EC 3.4.21.73 - U-plasminogen activator

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IntEnz Enzyme Nomenclature
EC 3.4.21.73

Names

Accepted name:
u-plasminogen activator
Other names:
abbokinase
cellular plasminogen activator
double-chain urokinase-type plasminogen activator
two-chain urokinase-type plasminogen activator
u-PA
uPA
urinary esterase A
urinary plasminogen activator
urokinase
urokinase plasminogen activator
urokinase-type plasminogen activator
Systematic name:
-

Reaction

Comments:

Formed from the inactive precursor by action of plasmin or plasma kallikrein. Differs in structure from t-plasminogen activator (EC 3.4.21.68), and does not bind to fibrin. In peptidase family S1 (trypsin family). Formerly included in EC 3.4.21.31 and EC 3.4.99.26.

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , MEROPS , UniPathway
Protein domains and families: PROSITE:PDOC00124
Structural data: CSA , EC2PDB
Gene Ontology: GO:0008243
CAS Registry Number: 9039-53-6
UniProtKB/Swiss-Prot:

References

  1. Lottenberg, R., Christiansen, U., Jackson, C.M. and Coleman, P.L.
    Assay of coagulation proteases using peptide chromogenic and fluorogenic substrates.
    Methods Enzymol. 80C: 341-361 (1981). [PMID: 6210826]
  2. Loskutoff, D.J. and Schleef, R.R.
    Plasminogen activators and their inhibitors.
    Methods Enzymol. 163: 293-302 (1988). [PMID: 3148826]
  3. Saksela, O. and Rifkin, D.B.
    Cell-associated plasminogen activation: regulation and physiological functions.
    Annu. Rev. Cell Biol. 4: 93-126 (1988). [PMID: 3143380]
  4. Collen, D., Lijnen, H.R. and Verstraete, M.
    The fibrinolytic system and its disorders.
    In: Handin, R.I., Lux, S.E. and Stossel, J.P. (Eds.) Blood: Principles and Practice of Hematology, 2nd ed., J.B. Lippincott Company, Philadelphia, 1990
  5. Lijnen, H.R., Van Hoef, B., Nelles, L. and Collen, D.
    Plasminogen activation with single-chain urokinase-type plasminogen activator (scu-PA). Studies with active site mutagenized plasminogen (Ser740→Ala) and plasmin-resistant scu-PA (Lys158→Glu).
    J. Biol. Chem. 265: 5232-5236 (1990). [PMID: 1969415]

[EC 3.4.21.73 created 1972 as EC 3.4.99.26, transferred 1978 as EC 3.4.21.31, part transferred 1992 to EC 3.4.21.73]