inhibitor (uk18) of human urokinase-type plasminogen activator(upa) Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: human embryonic kidney cells (hek-293). Expression_system_cell: mammalian cells. Synthetic: yes. Chain: A (245 residues) CATH domains: 2.40.10.10 2.40.10.10
3u73		Crystal structure of stabilized human upar mutant in complex with atf Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mo3, plaur, upar. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227. Expression_system_cell_line: s2 cells. Gene: plau. Chain: A (123 residues) CATH domains: 2.10.25.10 2.40.20.10
4dva		The crystal structure of human urokinase-type plasminogen activator catalytic domain Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Chain: U (246 residues) CATH domains: 2.40.10.10 2.40.10.10
4dw2		The crystal structure of upa in complex with the fab fragment of mab- 112 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Mus musculus. Organism_taxid: 10090. Organism_taxid: 10090 Chain: U (221 residues) CATH domains: 2.40.10.10 2.40.10.10
4fu7		Crystal structure of the urokinase Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (246 residues) CATH domains: 2.40.10.10 2.40.10.10
4fu8		Crystal structure of the urokinase Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (246 residues) CATH domains: 2.40.10.10 2.40.10.10
4fu9		Crystal structure of the urokinase Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (246 residues) CATH domains: 2.40.10.10 2.40.10.10
4fub		Crystal structure of the urokinase Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (246 residues) CATH domains: 2.40.10.10 2.40.10.10
4fuc		Crystal structure of the urokinase Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (246 residues) CATH domains: 2.40.10.10 2.40.10.10
4fud		Crystal structure of the urokinase Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (246 residues) CATH domains: 2.40.10.10 2.40.10.10
4fue		Crystal structure of the urokinase Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (246 residues) CATH domains: 2.40.10.10 2.40.10.10
4fuf		Crystal structure of the urokinase Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (246 residues) CATH domains: 2.40.10.10 2.40.10.10
4fug		Crystal structure of the urokinase Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (246 residues) CATH domains: 2.40.10.10 2.40.10.10
4fuh		Crystal structure of the urokinase Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (246 residues) CATH domains: 2.40.10.10 2.40.10.10
4fui		Crystal structure of the urokinase Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (246 residues) CATH domains: 2.40.10.10 2.40.10.10
4fuj		Crystal structure of the urokinase Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: escherichia coli. Expression_system_taxid: 562 Chain: A (246 residues) CATH domains: 2.40.10.10 2.40.10.10
4gly		Human urokinase-type plasminogen activator upa in complex with the two-disulfide bridge peptide uk504 Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: 9606. Gene: plau. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek-293. Synthetic: yes. Chain: A (245 residues) CATH domains: 2.40.10.10 2.40.10.10
4h42		Synthesis of a weak basic upa inhibitor and crystal structure of complex with upa Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Chain: U (248 residues) CATH domains: 2.40.10.10 2.40.10.10
4jk5		Human urokinase-type plasminogen activator (upa) in complex with a bicyclic peptide inhibitor (uk18-d-ser) Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: 9606. Gene: plau. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek-293. Synthetic: yes. Chain: A (245 residues) CATH domains: 2.40.10.10 2.40.10.10
4jk6		Human urokinase-type plasminogen activator (upa) in complex with a bicyclic peptide inhibitor (uk18-d-aba) Source: Homo sapiens. Human. Organism_taxid: 9606. Strain: 9606. Gene: plau. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek-293. Synthetic: yes. Chain: A (245 residues) CATH domains: 2.40.10.10 2.40.10.10
4k24		Structure of anti-upar fab atn-658 in complex with upar Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: drosophila melanogaster. Expression_system_taxid: 7227. Gene: vtn. Expressed in: escherichia coli. Expression_system_taxid: 562. Chain: A (125 residues)
4mnv		Crystal structure of bicyclic peptide uk729 bound as an acyl-enzyme intermediate to urokinase-type plasminogen activator (upa) Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek 293. Synthetic: yes. Other_details: modified with 1,3,5-tris(bromomethyl)benzene (tbmb) Chain: A (245 residues) CATH domains: 2.40.10.10 2.40.10.10
4mnw		Crystal structure of urokinase-type plasminogen activator (upa) complexed with bicyclic peptide uk749 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek 293. Synthetic: yes. Other_details: modified with 1,3,5-tris(bromomethyl)benzene (tbmb) Chain: A (245 residues) CATH domains: 2.40.10.10 2.40.10.10
