EC 2.7.11.22 - cyclin-dependent kinase.

_EC 2.7.11.22 cyclin-dependent kinase.

708 PDB entries

EC 2.-.-.- Transferases. [47,727 PDB entries]

EC 2.7.-.- Transferring phosphorus-containing groups. [28,060 PDB entries]

EC 2.7.11.- Protein-serine/threonine kinases. [7,384 PDB entries]

EC 2.7.11.22 cyclin-dependent kinase. [708 PDB entries]

1aq1

Reaction: (1) L-seryl-[protein] + Atp = O-phospho-L-seryl-[protein] + adp + H(+). (2) L-threonyl-[protein] + Atp = O-phospho-L-threonyl-[protein] + adp + H(+).

L-seryl-[protein]
+
ATP
= O-phospho-L-seryl-[protein]
+
ADP
+ H(+)

L-threonyl-[protein]
+
ATP
= O-phospho-L-threonyl-[protein]
+
ADP
+ H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site.

Other name(s): cdc2 kinase. cdk-activating kinase. Cdk-activating protein kinase.

Comments: Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. Formerly Ec 2.7.1.37.

Links: [IntEnz] [ExPASy] [KEGG]

There are 708 PDB entries in enzyme class E.C.2.7.11.22

PDB code Protein

1aq1

Human cyclin dependent kinase 2 complexed with the inhibitor staurosporine

Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: sf9. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (277 residues) CATH domains: 3.30.200.20 1.10.510.10

1b38

Human cyclin-dependent kinase 2

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (291 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ATP corresponds to enzyme reactant ATP

Het Group ATP corresponds to enzyme reactant ATP

1b39

Human cyclin-dependent kinase 2 phosphorylated on thr 160

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (291 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ATP corresponds to enzyme reactant ATP

Het Group ATP corresponds to enzyme reactant ATP

1bi7

Mechanism of g1 cyclin dependent kinase inhibition from the structure of the cdk6-p16ink4a tumor suppressor complex

Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: spodoptera frugiperda. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (269 residues) CATH domains: 3.30.200.20 1.10.510.10

1bi8

Mechanism of g1 cyclin dependent kinase inhibition from the structures cdk6-p19ink4d inhibitor complex

Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: spodoptera frugiperda. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, C (264 residues) CATH domains: 3.30.200.20 1.10.510.10

1blx

P19ink4d/cdk6 complex

Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: sf9. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Mus musculus. House mouse.

Chain: A (305 residues) CATH domains: 3.30.200.20 1.10.510.10

1buh

Crystal structure of the human cdk2 kinase complex with cell cycle- regulatory protein ckshs1

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (287 residues) CATH domains: 3.30.200.20 1.10.510.10

1ckp

Human cyclin dependent kinase 2 complexed with the inhibitor purvalanol b

Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: sf9. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (279 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group PVB is 50.00% similar to enzyme product ADP

Het Group PVB is 50.00% similar to enzyme product ADP

1di8

The structure of cyclin-dependent kinase 2 (cdk2) in complex with 4- [3-hydroxyanilino]-6,7-dimethoxyquinazoline

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469. Expression_system_cell: t.Ni

Chain: A (283 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group DTQ is 40.00% similar to enzyme product ADP

Het Group DTQ is 40.00% similar to enzyme product ADP

1dm2

Human cyclin-dependent kinase 2 complexed with the inhibitor hymenialdisine

Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: sf9 cells. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (274 residues) CATH domains: 3.30.200.20 1.10.510.10

1e1v

Human cyclin dependent kinase 2 complexed with the inhibitor nu2058

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (291 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group CMG is 40.62% similar to enzyme product ADP

Het Group CMG is 40.62% similar to enzyme product ADP

1e1x

Human cyclin dependent kinase 2 complexed with the inhibitor nu6027

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (291 residues) CATH domains: 3.30.200.20 1.10.510.10

1e9h

Thr 160 phosphorylated cdk2 - human cyclin a3 complex with the inhibitor indirubin-5-sulphonate bound

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562

Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10

1f5q

Crystal structure of murine gamma herpesvirus cyclin complexed to human cyclin dependent kinase 2

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9 insect cells. Murid herpesvirus 4. Murine herpesvirus 68. Organism_taxid: 33708.

Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10

1fin

Cyclin a-cyclin-dependent kinase 2 complex

Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: sf9. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: the fragment used in the crystallization was produced

Chains: A, C (298 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ATP corresponds to enzyme reactant ATP

Het Group ATP corresponds to enzyme reactant ATP

1fq1

Crystal structure of kinase associated phosphatase (kap) in complex with phospho-cdk2

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: homo sapiens. Other_details: homo sapiens

Chain: B (296 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ATP corresponds to enzyme reactant ATP

Het Group ATP corresponds to enzyme reactant ATP

1fvt

The structure of cyclin-dependent kinase 2 (cdk2) in complex with an oxindole inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (282 residues) CATH domains: 3.30.200.20 1.10.510.10

1fvv

The structure of cdk2/cyclin a in complex with an oxindole inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562

Chains: A, C (298 residues) CATH domains: 3.30.200.20 1.10.510.10

1g3n

Structure of a p18(ink4c)-cdk6-k-cyclin ternary complex

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cyclin-dependent kinase 6. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469. Gene: p18(ink4c). Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, E (293 residues) CATH domains: 3.30.200.20 1.10.510.10

1g5s

Crystal structure of human cyclin dependent kinase 2 (cdk2) in complex with the inhibitor h717

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: A (275 residues) CATH domains: 3.30.200.20 1.10.510.10

1gih

Human cyclin dependent kinase 2 complexed with the cdk4 inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Chain: A (276 residues) CATH domains: 3.30.200.20 1.10.510.10

1gii

Human cyclin dependent kinase 2 complexed with the cdk4 inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Chain: A (279 residues) CATH domains: 3.30.200.20 1.10.510.10

1gij

Human cyclin dependent kinase 2 complexed with the cdk4 inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Chain: A (273 residues) CATH domains: 3.30.200.20 1.10.510.10

1gy3

Pcdk2/cyclin a in complex with mgadp, nitrate and peptide substrate

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: cdk2 was co-expressed with cak1 - produce thr160- phospho-cdk2. Synthetic: yes. Synthetic construct.

Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ATP corresponds to enzyme product ADP

Het Group ATP corresponds to enzyme product ADP

1gz8

Human cyclin dependent kinase 2 complexed with the inhibitor 2-amino- 6-(3'-methyl-2'-oxo)butoxypurine

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (291 residues) CATH domains: 3.30.200.20 1.10.510.10

1h00

Cdk2 in complex with a disubstituted 4, 6-bis anilino pyrimidine cdk4 inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: A (279 residues) CATH domains: 3.30.200.20 1.10.510.10

1h01

Cdk2 in complex with a disubstituted 2, 4-bis anilino pyrimidine cdk4 inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: A (287 residues) CATH domains: 3.30.200.20 1.10.510.10

1h07

Cdk2 in complex with a disubstituted 4, 6-bis anilino pyrimidine cdk4 inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: A (286 residues) CATH domains: 3.30.200.20 1.10.510.10

1h08

Cdk2 in complex with a disubstituted 2, 4-bis anilino pyrimidine cdk4 inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: A (284 residues) CATH domains: 3.30.200.20 1.10.510.10

1h0v

Human cyclin dependent protein kinase 2 in complex with the inhibitor 2-amino-6-[(r)-pyrrolidino-5'-yl]methoxypurine

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (288 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group UN4 is 40.62% similar to enzyme product ADP

Het Group UN4 is 40.62% similar to enzyme product ADP

1h0w

Human cyclin dependent protein kinase 2 in complex with the inhibitor 2-amino-6-[cyclohex-3-enyl]methoxypurine

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (283 residues) CATH domains: 3.30.200.20 1.10.510.10

1h1p

Structure of human thr160-phospho cdk2/cyclin a complexed with the inhibitor nu2058

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562

Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligand: Het Group CMG is 40.62% similar to enzyme product ADP

1h1q

Structure of human thr160-phospho cdk2/cyclin a complexed with the inhibitor nu6094

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562

Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group 2A6 is 41.67% similar to enzyme product ADP

Het Group 2A6 is 41.67% similar to enzyme product ADP

1h1r

Structure of human thr160-phospho cdk2/cyclin a complexed with the inhibitor nu6086

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562

Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group 6CP is 40.54% similar to enzyme product ADP

Het Group 6CP is 40.54% similar to enzyme product ADP

1h1s

Structure of human thr160-phospho cdk2/cyclin a complexed with the inhibitor nu6102

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562

Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10

1h24

Cdk2/cyclina in complex with a 9 residue recruitment peptide from e2f

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606

Chains: A, C (294 residues) CATH domains: 3.30.200.20 1.10.510.10

1h25

Cdk2/cyclin a in complex with an 11-residue recruitment peptide from retinoblastoma-associated protein

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606

Chains: A, C (294 residues) CATH domains: 3.30.200.20 1.10.510.10

1h26

Cdk2/cyclina in complex with an 11-residue recruitment peptide from p53

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606

Chains: A, C (298 residues) CATH domains: 3.30.200.20 1.10.510.10

1h27

Cdk2/cyclina in complex with an 11-residue recruitment peptide from p27

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606

Chains: A, C (298 residues) CATH domains: 3.30.200.20 1.10.510.10

1h28

Cdk2/cyclina in complex with an 11-residue recruitment peptide from p107

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606

Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10

1hck

Human cyclin-dependent kinase 2

Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: sf9. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ATP corresponds to enzyme reactant ATP

Het Group ATP corresponds to enzyme reactant ATP

1hcl

Human cyclin-dependent kinase 2

Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: sf9. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

1jow

Crystal structure of a complex of human cdk6 and a viral cyclin

Source: Saimiriine herpesvirus 2. Herpesvirus saimiri. Organism_taxid: 10381. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Homo sapiens. Human. Organism_taxid: 9606.

