PDBsum entry 3qql

Transferase/transferase inhibitor

PDB id: 3qql

Contents

Protein chain

294 a.a.

Ligands

X03

Waters ×242

PDB id:

3qql

Name:

Transferase/transferase inhibitor

Title:

Cdk2 in complex with inhibitor l3

Structure:

Cyclin-dependent kinase 2. Chain: a. Synonym: cdk2, cell division protein kinase 2, p33 protein kinase. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.85Å R-factor: 0.184 R-free: 0.224

Authors:

S.Betzi,R.Alam,H.Han,A.Becker,E.Schonbrunn

Key ref:

E.Schonbrunn et al. Structure-Guided optimization of novel cdk2 inhibitor discovered by high-Throughput screening. To be published, .

Date:

15-Feb-11 Release date: 08-Aug-12

Protein chain

P24941  (CDK2_HUMAN) -  Cyclin-dependent kinase 2 from Homo sapiens

Seq: 298 a.a.

Struc: 294 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.11.22 - cyclin-dependent kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site