4mnx		Crystal structure of urokinase-type plasminogen activator (upa) complexed with bicyclic peptide uk811 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek 293. Synthetic: yes. Other_details: modified with 1,3,5-triacryloyl-1,3,5-triazinane Chain: A (245 residues) CATH domains: 2.40.10.10 2.40.10.10
4mny		Crystal structure of urokinase-type plasminogen activator (upa) complexed with bicyclic peptide uk903 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek 293. Synthetic: yes. Other_details: modified with n,n',n''-(benzene-1,3,5-triyl)tris(2- Chains: A, B (245 residues) CATH domains: 2.40.10.10 2.40.10.10
4os1		Crystal structure of urokinase-type plasminogen activator (upa) complexed with bicyclic peptide uk601 (bicyclic 1) Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293. Synthetic: yes Chain: A (245 residues) CATH domains: 2.40.10.10 2.40.10.10
4os2		Crystal structure of urokinase-type plasminogen activator (upa) complexed with bicyclic peptide uk602 (bicyclic 1) Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293. Synthetic: yes Chain: A (245 residues) CATH domains: 2.40.10.10 2.40.10.10
4os4		Crystal structure of urokinase-type plasminogen activator (upa) complexed with bicyclic peptide uk603 (bicyclic 1) Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293. Synthetic: yes Chain: A (245 residues) CATH domains: 2.40.10.10 2.40.10.10
4os5		Crystal structure of urokinase-type plasminogen activator (upa) complexed with bicyclic peptide uk603 (bicyclic 2) Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293. Synthetic: yes Chain: A (245 residues) CATH domains: 2.40.10.10 2.40.10.10
4os6		Crystal structure of urokinase-type plasminogen activator (upa) complexed with bicyclic peptide uk604 (bicyclic 2) Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293. Synthetic: yes Chain: A (245 residues) CATH domains: 2.40.10.10 2.40.10.10
4os7		Crystal structure of urokinase-type plasminogen activator (upa) complexed with bicyclic peptide uk607 (bicyclic) Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: hek293. Synthetic: yes Chain: A (245 residues) CATH domains: 2.40.10.10 2.40.10.10
4x0w		The crystal structure of mupain-1-17 in complex with murinised human upa Source: Synthetic: yes. Synthetic construct. Organism_taxid: 32630. Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922 Chain: U (247 residues) CATH domains: 2.40.10.10 2.40.10.10
4x1n		The crystal structure of mupain-1-16 in complex with murinised human upa at ph7.4 Source: Synthetic: yes. Synthetic construct. Organism_taxid: 32630. Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922 Chain: U (247 residues) CATH domains: 2.40.10.10 2.40.10.10
4x1p		The crystal structure of mupain-1-17 in complex with murinised human upa at ph4.6 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: pichia pastoris. Expression_system_taxid: 4922. Synthetic: yes. Synthetic construct. Organism_taxid: 32630 Chain: U (247 residues) CATH domains: 2.40.10.10 2.40.10.10
4x1q		The crystal structure of mupain-1 in complex with murinised human upa at ph7.4 Source: Synthetic: yes. Synthetic construct. Organism_taxid: 32630. Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922 Chain: U (247 residues) CATH domains: 2.40.10.10 2.40.10.10
4x1r		The crystal structure of mupain-1-12 in complex with murinised human upa at ph7.4 Source: Synthetic: yes. Synthetic construct. Organism_taxid: 32630. Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922 Chain: U (247 residues) CATH domains: 2.40.10.10 2.40.10.10
4x1s		The crystal structure of mupain-1-16-d9a in complex with murinised human upa at ph7.4 Source: Synthetic: yes. Synthetic construct. Organism_taxid: 32630. Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922 Chain: U (246 residues) CATH domains: 2.40.10.10 2.40.10.10
4xsk		Structure of paitrap, an upa mutant Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris gs115. Expression_system_taxid: 644223 Chain: U (246 residues) CATH domains: 2.40.10.10 2.40.10.10
4zhl		The crystal structure of mupain-1-ig in complex with murinised human upa at ph7.4 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922. Synthetic: yes. Synthetic construct. Organism_taxid: 32630 Chain: U (247 residues) CATH domains: 2.40.10.10 2.40.10.10
4zhm		The crystal structure of mupain-1--16-ig in complex with murinised human upa at ph7.4 Source: Synthetic: yes. Synthetic construct. Organism_taxid: 32630. Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922 Chain: U (247 residues) CATH domains: 2.40.10.10 2.40.10.10
4zkn		The crystal structure of upain-1-w3a in complex with upa at ph5.5 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922. Synthetic: yes. Synthetic construct. Organism_taxid: 32630 Chain: U (245 residues) CATH domains: 2.40.10.10 2.40.10.10