Chain: B (277 residues) CATH domains: 3.30.200.20 1.10.510.10

1jst

Phosphorylated cyclin-dependent kinase-2 bound to cyclin a

Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: sf9. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Other_details: cyclin a-bound form phosphorylated on thr 160 in vitro using a cdk-activating kinase consisting of the cyclinh-cdk7 complex.

Chains: A, C (298 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ATP corresponds to enzyme reactant ATP

Het Group ATP corresponds to enzyme reactant ATP

1jsu

P27(kip1)/cyclin a/cdk2 complex

Source: Homo sapiens. Human. Organism_taxid: 9606. Cell_line: sf9. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Other_details: cyclin a-bound form phosphorylated on thr 160 in vitro using a cdk-activating kinase consisting of the cyclinh-cdk7

Chain: A (286 residues) CATH domains: 3.30.200.20 1.10.510.10

1jsv

The structure of cyclin-dependent kinase 2 (cdk2) in complex with 4- [(6-amino-4-pyrimidinyl)amino]benzenesulfonamide

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: high-five insect cells.

Chain: A (288 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group U55 is 40.62% similar to enzyme product ADP

Het Group U55 is 40.62% similar to enzyme product ADP

1jvp

Crystal structure of human cdk2 (unphosphorylated) in complex with pkf049-365

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: h5 (trichoplusia ni).

Chain: P (281 residues) CATH domains: 3.30.200.20 1.10.510.10

1ke5

Cdk2 complexed with n-methyl-4-{[(2-oxo-1,2-dihydro-3h-indol-3- ylidene)methyl]amino}benzenesulfonamide

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (281 residues) CATH domains: 3.30.200.20 1.10.510.10

1ke6

Cyclin-dependent kinase 2 (cdk2) complexed with n-methyl-{4-[2-(7-oxo- 6,7-dihydro-8h-[1,3]thiazolo[5,4-e]indol-8-ylidene) hydrazino]phenyl}methanesulfonamide

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (280 residues) CATH domains: 3.30.200.20 1.10.510.10

1ke7

Cyclin-dependent kinase 2 (cdk2) complexed with 3-{[(2,2-dioxido-1,3- dihydro-2-benzothien-5-yl)amino]methylene}-5-(1,3-oxazol-5-yl)-1,3- dihydro-2h-indol-2-one

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (281 residues) CATH domains: 3.30.200.20 1.10.510.10

1ke8

Cyclin-dependent kinase 2 (cdk2) complexed with 4-{[(2-oxo-1,2- dihydro-3h-indol-3-ylidene)methyl]amino}-n-(1,3-thiazol-2-yl) benzenesulfonamide

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (282 residues) CATH domains: 3.30.200.20 1.10.510.10

1ke9

Cyclin-dependent kinase 2 (cdk2) complexed with 3-{[4-({[amino(imino) methyl]aminosulfonyl)anilino]methylene}-2-oxo-2,3-dihydro-1h-indole

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (281 residues) CATH domains: 3.30.200.20 1.10.510.10

1ob3

Structure of p. Falciparum pfpk5

Source: Plasmodium falciparum. Organism_taxid: 5833. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chains: A, B (277 residues) CATH domains: 3.30.200.20 1.10.510.10

1ogu

Structure of human thr160-phospho cdk2/cyclin a complexed with a 2- arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562

Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10

1oi9

Structure of human thr160-phospho cdk2/cyclin a complexed with a 6- cyclohexylmethyloxy-2-anilino-purine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562

Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group N20 is 44.44% similar to enzyme product ADP

Het Group N20 is 44.44% similar to enzyme product ADP

1oiq

Imidazopyridines: a potent and selective class of cyclin-dependent kinase inhibitors identified through structure-based hybridisation

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: A (264 residues) CATH domains: 3.30.200.20 1.10.510.10

1oir

Imidazopyridines: a potent and selective class of cyclin-dependent kinase inhibitors identified through structure-based hybridisation

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: A (287 residues) CATH domains: 3.30.200.20 1.10.510.10

1oit

Imidazopyridines: a potent and selective class of cyclin-dependent kinase inhibitors identified through structure-based hybridisation

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: A (273 residues) CATH domains: 3.30.200.20 1.10.510.10

1oiu

Structure of human thr160-phospho cdk2/cyclin a complexed with a 6- cyclohexylmethyloxy-2-anilino-purine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562

Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10

1oiy

Structure of human thr160-phospho cdk2/cyclin a complexed with a 6- cyclohexylmethyloxy-2-anilino-purine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562

Chains: A, C (294 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group N41 is 42.11% similar to enzyme product ADP

Het Group N41 is 42.11% similar to enzyme product ADP

1okv

Cyclin a binding groove inhibitor h-arg-arg-leu-ile-phe-nh2

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic construct.

Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10

1okw

Cyclin a binding groove inhibitor ac-arg-arg-leu-asn-(m-cl-phe)-nh2

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic construct.

Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10

1ol1

Cyclin a binding groove inhibitor h-cit-cit-leu-ile-(p-f-phe)-nh2

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic construct.

Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10

1ol2

Cyclin a binding groove inhibitor h-arg-arg-leu-asn-(p-f-phe)-nh2

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: cyclin groove-bound peptide h-arg-arg-leu-asn-(p-f- phe)-nh2.

Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10

1p2a

The structure of cyclin dependent kinase 2 (ckd2) with a trisubstituted naphthostyril inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469

Chain: A (271 residues) CATH domains: 3.30.200.20 1.10.510.10

1p5e

The structure of phospho-cdk2/cyclin a in complex with the inhibitor 4,5,6,7-tetrabromobenzotriazole (tbs)

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccna2 or ccna or ccn1.

Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10

1pf8

Crystal structure of human cyclin-dependent kinase 2 complexed with a nucleoside inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (298 residues) CATH domains: 3.30.200.20 1.10.510.10

1pkd

The crystal structure of ucn-01 in complex with phospho-cdk2/cyclin a

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccna2 or ccna or ccn1.

Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10

1pw2

Apo structure of human cyclin-dependent kinase 2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

1pxi

Human cyclin dependent kinase 2 complexed with the inhibitor 4-(2,5- dichloro-thiophen-3-yl)-pyrimidin-2-ylamine

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

1pxj

Human cyclin dependent kinase 2 complexed with the inhibitor 4-(2,4- dimethyl-thiazol-5-yl)-pyrimidin-2-ylamine

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

1pxk

Human cyclin dependent kinase 2 complexed with the inhibitor n-[4-(2, 4-dimethyl-thiazol-5-yl)pyrimidin-2-yl]-n'-hydroxyiminoformamide

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: A (290 residues) CATH domains: 3.30.200.20 1.10.510.10

1pxl

Human cyclin dependent kinase 2 complexed with the inhibitor [4-(2,4- dimethyl-thiazol-5-yl)-pyrimidin-2-yl]-(4-trifluoromethyl-phenyl)- amine

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: A (290 residues) CATH domains: 3.30.200.20 1.10.510.10

1pxm

Human cyclin dependent kinase 2 complexed with the inhibitor 3-[4-(2, 4-dimethyl-thiazol-5-yl)-pyrimidin-2-ylamino]-phenol

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: hi5.

Chain: A (290 residues) CATH domains: 3.30.200.20 1.10.510.10

1pxn

Human cyclin dependent kinase 2 complexed with the inhibitor 4-[4-(4- methyl-2-methylamino-thiazol-5-yl)-pyrimidin-2-ylamino]-phenol

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: hi5.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

1pxo

Human cyclin dependent kinase 2 complexed with the inhibitor [4-(2- amino-4-methyl-thiazol-5-yl)-pyrimidin-2-yl]-(3-nitro-phenyl)-amine

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: hi5.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

1pxp

Human cyclin dependent kinase 2 complexed with the inhibitor n-[4-(2, 4-dimethyl-thiazol-5-yl)-pyrimidin-2-yl]-n',n'-dimethyl-benzene-1,4- diamine

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: hi5.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

1pye

Crystal structure of cdk2 with inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (266 residues) CATH domains: 3.30.200.20 1.10.510.10

1qmz

Phosphorylated cdk2-cyclyin a-substrate peptide complex

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Other_details: cyclin a-bound form phosphorylated source coexpression with cak1p. Synthetic: yes. Organism_taxid: 9606

Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ATP corresponds to enzyme reactant ATP

Het Group ATP corresponds to enzyme reactant ATP

1r78

Cdk2 complex with a 4-alkynyl oxindole inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (273 residues) CATH domains: 3.30.200.20 1.10.510.10

1ua2

Crystal structure of human cdk7

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk7. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21. Other_details: sf21 cells in culture

Chains: A, B, C, D (287 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ATP corresponds to enzyme reactant ATP

Het Group ATP corresponds to enzyme reactant ATP

1urc

Cyclin a binding groove inhibitor ace-arg-lys-leu-phe-gly

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic construct.

Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10

1urw

Cdk2 in complex with an imidazo[1,2-b]pyridazine

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: A (275 residues) CATH domains: 3.30.200.20 1.10.510.10

1v0b

Crystal structure of the t198a mutant of pfpk5

Source: Plasmodium falciparum. Organism_taxid: 5833. Expressed in: escherichia coli. Expression_system_taxid: 562

Chains: A, B (287 residues) CATH domains: 3.30.200.20 1.10.510.10

1v0o

Structure of p. Falciparum pfpk5-indirubin-5-sulphonate ligand complex

Source: Plasmodium falciparum. Organism_taxid: 5833. Expressed in: escherichia coli. Expression_system_taxid: 562

Chains: A, B (277 residues) CATH domains: 3.30.200.20 1.10.510.10

1v0p

Structure of p. Falciparum pfpk5-purvalanol b ligand complex

Source: Plasmodium falciparum. Organism_taxid: 5833. Expressed in: escherichia coli. Expression_system_taxid: 562

Chains: A, B (277 residues) CATH domains: 3.30.200.20 1.10.510.10

1v1k

Cdk2 in complex with a disubstituted 4, 6-bis anilino pyrimidine cdk4 inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: A (278 residues) CATH domains: 3.30.200.20 1.10.510.10

1vyw

Structure of cdk2/cyclin a with pnu-292137

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: high five. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.

Chains: A, C (302 residues) CATH domains: 3.30.200.20 1.10.510.10

1vyz

Structure of cdk2 complexed with pnu-181227

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: high five.

Chain: A (279 residues) CATH domains: 3.30.200.20 1.10.510.10

1w0x

Crystal structure of human cdk2 in complex with the inhibitor olomoucine.

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: C (280 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group OLO is 44.12% similar to enzyme product ADP

Het Group OLO is 44.12% similar to enzyme product ADP

1w8c

Co-crystal structure of 6-cyclohexylmethoxy-8-isopropyl-9h-purin-2- ylamine and monomeric cdk2

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (292 residues) CATH domains: 3.30.200.20 1.10.510.10

1w98

The structural basis of cdk2 activation by cyclin e

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (298 residues) CATH domains: 3.30.200.20 1.10.510.10

1wcc

Screening for fragment binding by x-ray crystallography

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (283 residues) CATH domains: 3.30.200.20 1.10.510.10

1xo2

Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin

Source: Saimiriine herpesvirus 2. Herpesvirus saimiri. Organism_taxid: 10381. Gene: 72, eclf2. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_cell_line: sf-9. Homo sapiens. Human.

Chain: B (289 residues) CATH domains: 3.30.200.20 1.10.510.10

1y8y

Crystal structure of human cdk2 complexed with a pyrazolo[1,5- a]pyrimidine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: A (292 residues) CATH domains: 3.30.200.20 1.10.510.10

1y91

Crystal structure of human cdk2 complexed with a pyrazolo[1,5- a]pyrimidine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: A (286 residues) CATH domains: 3.30.200.20 1.10.510.10

1ykr

Crystal structure of cdk2 with an aminoimidazo pyridine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.

Chain: A (298 residues) CATH domains: 3.30.200.20 1.10.510.10

2a0c

Human cdk2 in complex with olomoucine ii, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2.

Chain: X (294 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group CK9 is 42.11% similar to enzyme product ADP

Het Group CK9 is 42.11% similar to enzyme product ADP

2a4l

Human cyclin-dependent kinase 2 in complex with roscovitine

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9 cells.

Chain: A (286 residues) CATH domains: 3.30.200.20 1.10.510.10

2b52

Human cyclin dependent kinase 2 (cdk2) complexed with dph-042562

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (283 residues) CATH domains: 3.30.200.20 1.10.510.10

2b53

Human cyclin dependent kinase 2 (cdk2) complexed with din-234325

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

2b54

Human cyclin dependent kinase 2 (ckd2)complexed with din-232305

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (298 residues) CATH domains: 3.30.200.20 1.10.510.10

2b55

Human cyclin dependent kinase 2 (cdk2) complexed with indenopyraxole din-101312

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (276 residues) CATH domains: 3.30.200.20 1.10.510.10

2bhe

Human cyclin dependent protein kinase 2 in complex with the inhibitor 5-bromo-indirubine

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Chain: A (274 residues) CATH domains: 3.30.200.20 1.10.510.10

2bhh

Human cyclin dependent protein kinase 2 in complex with the inhibitor 4-hydroxypiperindinesulfonyl-indirubine

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Chain: A (274 residues) CATH domains: 3.30.200.20 1.10.510.10

2bkz

Structure of cdk2-cyclin a with pha-404611

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high five. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.

Chains: A, C (302 residues) CATH domains: 3.30.200.20 1.10.510.10

2bpm

Structure of cdk2-cyclin a with pha-630529

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high five. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.

Chains: A, C (302 residues) CATH domains: 3.30.200.20 1.10.510.10

2btr

Structure of cdk2 complexed with pnu-198873

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high five.

Chain: A (275 residues) CATH domains: 3.30.200.20 1.10.510.10

2bts

Structure of cdk2 complexed with pnu-230032

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high five.

Chain: A (274 residues) CATH domains: 3.30.200.20 1.10.510.10

2c4g

Structure of cdk2-cyclin a with pha-533514

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high five. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.

Chains: A, C (301 residues) CATH domains: 3.30.200.20 1.10.510.10

2c5n

Differential binding of inhibitors to active and inactive cdk2 provides insights for drug design

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Expressed in: escherichia coli. Expression_system_taxid: 562

Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10

2c5o

Differential binding of inhibitors to active and inactive cdk2 provides insights for drug design

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expressed in: escherichia coli. Expression_system_taxid: 562

Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10

2c5v

Differential binding of inhibitors to active and inactive cdk2 provides insights for drug design

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes.

Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10

2c5x

Differential binding of inhibitors to active and inactive cdk2 provides insights for drug design

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Expressed in: escherichia coli. Expression_system_taxid: 562

Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10

2c5y

Differential binding of inhibitors to active and inactive cdk2 provides insights for drug design

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: A (290 residues) CATH domains: 3.30.200.20 1.10.510.10

2c68

Crystal structure of the human cdk2 complexed with the triazolopyrimidine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.

Chain: A (290 residues) CATH domains: 3.30.200.20 1.10.510.10

2c69

Crystal structure of the human cdk2 complexed with the triazolopyrimidine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.

Chain: A (292 residues) CATH domains: 3.30.200.20 1.10.510.10

2c6i

Crystal structure of the human cdk2 complexed with the triazolopyrimidine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.

Chain: A (292 residues) CATH domains: 3.30.200.20 1.10.510.10

2c6k

Crystal structure of the human cdk2 complexed with the triazolopyrimidine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.

Chain: A (292 residues) CATH domains: 3.30.200.20 1.10.510.10

2c6l

Crystal structure of the human cdk2 complexed with the triazolopyrimidine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.

Chain: A (291 residues) CATH domains: 3.30.200.20 1.10.510.10

2c6m

Crystal structure of the human cdk2 complexed with the triazolopyrimidine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.

Chain: A (290 residues) CATH domains: 3.30.200.20 1.10.510.10

2c6o

Crystal structure of the human cdk2 complexed with the triazolopyrimidine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.

Chain: A (290 residues) CATH domains: 3.30.200.20 1.10.510.10

2c6t

Crystal structure of the human cdk2 complexed with the triazolopyrimidine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.

Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10

2cch

The crystal structure of cdk2 cyclin a in complex with a substrate peptide derived from cdc modified with a gamma-linked atp analogue

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606

Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ATP corresponds to enzyme reactant ATP

Het Group ATP corresponds to enzyme reactant ATP

2cci

Crystal structure of phospho-cdk2 cyclin a in complex with a peptide containing both the substrate and recruitment sites of cdc6

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccna2, ccn1, ccna. Synthetic: yes. Organism_taxid: 9606

Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ATP corresponds to enzyme reactant ATP

Het Group ATP corresponds to enzyme reactant ATP

2cjm

Mechanism of cdk inhibition by active site phosphorylation: cdk2 y15p t160p in complex with cyclin a structure

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.

Chains: A, C (287 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ATP corresponds to enzyme reactant ATP

Het Group ATP corresponds to enzyme reactant ATP

2clx

4-arylazo-3,5-diamino-1h-pyrazole cdk inhibitors: sar study, crystal structure in complex with cdk2, selectivity, and cellular effects

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (293 residues) CATH domains: 3.30.200.20 1.10.510.10

2ds1

Human cyclin dependent kinase 2 complexed with the cdk4 inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (290 residues) CATH domains: 3.30.200.20 1.10.510.10

2duv

Structure of cdk2 with a 3-hydroxychromones

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Chain: A (272 residues) CATH domains: 3.30.200.20 1.10.510.10

2euf

X-ray structure of human cdk6-vcyclin in complex with the inhibitor pd0332991

Source: Herpesvirus saimiri (strain 11). Organism_taxid: 10383. Strain: 11. Gene: 72, eclf2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Homo sapiens. Human. Organism_taxid: 9606.

Chain: B (282 residues) CATH domains: 3.30.200.20 1.10.510.10

2exm

Human cdk2 in complex with isopentenyladenine

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Chain: A (298 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ZIP is 50.00% similar to enzyme product ADP

Het Group ZIP is 50.00% similar to enzyme product ADP

2f2c

X-ray structure of human cdk6-vcyclinwith the inhibitor aminopurvalanol

Source: Herpesvirus saimiri (strain 11). Organism_taxid: 10383. Strain: 11. Gene: 72, eclf2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Homo sapiens. Human. Organism_taxid: 9606.

Chain: B (280 residues) CATH domains: 3.30.200.20 1.10.510.10

2fvd

Cyclin dependent kinase 2 (cdk2) with diaminopyrimidine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469

Chain: A (284 residues) CATH domains: 3.30.200.20 1.10.510.10

2g9x

Structure of thr 160 phosphorylated cdk2/cyclin a in complex with the inhibitor nu6271

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562. Bos taurus. Cattle. Organism_taxid: 9913.

