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PDBsum entry 3nfh
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Transcription, DNA binding protein
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PDB id
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3nfh
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Contents |
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* Residue conservation analysis
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PDB id:
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| Name: |
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Transcription, DNA binding protein
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Title:
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Crystal structure of tandem winged helix domain of RNA polymerase i subunit a49 (p4)
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Structure:
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DNA-directed RNA polymerase i subunit rpa49. Chain: a, b. Fragment: unp residues 154-399. Synonym: a49, DNA-directed RNA polymerase i 49 kda polypeptide. Engineered: yes
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Source:
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Saccharomyces cerevisiae. Yeast. Organism_taxid: 4932. Gene: n0880, rpa49, rrn13, ynl248c. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Resolution:
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2.17Å
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R-factor:
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0.190
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R-free:
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0.225
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Authors:
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S.R.Geiger,K.Lorenzen,A.Schreieck,P.Hanecker,D.Kostrewa,A.J.R.Heck, P.Cramer
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Key ref:
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S.R.Geiger
et al.
(2010).
RNA polymerase I contains a TFIIF-related DNA-binding subcomplex.
Mol Cell,
39,
583-594.
PubMed id:
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Date:
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10-Jun-10
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Release date:
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08-Sep-10
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PROCHECK
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Headers
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References
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Q01080
(RPA49_YEAST) -
DNA-directed RNA polymerase I subunit RPA49 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
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Seq:
Struc:
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415 a.a.
207 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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Enzyme class:
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E.C.2.7.7.6
- DNA-directed Rna polymerase.
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Reaction:
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RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate
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RNA(n)
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+
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ribonucleoside 5'-triphosphate
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=
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RNA(n+1)
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+
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diphosphate
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Mol Cell
39:583-594
(2010)
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PubMed id:
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RNA polymerase I contains a TFIIF-related DNA-binding subcomplex.
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S.R.Geiger,
K.Lorenzen,
A.Schreieck,
P.Hanecker,
D.Kostrewa,
A.J.Heck,
P.Cramer.
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ABSTRACT
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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S.Grünberg,
L.Warfield,
and
S.Hahn
(2012).
Architecture of the RNA polymerase II preinitiation complex and mechanism of ATP-dependent promoter opening.
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Nat Struct Mol Biol,
19,
788-796.
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B.Albert,
I.Léger-Silvestre,
C.Normand,
M.K.Ostermaier,
J.Pérez-Fernández,
K.I.Panov,
J.C.Zomerdijk,
P.Schultz,
and
O.Gadal
(2011).
RNA polymerase I-specific subunits promote polymerase clustering to enhance the rRNA gene transcription cycle.
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J Cell Biol,
192,
277-293.
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F.Werner,
and
D.Grohmann
(2011).
Evolution of multisubunit RNA polymerases in the three domains of life.
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Nat Rev Microbiol,
9,
85-98.
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L.A.Lane,
C.Fernández-Tornero,
M.Zhou,
N.Morgner,
D.Ptchelkine,
U.Steuerwald,
A.Politis,
D.Lindner,
J.Gvozdenovic,
A.C.Gavin,
C.W.Müller,
and
C.V.Robinson
(2011).
Mass spectrometry reveals stable modules in holo and apo RNA polymerases I and III.
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Structure,
19,
90.
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S.Lefèvre,
H.Dumay-Odelot,
L.El-Ayoubi,
A.Budd,
P.Legrand,
N.Pinaud,
M.Teichmann,
and
S.Fribourg
(2011).
Structure-function analysis of hRPC62 provides insights into RNA polymerase III transcription initiation.
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Nat Struct Mol Biol,
18,
352-358.
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PDB codes:
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
codes are
shown on the right.
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Links