4zko		The crystal structure of upain-1-w3a in complex with upa at ph7.4 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922. Synthetic: yes. Synthetic construct. Organism_taxid: 32630. Chain: U (247 residues) CATH domains: 2.40.10.10 2.40.10.10
4zkr		The crystal structure of upain-1-w3a in complex with upa at ph9.0 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922. Synthetic: yes. Synthetic construct. Organism_taxid: 32630 Chain: U (246 residues) CATH domains: 2.40.10.10 2.40.10.10
4zks		The crystal structure of upain-1-w3a in complex with inactive upa (upa-s195a) at ph7.4 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922. Synthetic: yes. Synthetic construct. Organism_taxid: 32630 Chain: U (246 residues) CATH domains: 2.40.10.10 2.40.10.10
5hgg		Crystal structure of upa in complex with a camelid-derived antibody fragment Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris cbs 7435. Expression_system_taxid: 981350. Vicugna pacos. Organism_taxid: 30538. Expressed in: escherichia coli. Chains: A, B (246 residues) CATH domains: 2.40.10.10 2.40.10.10
5lhn		The catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric inhibitory nanobody nb7 Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: plau. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Vicugna pacos. Alpaca. Organism_taxid: 30538. Chain: A (238 residues)
5lhp		The p-aminobenzamidine active site inhibited catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric inhibitory nanobody nb7 Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: plau. Expressed in: escherichia coli. Expression_system_taxid: 562. Vicugna pacos. Organism_taxid: 30538. Expression_system_taxid: 562 Chain: A (247 residues)
5lhq		The egr-cmk active site inhibited catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric inhibitory nanobody nb7 Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: plau. Expressed in: escherichia coli. Expression_system_taxid: 562. Vicugna pacos. Alpaca. Organism_taxid: 30538. Chain: A (247 residues)
5lhr		The catalytic domain of murine urokinase-type plasminogen activator in complex with the active site binding inhibitory nanobody nb22 Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: plau. Expressed in: escherichia coli. Expression_system_taxid: 562. Vicugna pacos. Organism_taxid: 30538. Expression_system_taxid: 562 Chain: A (245 residues)
5lhs		The ligand free catalytic domain of murine urokinase-type plasminogen activator Source: Mus musculus. House mouse. Organism_taxid: 10090. Gene: plau. Expressed in: escherichia coli. Expression_system_taxid: 562. Chains: B, A, C, D (224 residues)
5wxf		Crystal structure of upa in complex with upain-2-2 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922. Synthetic: yes. Phage display vector ptdisp. Organism_taxid: 279974 Chain: U (246 residues)
5wxo		Crystal structure of upa in complex with upain-2-2-w3a Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922. Synthetic: yes. Phage display vector ptdisp. Organism_taxid: 279974 Chain: U (246 residues)
5wxp		Crystal structure of upa in complex with upain-2-3-w3a Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922. Synthetic: yes. Phage display vector ptdisp. Organism_taxid: 279974 Chain: U (248 residues)
5wxq		Crystal structure of upa in complex with upain-2-4 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922. Synthetic: yes. Phage display vector ptdisp. Organism_taxid: 279974 Chain: U (245 residues)
5wxr		Crystal structure of upa in complex with upain-2-4-w3a Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922. Synthetic: yes. Phage display vector ptdisp. Organism_taxid: 279974 Chain: U (245 residues)
5wxs		Crystal structure of upa in complex with s2444 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922 Chain: U (246 residues)
5wxt		Crystal structure of upa-s195a in complex with s2444 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922 Chain: U (245 residues)
5xg4		Crystal structure of upa in complex with quercetin Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922 Chain: U (246 residues)
5yc6		The crystal structure of upa in complex with 4-bromobenzylamirne at ph4.6 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922 Chain: U (246 residues)
5yc7		The crystal structure of upa in complex with 4-bromobenzylamirne at ph7.4 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922 Chain: U (246 residues)
5z1c		The crystal structure of upa in complex with 4-iodobenzylamine at ph7.4 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922 Chain: U (245 residues)
5za7		Upa-hma Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922 Chain: U (246 residues)
5za8		Upa-bb2-27f Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922 Chain: U (245 residues)