Chains: A, C (299 residues) CATH domains: 3.30.200.20 1.10.510.10

2i40

Cdk2/cyclin a complexed with a thiophene carboxamide inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccna2, ccn1, ccna. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.

Chains: A, C (291 residues) CATH domains: 3.30.200.20 1.10.510.10

2iw6

Structure of human thr160-phospho cdk2-cyclin a complexed with a bisanilinopyrimidine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: wild type gene was a gift from dr d.O.Morgan. Other_details: full-length cyclin a was a gift from dr m.Doree

Chains: A, C (293 residues) CATH domains: 3.30.200.20 1.10.510.10

2iw8

Structure of human thr160-phospho cdk2-cyclin a f82h-l83v-h84d mutant with an o6-cyclohexylmethylguanine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: wild type gene was a gift from dr d.O.Morgan. Other_details: full length cyclin a was a gift from dr m.Doree

Chains: A, C (298 residues) CATH domains: 3.30.200.20 1.10.510.10

2iw9

Structure of human thr160-phospho cdk2-cyclin a complexed with a bisanilinopyrimidine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Other_details: wild type gene was a gift from dr d.O.Morgan. Other_details: full length cyclin a was a gift from dr m.Doree

Chains: A, C (294 residues) CATH domains: 3.30.200.20 1.10.510.10

2j9m

Crystal structure of cdk2 in complex with macrocyclic aminopyrimidine

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: A (275 residues) CATH domains: 3.30.200.20 1.10.510.10

2jgz

Crystal structure of phospho-cdk2 in complex with cyclin b

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562

Chain: A (289 residues) CATH domains: 3.30.200.20 1.10.510.10

2jii

Structure of vaccinia related kinase 3

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: r3.

Chains: A, B (321 residues) CATH domains: 3.30.200.20 1.10.510.10

2pk9

Structure of the pho85-pho80 cdk-cyclin complex of the phosphate- responsive signal transduction pathway

Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: pho85, ssg3. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: pho80, ags3, tup7, vac5.

Chains: A, C (287 residues) CATH domains: 3.30.200.20 1.10.510.10

2pmi

Structure of the pho85-pho80 cdk-cyclin complex of the phosphate- responsive signal transduction pathway with bound atp-gamma-s

Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 4932. Gene: pho85, ssg3. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: pho80, ags3, tup7, vac5.

Chains: A, C (284 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group AGS is 93.75% similar to enzyme reactant ATP

Het Group AGS is 93.75% similar to enzyme reactant ATP

2qkr

Cryptosporidium parvum cyclin-dependent kinase cgd5_2510 with indirubin 3'-monoxime bound

Source: Cryptosporidium parvum iowa ii. Organism_taxid: 353152. Strain: iowa type ii. Gene: cgd5_2510. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (273 residues) CATH domains: 3.30.200.20 1.10.510.10

2r3f

Crystal structure of cyclin-dependent kinase 2 with inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.

Chain: A (292 residues) CATH domains: 3.30.200.20 1.10.510.10

2r3g

Crystal structure of cyclin-dependent kinase 2 with inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.

Chain: A (290 residues) CATH domains: 3.30.200.20 1.10.510.10

2r3h

Crystal structure of cyclin-dependent kinase 2 with inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.

Chain: A (292 residues) CATH domains: 3.30.200.20 1.10.510.10

2r3i

Crystal structure of cyclin-dependent kinase 2 with inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.

Chain: A (292 residues) CATH domains: 3.30.200.20 1.10.510.10

2r3j

Crystal structure of cyclin-dependent kinase 2 with inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.

Chain: A (283 residues) CATH domains: 3.30.200.20 1.10.510.10

2r3k

Crystal structure of cyclin-dependent kinase 2 with inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.

Chain: A (282 residues) CATH domains: 3.30.200.20 1.10.510.10

2r3l

Crystal structure of cyclin-dependent kinase 2 with inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.

Chain: A (279 residues) CATH domains: 3.30.200.20 1.10.510.10

2r3m

Crystal structure of cyclin-dependent kinase 2 with inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.

Chain: A (283 residues) CATH domains: 3.30.200.20 1.10.510.10

2r3n

Crystal structure of cyclin-dependent kinase 2 with inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.

Chain: A (279 residues) CATH domains: 3.30.200.20 1.10.510.10

2r3o

Crystal structure of cyclin-dependent kinase 2 with inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.

Chain: A (292 residues) CATH domains: 3.30.200.20 1.10.510.10

2r3p

Crystal structure of cyclin-dependent kinase 2 with inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.

Chain: A (292 residues) CATH domains: 3.30.200.20 1.10.510.10

2r3q

Crystal structure of cyclin-dependent kinase 2 with inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.

Chain: A (290 residues) CATH domains: 3.30.200.20 1.10.510.10

2r3r

Crystal structure of cyclin-dependent kinase 2 with inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469.

Chain: A (292 residues) CATH domains: 3.30.200.20 1.10.510.10

2r64

Crystal structure of a 3-aminoindazole compound with cdk2

Source: Homo sapiens. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Chain: A (279 residues) CATH domains: 3.30.200.20 1.10.510.10

2uue

Replace: a strategy for iterative design of cyclin binding groove inhibitors

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic construct.

Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10

2uzb

Crystal structure of human cdk2 complexed with a thiazolidinone inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.

Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10

2uzd

Crystal structure of human cdk2 complexed with a thiazolidinone inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.

Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10

2uze

Crystal structure of human cdk2 complexed with a thiazolidinone inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.

Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10

2uzl

Crystal structure of human cdk2 complexed with a thiazolidinone inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 511693.

Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10

2uzn

Crystal structure of human cdk2 complexed with a thiazolidinone inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: A (279 residues) CATH domains: 3.30.200.20 1.10.510.10

2uzo

Crystal structure of human cdk2 complexed with a thiazolidinone inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: A (290 residues) CATH domains: 3.30.200.20 1.10.510.10

2v0d

Crystal structure of human cdk2 complexed with a thiazolidinone inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: A (292 residues) CATH domains: 3.30.200.20 1.10.510.10

2v22

Replace: a strategy for iterative design of cyclin binding groove inhibitors

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Expressed in: escherichia coli. Expression_system_taxid: 562

Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10

2vta

Identification of n-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1h- pyrazole-3-carboxamide (at7519), a novel cyclin dependent kinase inhibitor using fragment-based x-ray crystallography and structure based drug design.

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (278 residues) CATH domains: 3.30.200.20 1.10.510.10

2vth

Identification of n-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1h- pyrazole-3-carboxamide (at7519), a novel cyclin dependent kinase inhibitor using fragment-based x-ray crystallography and structure based drug design

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (278 residues) CATH domains: 3.30.200.20 1.10.510.10

2vti

Identification of n-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1h- pyrazole-3-carboxamide (at7519), a novel cyclin dependent kinase inhibitor using fragment-based x-ray crystallography and structure based drug design.

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (280 residues) CATH domains: 3.30.200.20 1.10.510.10

2vtj

Identification of n-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1h- pyrazole-3-carboxamide (at7519), a novel cyclin dependent kinase inhibitor using fragment-based x-ray crystallography and structure based drug design

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (276 residues) CATH domains: 3.30.200.20 1.10.510.10

2vtl

Identification of n-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1h- pyrazole-3-carboxamide (at7519), a novel cyclin dependent kinase inhibitor using fragment-based x-ray crystallography and structure based drug design

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (290 residues) CATH domains: 3.30.200.20 1.10.510.10

2vtm

Identification of n-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1h- pyrazole-3-carboxamide (at7519), a novel cyclin dependent kinase inhibitor using fragment-based x-ray crystallography and structure based drug design.

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (290 residues) CATH domains: 3.30.200.20 1.10.510.10

2vtn

Identification of n-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1h- pyrazole-3-carboxamide (at7519), a novel cyclin dependent kinase inhibitor using fragment-based x-ray crystallography and structure based drug design.

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (274 residues) CATH domains: 3.30.200.20 1.10.510.10

2vto

Identification of n-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1h- pyrazole-3-carboxamide (at7519), a novel cyclin dependent kinase inhibitor using fragment-based x-ray crystallography and structure based drug design.

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (283 residues) CATH domains: 3.30.200.20 1.10.510.10

2vtp

Identification of n-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1h- pyrazole-3-carboxamide (at7519), a novel cyclin dependent kinase inhibitor using fragment-based x-ray crystallography and structure based drug design.

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (281 residues) CATH domains: 3.30.200.20 1.10.510.10

2vtq

Identification of n-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1h- pyrazole-3-carboxamide (at7519), a novel cyclin dependent kinase inhibitor using fragment-based x-ray crystallography and structure based drug design.

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (274 residues) CATH domains: 3.30.200.20 1.10.510.10

2vtr

Identification of n-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1h- pyrazole-3-carboxamide (at7519), a novel cyclin dependent kinase inhibitor using fragment-based x-ray crystallography and structure based drug design

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (290 residues) CATH domains: 3.30.200.20 1.10.510.10

2vts

Identification of n-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1h- pyrazole-3-carboxamide (at7519), a novel cyclin dependent kinase inhibitor using fragment-based x-ray crystallography and structure based drug design.

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (282 residues) CATH domains: 3.30.200.20 1.10.510.10

2vtt

Identification of n-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1h- pyrazole-3-carboxamide (at7519), a novel cyclin dependent kinase inhibitor using fragment-based x-ray crystallography and structure based drug design.

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (272 residues) CATH domains: 3.30.200.20 1.10.510.10

2vu3

Identification of n-(4-piperidinyl)-4-(2,6-dichlorobenzoylamino)-1h- pyrazole-3-carboxamide (at7519), a novel cyclin dependent kinase inhibitor using fragment-based x-ray crystallography and structure based drug design.

