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PDBsum entry 7fro
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PDB id:
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Hydrolase
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Title:
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Pandda analysis group deposition -- crystal structure of ptp1b in complex with z744754722
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Structure:
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Tyrosine-protein phosphatase non-receptor type 1. Chain: a. Fragment: catalytic domain. Synonym: protein-tyrosine phosphatase 1b,ptp-1b. Engineered: yes. Mutation: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: ptpn1, ptp1b. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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1.93Å
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R-factor:
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0.159
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R-free:
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0.188
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Authors:
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T.Mehlman,J.Biel,S.M.Azeem,E.R.Nelson,S.Hossain,L.E.Dunnett, N.G.Paterson,A.Douangamath,R.Talon,D.Axford,H.Orins,F.Von Delft, D.A.Keedy
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Key ref:
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T.Skaist mehlman
et al.
(2023).
Room-Temperature crystallography reveals altered bind small-Molecule fragments to ptp1b..
Elife,
12,
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PubMed id:
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Date:
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24-Oct-22
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Release date:
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23-Nov-22
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PROCHECK
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Headers
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References
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P18031
(PTN1_HUMAN) -
Tyrosine-protein phosphatase non-receptor type 1 from Homo sapiens
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Seq:
Struc:
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435 a.a.
281 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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*
PDB and UniProt seqs differ
at 2 residue positions (black
crosses)
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Enzyme class:
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E.C.3.1.3.48
- protein-tyrosine-phosphatase.
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Reaction:
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O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate
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O-phospho-L-tyrosyl-[protein]
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+
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H2O
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=
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L-tyrosyl-[protein]
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+
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phosphate
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