5za9		Upa-bb2-50f Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922 Chain: U (245 residues)
5zae		Upa-6f-hma Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922 Chain: U (246 residues)
5zaf		Upa-bb2-28f Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922 Chain: U (245 residues)
5zag		Upa-bb2-94f Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922 Chain: U (245 residues)
5zah		Upa-bb2-30f Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922 Chain: U (245 residues)
5zaj		Upa-31f Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922 Chain: U (245 residues)
5zc5		Upa-nu-09f Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922 Chain: U (245 residues)
6a8g		The crystal structure of mupain-1-ig in complex with mupa-spd at ph8.5 Source: Synthetic: yes. Phage display vector ptdisp. Organism_taxid: 279974. Mus musculus. Mouse. Organism_taxid: 10090. Gene: plau. Expressed in: escherichia coli 'bl21-gold(de3)plyss ag'. Expression_system_taxid: 866768 Chains: A, B (245 residues)
6a8n		The crystal structure of mupain-1-ig-2 in complex with mupa-spd at ph8.5 Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: plau. Expressed in: escherichia coli 'bl21-gold(de3)plyss ag'. Expression_system_taxid: 866768. Synthetic: yes. Phage display vector ptdisp. Organism_taxid: 279974 Chains: A, B (245 residues)
6ag2		Upa-hma Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris gs115. Expression_system_taxid: 644223 Chain: U (245 residues)
6ag3		Crystal structure of upa in complex with 3,5-bis(azanyl)-n- carbamimidoyl-6-(2,4-dimethoxypyrimidin-5-yl)pyrazine-2-carboxamide Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922 Chain: U (245 residues)
6ag7		The crystal structure of upa in complex with hma-55f Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922 Chain: U (245 residues)
6ag9		Crystal structure of upa in complex with 3,5-bis(azanyl)-6-(1- benzofuran-2-yl)-n-carbamimidoyl-pyrazine-2- carboxamide Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922 Chain: U (245 residues)
6jyp		Crystal structure of upa_h99y in complex with 3-azanyl-5-(azepan-1- yl)-n-[bis(azanyl)methylidene]-6-chloranyl-pyrazine-2-carboxamide Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922 Chain: U (246 residues)
6jyq		Crystal structure of upa_h99y in complex with 3-azanyl-5-(azepan-1- yl)-n-carbamimidoyl-6-(furan-2-yl)pyrazine-2-carboxamide Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922 Chain: U (246 residues)
6l04		Crystal structure of upa_h99y in complex with 31f Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922 Chain: U (245 residues)
6l05		Crystal structure of upa_h99y in complex with 50f Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922 Chain: U (245 residues)
6nmb		Tranexamic acid is an active site inhibitor of urokinase plasminogen activator Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: expi293. Expression_system_atcc_number: crl-1573. Expression_system_tissue: embryonic kidney. Chains: A, B, C, D (251 residues)
6xvd		Crystal structure of complex of urokinase and a upain-1 variant(w3f) in ph7.4 condition Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922. Synthetic: yes. Synthetic construct. Organism_taxid: 32630 Chain: U (248 residues)
7dzd		Crystal structure of upa in complex with cleaved camostat Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922 Chain: U (245 residues)
7vm4		Crystal structure of upa in complex with nafamostat Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922 Chain: U (245 residues)
7vm5		Crystal structure of upa in complex with 4-guanidinobenzoic acid Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922 Chain: U (246 residues)
7vm6		Crystal structure of upa in complex with 6-amidino-2-naphthol Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922 Chain: U (248 residues)
7vm7		Crystal structure of inactive upa in complex with nafamostat Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: komagataella pastoris. Expression_system_taxid: 4922 Chain: U (245 residues)
7zrr		Crystal structure of human urokinase-type plasminogen activator in complex with bicycle peptide inhibitor uk965 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: human embryonic kidney cells. Expression_system_cell_line: human embryonic kidney cells Chain: A (247 residues)
7zrt		Crystal structure of human urokinase-type plasminogen activator in complex with bicycle peptide inhibitor uk970 Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: homo sapiens. Expression_system_taxid: 9606. Expression_system_cell_line: human embryonic kidney 293. Synthetic: yes. Synthetic construct. Chain: A (247 residues)
9pyf		Upa inhibitory fab ab2 complex Source: Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Human. Gene: plau. Expressed in: escherichia coli k-12. Expression_system_taxid: 83333. Expression_system_taxid: 469008 Chain: F (247 residues)