EC 2.7.7.6 - DNA-directed RNA polymerase

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IntEnz Enzyme Nomenclature
EC 2.7.7.6

Names

Accepted name:
DNA-directed RNA polymerase
Other names:
C RNA formation factors
C ribonucleic acid formation factors
DNA-dependent RNA nucleotidyltransferase
DNA-dependent RNA polymerase
DNA-dependent ribonucleate nucleotidyltransferase
RNA nucleotidyltransferase
RNA nucleotidyltransferase (DNA-directed)
RNA polymerase
RNA polymerase I
RNA polymerase II
RNA polymerase III
RNA transcriptase
deoxyribonucleic acid-dependent ribonucleic acid polymerase
ribonucleate nucleotidyltransferase
ribonucleate polymerase
ribonucleic acid nucleotidyltransferase
ribonucleic acid polymerase
ribonucleic acid transcriptase
ribonucleic polymerase
ribonucleic transcriptase
transcriptase
Systematic name:
nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed)

Reaction

Comments:

Catalyses DNA-template-directed extension of the 3'- end of an RNA strand by one nucleotide at a time. Can initiate a chain de novo. In eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to α-amanitin, and the type of RNA synthesized. See also EC 2.7.7.19 (polynucleotide adenyltransferase) and EC 2.7.7.48 (RNA-directed RNA polymerase).

Links to other databases

Enzymes and pathways: NC-IUBMB , BRENDA , ExplorEnz , ENZYME@ExPASy , KEGG , MetaCyc , UniPathway
Protein domains and families: PROSITE:PDOC00106 , PROSITE:PDOC00410 , PROSITE:PDOC00411 , PROSITE:PDOC00790 , PROSITE:PDOC00854 , PROSITE:PDOC00855 , PROSITE:PDOC00856 , PROSITE:PDOC00889 , PROSITE:PDOC00896
Structural data: CSA , EC2PDB
Gene Ontology: GO:0003899
CAS Registry Number: 9014-24-8
UniProtKB/Swiss-Prot: (3840) [show] [UniProt]