PDBsum entry 7ed5

Viral protein

PDB id: 7ed5

Contents

Protein chains

926 a.a.

150 a.a.

72 a.a.

DNA/RNA

Ligands

AT9 ×3

Metals

_MG ×3

_ZN ×2

PDB id:

7ed5

Name:

Viral protein

Title:

A dual mechanism of action of at-527 against sars-cov-2 polymerase

Structure:

RNA-directed RNA polymerase. Chain: a. Synonym: pol,rdrp,non-structural protein 12,nsp12. Engineered: yes. Non-structural protein 8. Chain: b, d. Synonym: nsp8. Engineered: yes. Non-structural protein 7.

Source:

Severe acute respiratory syndrome coronavirus 2. Organism_taxid: 2697049. Gene: rep, 1a-1b. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes.

Authors:

A.Shannon,V.Fattorini,B.Sama,B.Selisko,M.Feracci,C.Falcou,P.Gauffre, P.El Kazzi,A.Delpal,E.Decroly,K.Alvarez,C.Eydoux,J.-C.Guillemot, A.Moussa,S.Good,P.Colla,K.Lin,J.-P.Sommadossi,Y.X.Zhu,X.D.Yan,H.Shi, F.Ferron,B.Canard

Key ref:

A.Shannon et al. (2022). A dual mechanism of action of at-527 against sars-Cov polymerase.. Nat commun, 13, 621. PubMed id: 35110538

Date:

15-Mar-21 Release date: 16-Feb-22

Protein chain

P0DTD1  (R1AB_SARS2) -

Protein chains

P0DTD1  (R1AB_SARS2) -

Protein chain

P0DTD1  (R1AB_SARS2) -

DNA/RNA chains

G-C-U-A-U-G-U-G-A-G-A-U-U-A-A-G-U-U-A-U 20 bases

C-C-C-C-A-U-A-A-C-U-U-A-A-U-C-U-C-A-C-A-U-A-G-C 24 bases

Enzyme reactions

• Enzyme class: Chain A: E.C.2.7.7.48 - RNA-directed Rna polymerase.
• Reaction: RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site