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (285 residues) CATH domains: 3.30.200.20 1.10.510.10

2vv9

Cdk2 in complex with an imidazole piperazine

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.

Chain: A (280 residues) CATH domains: 3.30.200.20 1.10.510.10

2w05

Structure of cdk2 in complex with an imidazolyl pyrimidine, compound 5b

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.

Chain: A (276 residues) CATH domains: 3.30.200.20 1.10.510.10

2w06

Structure of cdk2 in complex with an imidazolyl pyrimidine, compound 5c

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.

Chain: A (283 residues) CATH domains: 3.30.200.20 1.10.510.10

2w17

Cdk2 in complex with the imidazole pyrimidine amide, compound (s)-8b

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.

Chain: A (279 residues) CATH domains: 3.30.200.20 1.10.510.10

2w1h

Fragment-based discovery of the pyrazol-4-yl urea (at9283), a multi- targeted kinase inhibitor with potent aurora kinase activity

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (283 residues) CATH domains: 3.30.200.20 1.10.510.10

2w96

Crystal structure of cdk4 in complex with a d-type cyclin

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.

Chain: B (267 residues) CATH domains: 3.30.200.20 1.10.510.10

2w99

Crystal structure of cdk4 in complex with a d-type cyclin

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.

Chain: B (291 residues) CATH domains: 3.30.200.20 1.10.510.10

2w9f

Crystal structure of cdk4 in complex with a d-type cyclin

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.

Chain: B (261 residues) CATH domains: 3.30.200.20 1.10.510.10

2w9z

Crystal structure of cdk4 in complex with a d-type cyclin

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.

Chain: B (287 residues) CATH domains: 3.30.200.20 1.10.510.10

2wev

Truncation and optimisation of peptide inhibitors of cdk2, cyclin a through structure guided design

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes.

Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10

2wfy

Truncation and optimisation of peptide inhibitors of cdk2, cyclin a through structure guided design

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes.

Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10

2whb

Truncation and optimisation of peptide inhibitors of cdk2, cyclin a through structure guided design

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes.

Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10

2wih

Structure of cdk2-cyclin a with pha-848125

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high five. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.

Chains: A, C (302 residues) CATH domains: 3.30.200.20 1.10.510.10

2wip

Structure of cdk2-cyclin a complexed with 8-anilino-1-methyl-4,5- dihydro- 1h-pyrazolo[4,3-h] quinazoline-3-carboxylic acid

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high five. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693.

Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10

2wma

Structural and thermodynamic consequences of cyclization of peptide ligands for the recruitment site of cyclin a

Source: Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 511693. Synthetic: yes. Organism_taxid: 9606

Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10

2wmb

Structural and thermodynamic consequences of cyclization of peptide ligands for the recruitment site of cyclin a

Source: Homo sapiens. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 511693. Synthetic: yes. Organism_taxid: 9606

Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10

2wpa

Optimisation of 6,6-dimethyl pyrrolo 3,4-c pyrazoles: identification of pha-793887, a potent cdk inhibitor suitable for intravenous dosing

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high five. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693

Chains: A, C (302 residues) CATH domains: 3.30.200.20 1.10.510.10

2wxv

Structure of cdk2-cyclin a with a pyrazolo(4,3-h) quinazoline-3- carboxamide inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high five. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693

Chains: A, C (302 residues) CATH domains: 3.30.200.20 1.10.510.10

2x1n

Truncation and optimisation of peptide inhibitors of cdk2, cyclin a through structure guided design

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic construct.

Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10

2xmy

Discovery and characterisation of 2-anilino-4-(thiazol-5-yl) pyrimidine transcriptional cdk inhibitors as anticancer agents

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (295 residues) CATH domains: 3.30.200.20 1.10.510.10

2xnb

Discovery and characterisation of 2-anilino-4-(thiazol-5-yl) pyrimidine transcriptional cdk inhibitors as anticancer agents

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (296 residues) CATH domains: 3.30.200.20 1.10.510.10

3bht

Structure of phosphorylated thr160 cdk2/cyclin a in complex with the inhibitor meriolin 3

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562. Bos taurus. Cattle. Organism_taxid: 9913.

Chains: A, C (298 residues) CATH domains: 3.30.200.20 1.10.510.10

3bhu

Structure of phosphorylated thr160 cdk2/cyclin a in complex with the inhibitor meriolin 5

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562. Bos taurus. Cattle. Organism_taxid: 9913.

Chains: A, C (298 residues) CATH domains: 3.30.200.20 1.10.510.10

3bhv

Structure of phosphorylated thr160 cdk2/cyclin a in complex with the inhibitor variolin b

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562. Bos taurus. Cattle. Organism_taxid: 9913.

Chains: A, C (298 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group VAR is 44.12% similar to enzyme product ADP

Het Group VAR is 44.12% similar to enzyme product ADP

3blh

Crystal structure of human cdk9/cyclint1

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk9. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnt1.

Chain: A (292 residues) CATH domains: 3.30.200.20 1.10.510.10

3blq

Crystal structure of human cdk9/cyclint1 in complex with atp

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk9. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnt1.

Chain: A (296 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ATP corresponds to enzyme reactant ATP

Het Group ATP corresponds to enzyme reactant ATP

3blr

Crystal structure of human cdk9/cyclint1 in complex with flavopiridol

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk9. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnt1.

Chain: A (301 residues) CATH domains: 3.30.200.20 1.10.510.10

3ddp

Structure of phosphorylated thr160 cdk2/cyclin a in complex with the inhibitor cr8

Source: Homo sapiens. Human. Gene: cdk2. Expressed in: escherichia coli. Bos taurus. Bovine. Gene: ccna2, ccna.

Chains: A, C (298 residues) CATH domains: 3.30.200.20 1.10.510.10

3ddq

Structure of phosphorylated thr160 cdk2/cyclin a in complex with the inhibitor roscovitine

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Bos taurus. Bovine. Organism_taxid: 9913. Gene: ccna2, ccna.

Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10

3dog

Structure of thr 160 phosphorylated cdk2/cyclin a in complex with the inhibitor n-&-n1

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Bos taurus. Bovine, cow. Organism_taxid: 9913. Gene: ccna2, ccna.

Chains: A, C (298 residues) CATH domains: 3.30.200.20 1.10.510.10

3eid

Cdk2/cyclina complexed with a pyrazolopyridazine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccna2, ccn1, ccna. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, C (292 residues) CATH domains: 3.30.200.20 1.10.510.10

3ej1

Cdk2/cyclina complexed with a pyrazolopyridazine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccna2, ccn1, ccna. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chains: A, C (295 residues) CATH domains: 3.30.200.20 1.10.510.10

3eoc

Cdk2/cyclina complexed with a imidazo triazin-2-amine

Source: Homo sapiens. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Gene: ccna2, ccn1, ccna. Expressed in: escherichia coli.

Chains: A, C (295 residues) CATH domains: 3.30.200.20 1.10.510.10

3ezr

Cdk-2 with indazole inhibitor 17 bound at its active site

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (273 residues) CATH domains: 3.30.200.20 1.10.510.10

3ezv

Cdk-2 with indazole inhibitor 9 bound at its active site

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (277 residues) CATH domains: 3.30.200.20 1.10.510.10

3f5x

Cdk-2-cyclin complex with indazole inhibitor 9 bound at its active site

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccna2, ccn1, ccna. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10

3fz1

Crystal structure of a benzthiophene inhibitor bound to human cyclin- dependent kinase-2 (cdk-2)

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdk2_human. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: A (284 residues) CATH domains: 3.30.200.20 1.10.510.10

3g33

Crystal structure of cdk4/cyclin d3

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnd3, hcg_16683. Expression_system_taxid: 7108

Chains: A, C (291 residues) CATH domains: 3.30.200.20 1.10.510.10

3gbz

Structure of the cmgc cdk kinase from giardia lamblia

Source: Giardia lamblia. Organism_taxid: 184922. Strain: atcc 50803. Gene: gl50803_8037. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (274 residues) CATH domains: 3.30.200.20 1.10.510.10

3gc0

Structure of the cmgc cdk kinase from giardia lamblia in complex with amp

Source: Giardia lamblia. Organism_taxid: 184922. Strain: atcc 50803. Gene: gl50803_8037. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (278 residues) CATH domains: 3.30.200.20 1.10.510.10

3ig7

Novel cdk-5 inhibitors - crystal structure of inhibitor efp with cdk-2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Chain: A (279 residues) CATH domains: 3.30.200.20 1.10.510.10

3igg

Novel cdk-5 inhibitors - crystal structure of inhibitor efq with cdk-2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Chain: A (291 residues) CATH domains: 3.30.200.20 1.10.510.10

3le6

The structure of cyclin dependent kinase 2 (ckd2) with a pyrazolobenzodiazepine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2.

Chain: A (283 residues) CATH domains: 3.30.200.20 1.10.510.10

3lfn

Crystal structure of cdk2 with sar57, an aminoindazole type inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Chain: A (285 residues) CATH domains: 3.30.200.20 1.10.510.10

3lfq

Crystal structure of cdk2 with sar60, an aminoindazole type inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Chain: A (289 residues) CATH domains: 3.30.200.20 1.10.510.10

3lfs

Crystal structure of cdk2 with sar37, an aminoindazole type inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: A (290 residues) CATH domains: 3.30.200.20 1.10.510.10

3lq5

Structure of cdk9/cyclint in complex with s-cr8

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdc2l4, cdk9. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnt1.

Chain: A (308 residues) CATH domains: 3.30.200.20 1.10.510.10

3mi9

Crystal structure of HIV-1 tat complexed with human p-tefb

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdc2l4, cdk9. Expressed in: spodoptera frugiperda. Expression_system_cell_line: bl21 insect cells. K2420). Gene: ccnt1, cyclin t1. Human immunodeficiency virus type 1.

