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PDBsum entry 7h2c
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Viral protein
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PDB id
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7h2c
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PDB id:
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| Name: |
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Viral protein
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Title:
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Pandda analysis group deposition -- crystal structure of zikv ns2b-ns3 protease in complex with z1328968520
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Structure:
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Serine protease subunit ns2b. Chain: a. Synonym: flavivirin protease ns2b regulatory subunit,non-structural protein 2b. Engineered: yes. Serine protease ns3. Chain: b. Synonym: flavivirin protease ns3 catalytic subunit,non-structural protein 3.
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Source:
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Zika virus. Organism_taxid: 64320. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562
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Resolution:
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1.40Å
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R-factor:
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0.223
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R-free:
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0.249
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Authors:
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X.Ni,A.S.Godoy,P.G.Marples,M.Fairhead,B.H.Balcomb,C.W.E.Tomlinson, L.Koekemoer,J.C.Aschenbrenner,R.M.Lithgo,W.Thompson,C.Wild, E.P.Williams,M.Winokan,A.V.Chandran,D.Fearon,M.A.Walsh,F.Von Delft
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Key ref:
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X.Ni
et al.
Pandda analysis group deposition of zikv ns2b-Ns3 pro.
To be published,
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Date:
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03-Apr-24
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Release date:
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08-May-24
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PROCHECK
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Headers
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References
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Enzyme class 1:
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Chains A, B:
E.C.2.1.1.56
- mRNA (guanine-N(7))-methyltransferase.
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Reaction:
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a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L- methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine
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5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA
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+
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S-adenosyl-L- methionine
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=
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5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA
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+
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S-adenosyl-L-homocysteine
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Enzyme class 2:
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Chains A, B:
E.C.2.1.1.57
- methyltransferase cap1.
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Reaction:
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a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)- (2'-O-methyl-ribonucleoside) in mRNA + S-adenosyl-L-homocysteine + H+
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5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA
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+
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S-adenosyl-L-methionine
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=
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5'-end (N(7)-methyl 5'-triphosphoguanosine)- (2'-O-methyl-ribonucleoside) in mRNA
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+
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S-adenosyl-L-homocysteine
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+
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H(+)
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Enzyme class 3:
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Chains A, B:
E.C.2.7.7.48
- RNA-directed Rna polymerase.
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Reaction:
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RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate
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RNA(n)
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+
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ribonucleoside 5'-triphosphate
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=
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RNA(n+1)
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+
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diphosphate
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Enzyme class 4:
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Chains A, B:
E.C.3.4.21.91
- flavivirin.
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Reaction:
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Selective hydrolysis of Xaa-Xaa-|-Xbb bonds in which each of the Xaa can be either Arg or Lys and Xbb can be either Ser or Ala.
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Enzyme class 5:
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Chains A, B:
E.C.3.6.1.15
- nucleoside-triphosphate phosphatase.
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Reaction:
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a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H+
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ribonucleoside 5'-triphosphate
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+
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H2O
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=
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ribonucleoside 5'-diphosphate
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+
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phosphate
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+
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H(+)
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Enzyme class 6:
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Chains A, B:
E.C.3.6.4.13
- Rna helicase.
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Reaction:
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ATP + H2O = ADP + phosphate + H+
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ATP
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+
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H2O
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=
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ADP
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+
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phosphate
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+
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H(+)
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Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
