PDBsum entry 6uwc

Hydrolase/hydrolase inhibitor

PDB id: 6uwc

Contents

Protein chains

99 a.a.

Ligands

QK1

Waters ×105

PDB id:

6uwc

Name:

Hydrolase/hydrolase inhibitor

Title:

X-ray crystal structure of wild type HIV-1 protease in complex with grl-08613

Structure:

Protease. Chain: a, b. Engineered: yes

Source:

Human immunodeficiency virus 1. Organism_taxid: 11676. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.95Å R-factor: 0.205 R-free: 0.255

Authors:

R.S.Yedidi,H.Hayashi,A.K.Ghosh,H.Mitsuya

Key ref:

M.Amano et al. Fluoride-Modifications contribute to potent anti-Hiv activity against drug-Resistant HIV-1 and favorable blood-Brain barrier penetration property of novel cen nervous system (cns)-Targeting HIV-1 protease inhibit (pis) in vitro.. To be published, . PubMed id: 34978889

Date:

05-Nov-19 Release date: 18-Nov-20

Protein chains

P03367  (POL_HV1BR) -  Gag-Pol polyprotein from Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)

Seq: 1447 a.a.

Struc: 99 a.a.

Enzyme reactions

• Enzyme class 1: E.C.2.7.7.49 - RNA-directed Dna polymerase.
• Reaction: DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate
• Enzyme class 2: E.C.2.7.7.7 - DNA-directed Dna polymerase.
• Reaction: DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate
• Enzyme class 3: E.C.3.1.13.2 - exoribonuclease H.
• Reaction: Exonucleolytic cleavage to 5'-phosphomonoester oligonucleotides in both 5'- to 3'- and 3'- to 5'-directions.
• Enzyme class 4: E.C.3.1.26.13 - retroviral ribonuclease H.
• Enzyme class 5: E.C.3.4.23.16 - HIV-1 retropepsin.
• Reaction: Specific for a P1 residue that is hydrophobic, and P1' variable, but often Pro.

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site