Chain: A (329 residues) CATH domains: 3.30.200.20 1.10.510.10

3mia

Crystal structure of HIV-1 tat complexed with atp-bound human p-tefb

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdc2l4, cdk9. Expressed in: spodoptera frugiperda. Expression_system_cell: insect cells. K2420). Gene: ccnt1, cyclin t1. Human immunodeficiency virus type 1.

Chain: A (325 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ANP is 81.25% similar to enzyme product ADP

Het Group ANP is 81.25% similar to enzyme product ADP

3mtl

Crystal structure of the pctaire1 kinase in complex with indirubin e804

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3my1

Structure of cdk9/cyclint1 in complex with drb

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdc2l4, cdk9. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnt1.

Chain: A (315 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group RFZ is 46.88% similar to enzyme product ADP

Het Group RFZ is 46.88% similar to enzyme product ADP

3my5

Cdk2/cyclina in complex with drb

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562. Bos taurus. Bovine. Organism_taxid: 9913.

Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group RFZ is 46.88% similar to enzyme product ADP

Het Group RFZ is 46.88% similar to enzyme product ADP

3niz

Cryptosporidium parvum cyclin-dependent kinase cgd5_2510 with adp bound.

Source: Cryptosporidium parvum. Organism_taxid: 353152. Strain: iowa ii. Gene: cgd5_2510. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (288 residues) CATH domains: 3.30.200.20 1.10.510.10

3ns9

Crystal structure of cdk2 in complex with inhibitor bs-194

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (289 residues) CATH domains: 3.30.200.20 1.10.510.10

3nup

Cdk6 (monomeric) in complex with inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk6. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Chain: A (252 residues) CATH domains: 3.30.200.20 1.10.510.10

3nux

Cdk6 (monomeric) in complex with inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk6. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Chain: A (261 residues) CATH domains: 3.30.200.20 1.10.510.10

3pj8

Structure of cdk2 in complex with a pyrazolo[4,3-d]pyrimidine bioisostere of roscovitine.

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (288 residues) CATH domains: 3.30.200.20 1.10.510.10

3pxf

Cdk2 in complex with two molecules of 8-anilino-1-naphthalene sulfonate

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (302 residues) CATH domains: 3.30.200.20 1.10.510.10

3pxq

Cdk2 in complex with 3 molecules of 8-anilino-1-naphthalene sulfonate

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (298 residues) CATH domains: 3.30.200.20 1.10.510.10

3pxr

Apo cdk2 crystallized from jeffamine

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3pxy

Cdk2 in complex with inhibitor jws648

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3pxz

Cdk2 ternary complex with jws648 and ans

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (302 residues) CATH domains: 3.30.200.20 1.10.510.10

3py0

Cdk2 in complex with inhibitor su9516

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3py1

Cdk2 ternary complex with su9516 and ans

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (302 residues) CATH domains: 3.30.200.20 1.10.510.10

3qhr

Structure of a pcdk2/cyclina transition-state mimic

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562. Mus musculus. Mouse. Organism_taxid: 10090.

Chains: A, C (298 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ADP corresponds to enzyme product ADP

Het Group ADP corresponds to enzyme product ADP

3qhw

Structure of a pcdk2/cyclina transition-state mimic

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562. Mus musculus. Mouse. Organism_taxid: 10090.

Chains: A, C (298 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ADP corresponds to enzyme product ADP

Het Group ADP corresponds to enzyme product ADP

3ql8

Cdk2 in complex with inhibitor jws-6-260

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3qqf

Cdk2 in complex with inhibitor l1

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3qqg

Cdk2 in complex with inhibitor l2-5

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3qqh

Cdk2 in complex with inhibitor l2-2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3qqj

Cdk2 in complex with inhibitor l2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3qqk

Cdk2 in complex with inhibitor l4

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3qql

Cdk2 in complex with inhibitor l3

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3qrt

Cdk2 in complex with inhibitor nsk-mc2-55

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3qru

Cdk2 in complex with inhibitor nsk-mc1-12

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (295 residues) CATH domains: 3.30.200.20 1.10.510.10

3qtq

Cdk2 in complex with inhibitor rc-1-137

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3qtr

Cdk2 in complex with inhibitor rc-1-148

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (282 residues) CATH domains: 3.30.200.20 1.10.510.10

3qts

Cdk2 in complex with inhibitor rc-2-12

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (282 residues) CATH domains: 3.30.200.20 1.10.510.10

3qtu

Cdk2 in complex with inhibitor rc-2-132

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3qtw

Cdk2 in complex with inhibitor rc-2-13

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3qtx

Cdk2 in complex with inhibitor rc-2-35

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3qtz

Cdk2 in complex with inhibitor rc-2-36

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3qu0

Cdk2 in complex with inhibitor rc-2-38

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3qwj

Cdk2 in complex with inhibitor kvr-1-142

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3qwk

Cdk2 in complex with inhibitor kvr-1-150

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3qx2

Cdk2 in complex with inhibitor kvr-1-190

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3qx4

Cdk2 in complex with inhibitor kvr-1-78

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3qxo

Cdk2 in complex with inhibitor kvr-1-84

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3qxp

Cdk2 in complex with inhibitor rc-3-89

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3qzf

Cdk2 in complex with inhibitor jws-6-52

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3qzg

Cdk2 in complex with inhibitor jws-6-76

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3qzh

Cdk2 in complex with inhibitor kvr-1-124

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3qzi

Cdk2 in complex with inhibitor kvr-1-126

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3r1q

Cdk2 in complex with inhibitor kvr-1-102

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3r1s

Cdk2 in complex with inhibitor kvr-1-127

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3r1y

Cdk2 in complex with inhibitor kvr-1-134

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3r28

Cdk2 in complex with inhibitor kvr-1-140

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3r6x

Cdk2 in complex with inhibitor kvr-1-158

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3r71

Cdk2 in complex with inhibitor kvr-1-162

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3r73

Cdk2 in complex with inhibitor kvr-1-164

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3r7e

Cdk2 in complex with inhibitor kvr-1-67

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3r7i

Cdk2 in complex with inhibitor kvr-1-74

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (282 residues) CATH domains: 3.30.200.20 1.10.510.10

3r7u

Cdk2 in complex with inhibitor kvr-1-75

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (282 residues) CATH domains: 3.30.200.20 1.10.510.10

3r7v

Cdk2 in complex with inhibitor kvr-1-9

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3r7y

Cdk2 in complex with inhibitor kvr-2-88

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3r83

Cdk2 in complex with inhibitor kvr-2-92

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3r8l

Cdk2 in complex with inhibitor l3-4

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3r8m

Cdk2 in complex with inhibitor l3-3

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (286 residues) CATH domains: 3.30.200.20 1.10.510.10

3r8p

Cdk2 in complex with inhibitor nsk-mc1-6

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3r8u

Cdk2 in complex with inhibitor rc-1-132

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3r8v

Cdk2 in complex with inhibitor rc-1-135

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3r8z

Cdk2 in complex with inhibitor rc-1-136

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (290 residues) CATH domains: 3.30.200.20 1.10.510.10

3r9d

Cdk2 in complex with inhibitor rc-2-135

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3r9h

Cdk2 in complex with inhibitor rc-2-142

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3r9n

Cdk2 in complex with inhibitor rc-2-21

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (282 residues) CATH domains: 3.30.200.20 1.10.510.10

3r9o

Cdk2 in complex with inhibitor rc-2-143

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (282 residues) CATH domains: 3.30.200.20 1.10.510.10

3rah

Cdk2 in complex with inhibitor rc-2-22

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (282 residues) CATH domains: 3.30.200.20 1.10.510.10

3rai

Cdk2 in complex with inhibitor kvr-1-160

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3rak

Cdk2 in complex with inhibitor rc-2-32

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (277 residues) CATH domains: 3.30.200.20 1.10.510.10

3ral

Cdk2 in complex with inhibitor rc-2-34

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (277 residues) CATH domains: 3.30.200.20 1.10.510.10

3rgf

Crystal structure of human cdk8/cycc

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnc.

Chain: A (321 residues) CATH domains: 3.30.200.20 1.10.510.10

3rjc

Cdk2 in complex with inhibitor l4-12

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3rk5

Cdk2 in complex with inhibitor rc-2-72

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3rk7

Cdk2 in complex with inhibitor rc-2-71

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3rk9

Cdk2 in complex with inhibitor rc-2-74

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3rkb

Cdk2 in complex with inhibitor rc-2-73

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3rm6

Cdk2 in complex with inhibitor kvr-2-80

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (293 residues) CATH domains: 3.30.200.20 1.10.510.10

3rm7

Cdk2 in complex with inhibitor kvr-1-91

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3rmf

Cdk2 in complex with inhibitor rc-2-33

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (278 residues) CATH domains: 3.30.200.20 1.10.510.10

3rni

Cdk2 in complex with inhibitor rc-3-86

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3roy

Cdk2 in complex with inhibitor kvr-1-154

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3rpo

Cdk2 in complex with inhibitor kvr-1-156

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3rpr

Cdk2 in complex with inhibitor rc-2-49

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (282 residues) CATH domains: 3.30.200.20 1.10.510.10

3rpv

Cdk2 in complex with inhibitor rc-2-88

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3rpy

Cdk2 in complex with inhibitor rc-2-40

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (277 residues) CATH domains: 3.30.200.20 1.10.510.10

3rzb

Cdk2 in complex with inhibitor rc-2-23

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (282 residues) CATH domains: 3.30.200.20 1.10.510.10

3s00

Cdk2 in complex with inhibitor l4-14

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3s0o

Cdk2 in complex with inhibitor rc-1-138

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (293 residues) CATH domains: 3.30.200.20 1.10.510.10

3s1h

Cdk2 in complex with inhibitor rc-2-39

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (277 residues) CATH domains: 3.30.200.20 1.10.510.10

3s2p

Crystal structure of cdk2 with a 2-aminopyrimidine compound

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: A (279 residues) CATH domains: 3.30.200.20 1.10.510.10

3sqq

Cdk2 in complex with inhibitor rc-3-96

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (288 residues) CATH domains: 3.30.200.20 1.10.510.10

3sw4

Crystal structure of the cdk2 in complex with thiazolylpyrimidine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.

Chain: A (281 residues) CATH domains: 3.30.200.20 1.10.510.10

3sw7

Crystal structure of the cdk2 in complex with thiazolylpyrimidine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.

Chain: A (279 residues) CATH domains: 3.30.200.20 1.10.510.10

3ti1

Cdk2 in complex with sunitinib

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3tiy

Cdk2 in complex with nsc 35676

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (293 residues) CATH domains: 3.30.200.20 1.10.510.10

3tiz

Cdk2 in complex with nsc 111848

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (293 residues) CATH domains: 3.30.200.20 1.10.510.10

3tn8

Cdk9/cyclin t in complex with can508

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdc2l4, cdk9. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnt1.

Chain: A (305 residues) CATH domains: 3.30.200.20 1.10.510.10

3tnh

Cdk9/cyclin t in complex with can508

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdc2l4, cdk9. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Gene: ccnt1.

Chain: A (289 residues) CATH domains: 3.30.200.20 1.10.510.10

3tni

Structure of cdk9/cyclin t f241l

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdc2l4, cdk9. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Gene: ccnt1.

Chain: A (298 residues) CATH domains: 3.30.200.20 1.10.510.10

3tnw

Structure of cdk2/cyclin a in complex with can508

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 562. Bos taurus. Bovine. Organism_taxid: 9913.

Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10

3uli

Human cyclin dependent kinase 2 (cdk2) bound to azabenzimidazole derivative

Source: Homo sapiens. Human. Organism_taxid: 9606. Collection: 7108. Gene: cdk2, cdkn2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Chain: A (286 residues) CATH domains: 3.30.200.20 1.10.510.10

3unj

Cdk2 in complex with inhibitor yl1-038-31

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

3unk

Cdk2 in complex with inhibitor yl5-083

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (295 residues) CATH domains: 3.30.200.20 1.10.510.10

3wbl

Crystal structure of cdk2 in complex with pyrazolopyrimidine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.

Chain: A (283 residues) CATH domains: 3.30.200.20 1.10.510.10

3zdu

Crystal structure of the human cdkl3 kinase domain

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Other_details: site-directed mutagenesis

Chain: A (297 residues) CATH domains: 3.30.200.20 1.10.510.10

4aaa

Crystal structure of the human cdkl2 kinase domain

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (295 residues) CATH domains: 3.30.200.20 1.10.510.10

4acm

Cdk2 in complex with 3-amino-6-(4-{[2-(dimethylamino)ethyl]sulfamoyl}- phenyl)-n-pyridin-3-ylpyrazine-2-carboxamide

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: A (278 residues) CATH domains: 3.30.200.20 1.10.510.10

4agu

Crystal structure of the human cdkl1 kinase domain

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: r3 prare2. Other_details: mammalian gene collection

Chains: A, B, C (277 residues) CATH domains: 3.30.200.20 1.10.510.10

4aua

Liganded x-ray crystal structure of cyclin dependent kinase 6 (cdk6)

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Chain: A (256 residues) CATH domains: 3.30.200.20 1.10.510.10

4bbm

Crystal structure of the human cdkl2 kinase domain with bound tcs 2312

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Other_details: site-directed mutagenesis

Chains: A, B (314 residues) CATH domains: 3.30.200.20 1.10.510.10

4bcf

Structure of cdk9 in complex with cyclin t and a 2-amino-4-heteroaryl- pyrimidine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: A (308 residues) CATH domains: 3.30.200.20 1.10.510.10

4bcg

Structure of cdk9 in complex with cyclin t and a 2-amino-4-heteroaryl- pyrimidine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: A (313 residues) CATH domains: 3.30.200.20 1.10.510.10

4bch

Structure of cdk9 in complex with cyclin t and a 2-amino-4-heteroaryl- pyrimidine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: A (309 residues) CATH domains: 3.30.200.20 1.10.510.10

4bci

Structure of cdk9 in complex with cyclin t and a 2-amino-4-heteroaryl- pyrimidine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: A (309 residues) CATH domains: 3.30.200.20 1.10.510.10

4bcj

Structure of cdk9 in complex with cyclin t and a 2-amino-4-heteroaryl- pyrimidine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: A (310 residues) CATH domains: 3.30.200.20 1.10.510.10

4bck

Structure of cdk2 in complex with cyclin a and a 2-amino-4-heteroaryl- pyrimidine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562

Chains: A, C (299 residues) CATH domains: 3.30.200.20 1.10.510.10

4bcm

Structure of cdk2 in complex with cyclin a and a 2-amino-4-heteroaryl- pyrimidine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562

Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10

4bcn

Structure of cdk2 in complex with cyclin a and a 2-amino-4-heteroaryl- pyrimidine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562

Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10

4bco

Structure of cdk2 in complex with cyclin a and a 2-amino-4-heteroaryl- pyrimidine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Bos taurus. Bovine. Organism_taxid: 9913. Expression_system_taxid: 562

Chains: A, C (299 residues) CATH domains: 3.30.200.20 1.10.510.10

4bcp

Structure of cdk2 in complex with cyclin a and a 2-amino-4-heteroaryl- pyrimidine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Expression_system_taxid: 562

Chains: A, C (299 residues) CATH domains: 3.30.200.20 1.10.510.10

4bcq

Structure of cdk2 in complex with cyclin a and a 2-amino-4-heteroaryl- pyrimidine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Bos taurus. Cattle. Organism_taxid: 9913. Expression_system_taxid: 562

Chains: A, C (293 residues) CATH domains: 3.30.200.20 1.10.510.10

4bgh

Crystal structure of cdk2 in complex with pan-cdk inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: A (275 residues) CATH domains: 3.30.200.20 1.10.510.10

4bgq

Crystal structure of the human cdkl5 kinase domain

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Other_details: site-directed mutagenesis

Chain: A (276 residues) CATH domains: 3.30.200.20 1.10.510.10

4bzd

Structure of cdk2 in complex with a benzimidazopyrimidine

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.

Chain: A (277 residues) CATH domains: 3.30.200.20 1.10.510.10

4cfm

Structure-based design of c8-substituted o6-cyclohexylmethoxyguanine cdk1 and 2 inhibitors.

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli b. Expression_system_taxid: 37762.

Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10

4cfn

Structure-based design of c8-substituted o6-cyclohexylmethoxyguanine cdk1 and 2 inhibitors.

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli b. Expression_system_taxid: 37762.

Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10

4cfu

Structure-based design of c8-substituted o6-cyclohexylmethoxyguanine cdk1 and 2 inhibitors.

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli b. Expression_system_taxid: 37762.

Chains: A, C (300 residues) CATH domains: 3.30.200.20 1.10.510.10

4cfv

Structure-based design of c8-substituted o6-cyclohexylmethoxyguanine cdk1 and 2 inhibitors.

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli b. Expression_system_taxid: 37762.

Chains: A, C (301 residues) CATH domains: 3.30.200.20 1.10.510.10

4cfw

Structure-based design of c8-substituted o6-cyclohexylmethoxyguanine cdk1 and 2 inhibitors.

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli b. Expression_system_taxid: 37762.

Chains: A, C (300 residues) CATH domains: 3.30.200.20 1.10.510.10

4cfx

Structure-based design of c8-substituted o6-cyclohexylmethoxyguanine cdk1 and 2 inhibitors.

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli b. Expression_system_taxid: 37762.

Chains: A, C (299 residues) CATH domains: 3.30.200.20 1.10.510.10

4crl

Crystal structure of human cdk8-cyclin c in complex with cortistatin a

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: A (339 residues) CATH domains: 3.30.200.20 1.10.510.10

4cxa

Crystal structure of the human cdk12-cyclin k complex bound to amppnp

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chains: A, C (330 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ANP is 81.25% similar to enzyme product ADP

Het Group ANP is 81.25% similar to enzyme product ADP

4d1x

Cdk2 in complex with luciferin

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (274 residues) CATH domains: 3.30.200.20 1.10.510.10

4d1z

Cdk2 in complex with a luciferin derivate

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (258 residues) CATH domains: 3.30.200.20 1.10.510.10

4ec8

Structure of full length cdk9 in complex with cyclint and drb

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk9, cdc2l4, tak. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnt1. Expression_system_taxid: 7108

Chain: A (326 residues) CATH domains: 3.30.200.20 1.10.510.10

4ec9

Crystal structure of full-length cdk9 in complex with cyclin t

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdc2l4, cdk9, tak. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Gene: ccnt1.

Chain: A (307 residues) CATH domains: 3.30.200.20 1.10.510.10

4ek3

Crystal structure of apo cdk2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.

Chain: A (289 residues) CATH domains: 3.30.200.20 1.10.510.10

4ek4

Crystal structure of the cdk2 in complex with aminopyrazole inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.

Chain: A (288 residues) CATH domains: 3.30.200.20 1.10.510.10

4ek5

Crystal structure of the cdk2 in complex with aminopyrazole inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.

Chain: A (290 residues) CATH domains: 3.30.200.20 1.10.510.10

4ek6

Crystal structure of the cdk2 in complex with aminopyrazole inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.

Chain: A (279 residues) CATH domains: 3.30.200.20 1.10.510.10

4ek8

Crystal structure of the cdk2 in complex with thiazolylpyrimidine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.

Chain: A (282 residues) CATH domains: 3.30.200.20 1.10.510.10

4eoi

Thr 160 phosphorylated cdk2 k89d, q131e - human cyclin a3 complex with the inhibitor ro3306

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccna2, ccn1, ccna. Expression_system_taxid: 562

Chains: A, C (295 residues) CATH domains: 3.30.200.20 1.10.510.10

4eoj

Thr 160 phosphorylated cdk2 h84s, q85m, k89d - human cyclin a3 complex with atp

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccna2, ccn1, ccna. Expression_system_taxid: 562

Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ATP corresponds to enzyme reactant ATP

Het Group ATP corresponds to enzyme reactant ATP

4eok

Thr 160 phosphorylated cdk2 h84s, q85m, k89d - human cyclin a3 complex with the inhibitor nu6102

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccna2, ccn1, ccna. Expression_system_taxid: 562

Chains: A, C (294 residues) CATH domains: 3.30.200.20 1.10.510.10

4eol

Thr 160 phosphorylated cdk2 h84s, q85m, k89d - human cyclin a3 complex with the inhibitor ro3306

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccna2, ccn1, ccna. Expression_system_taxid: 562

Chains: A, C (295 residues) CATH domains: 3.30.200.20 1.10.510.10

4eom

Thr 160 phosphorylated cdk2 h84s, q85m, q131e - human cyclin a3 complex with atp

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccna2, ccn1, ccna. Expression_system_taxid: 562

Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ATP corresponds to enzyme reactant ATP

Het Group ATP corresponds to enzyme reactant ATP

4eon

Thr 160 phosphorylated cdk2 h84s, q85m, q131e - human cyclin a3 complex with the inhibitor ro3306

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccna2, ccn1, ccna. Expression_system_taxid: 562

Chains: A, C (300 residues) CATH domains: 3.30.200.20 1.10.510.10

4eoo

Thr 160 phosphorylated cdk2 q131e - human cyclin a3 complex with atp

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccna2, ccn1, ccna. Expression_system_taxid: 562

Chains: A, C (295 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligand: Het Group ATP corresponds to enzyme reactant ATP

4eop

Thr 160 phosphorylated cdk2 q131e - human cyclin a3 complex with the inhibitor ro3306

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccna2, ccn1, ccna. Expression_system_taxid: 562

Chains: A, C (298 residues) CATH domains: 3.30.200.20 1.10.510.10

4eoq

Thr 160 phosphorylated cdk2 wt - human cyclin a3 complex with atp

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccna2, ccn1, ccna. Expression_system_taxid: 562

Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ATP corresponds to enzyme reactant ATP

Het Group ATP corresponds to enzyme reactant ATP

4eor

Thr 160 phosphorylated cdk2 wt - human cyclin a3 complex with the inhibitor nu6102

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccna2, ccn1, ccna. Expression_system_taxid: 562

Chains: A, C (294 residues) CATH domains: 3.30.200.20 1.10.510.10

4eos

Thr 160 phosphorylated cdk2 wt - human cyclin a3 complex with the inhibitor ro3306

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccna2, ccn1, ccna. Expression_system_taxid: 562

Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10

4erw

Cdk2 in complex with staurosporine

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (293 residues) CATH domains: 3.30.200.20 1.10.510.10

4ez3

Cdk2 in complex with nsc 134199

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

4ez5

Cdk6 (monomeric) in complex with inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk6, cdkn6. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (258 residues) CATH domains: 3.30.200.20 1.10.510.10

4ez7

Cdk2 in complex with staurosporine and 2 molecules of 8-anilino-1- naphthalene sulfonic acid

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (302 residues) CATH domains: 3.30.200.20 1.10.510.10

4f6s

Crystal structure of human cdk8/cycc in complex with compound 7 (1-[3- tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]urea)

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnc.

Chain: A (328 residues) CATH domains: 3.30.200.20 1.10.510.10

4f6u

Crystal structure of human cdk8/cycc in complex with compound 5 (1-[3- tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-[3-(morpholin-4-yl) propyl]urea)

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnc.

Chain: A (334 residues) CATH domains: 3.30.200.20 1.10.510.10

4f6w

Crystal structure of human cdk8/cycc in complex with compound 1 (n-[3- tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-4-[2-({[3-tert-butyl- 1-(4-methylphenyl)-1h-pyrazol-5-yl]carbamoyl}amino)ethyl]piperazine- 1-carboxamide)

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnc.

Chain: A (330 residues) CATH domains: 3.30.200.20 1.10.510.10

4f70

Crystal structure of human cdk8/cycc in complex with compound 4 (1-[3- tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-[2-(morpholin-4-yl) ethyl]urea)

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnc.

Chain: A (327 residues) CATH domains: 3.30.200.20 1.10.510.10

4f7j

Crystal structure of human cdk8/cycc in complex with compound 3 (1-[3- tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-(2-hydroxyethyl) urea)

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnc.

Chain: A (326 residues) CATH domains: 3.30.200.20 1.10.510.10

4f7l

Crystal structure of human cdk8/cycc in complex with compound 2 (tert- butyl [3-({[3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5- yl]carbamoyl}amino)propyl]carbamate)

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnc.

Chain: A (328 residues) CATH domains: 3.30.200.20 1.10.510.10

4f7n

Crystal structure of human cdk8/cycc in complex with compound 11 (1- [3-tert-butyl-1-(4-methylphenyl)-1h-pyrazol-5-yl]-3-(5- hydroxypentyl)urea)

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnc.

Chain: A (334 residues) CATH domains: 3.30.200.20 1.10.510.10

4f7s

Crystal structure of human cdk8/cycc in the dmg-in conformation

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnc.

Chain: A (339 residues) CATH domains: 3.30.200.20 1.10.510.10

4fkg

Crystal structure of the cdk2 in complex with aminopyrazole inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.

Chain: A (287 residues) CATH domains: 3.30.200.20 1.10.510.10

4fki

Crystal structure of the cdk2 in complex with aminopyrazole inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.

Chain: A (288 residues) CATH domains: 3.30.200.20 1.10.510.10

4fkj

Crystal structure of the cdk2 in complex with aminopyrazole inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.

Chain: A (279 residues) CATH domains: 3.30.200.20 1.10.510.10

4fkl

Crystal structure of the cdk2 in complex with thiazolylpyrimidine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.

Chain: A (292 residues) CATH domains: 3.30.200.20 1.10.510.10

4fko

Crystal structure of the cdk2 in complex with thiazolylpyrimidine inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.

Chain: A (292 residues) CATH domains: 3.30.200.20 1.10.510.10

4fkp

Crystal structure of the cdk2 in complex with oxindole inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.

Chain: A (281 residues) CATH domains: 3.30.200.20 1.10.510.10

4fkq

Crystal structure of the cdk2 in complex with oxindole inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.

Chain: A (284 residues) CATH domains: 3.30.200.20 1.10.510.10

4fkr

Crystal structure of the cdk2 in complex with oxindole inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.

Chain: A (283 residues) CATH domains: 3.30.200.20 1.10.510.10

4fks

Crystal structure of the cdk2 in complex with oxindole inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.

Chain: A (276 residues) CATH domains: 3.30.200.20 1.10.510.10

4fkt

Crystal structure of the cdk2 in complex with oxindole inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.

Chain: A (279 residues) CATH domains: 3.30.200.20 1.10.510.10

4fku

Crystal structure of the cdk2 in complex with oxindole inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

4fkv

Crystal structure of the cdk2 in complex with oxindole inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.

Chain: A (283 residues) CATH domains: 3.30.200.20 1.10.510.10

4fkw

Crystal structure of the cdk2 in complex with oxindole inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high-five.

Chain: A (281 residues) CATH domains: 3.30.200.20 1.10.510.10

4fx3

Crystal structure of the cdk2/cyclin a complex with oxindole inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: high-five. Gene: ccn1, ccna, ccna2, cyclin a.

Chains: A, C (298 residues) CATH domains: 3.30.200.20 1.10.510.10

4g6l

Crystal structure of human cdk8/cycc in the dmg-in conformation

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnc.

Chain: A (336 residues) CATH domains: 3.30.200.20 1.10.510.10

4gcj

Cdk2 in complex with inhibitor rc-3-89

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Chain: A (304 residues) CATH domains: 3.30.200.20 1.10.510.10

4i3z

Structure of pcdk2/cyclina bound to adp and 2 magnesium ions

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 511693. Mus musculus. Mouse. Organism_taxid: 10090.

Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligand: Het Group ADP corresponds to enzyme product ADP

4ii5

Structure of pcdk2/cyclina bound to adp and 1 magnesium ion

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 511693. Mus musculus. Mouse. Organism_taxid: 10090.

Chains: A, C (296 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ADP corresponds to enzyme product ADP

Het Group ADP corresponds to enzyme product ADP

4imy

The aff4 scaffold binds human p-tefb adjacent to HIV tat

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk9, cdc2l4, tak. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnt1. Gene: aff4, af5q31, mcef, hspc092. Expressed in: escherichia coli.

Chains: A, C, E (315 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group AMP is 85.19% similar to enzyme product ADP

Het Group AMP is 85.19% similar to enzyme product ADP

4kd1

Cdk2 in complex with dinaciclib

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (298 residues) CATH domains: 3.30.200.20 1.10.510.10

4krc

Crystal structure of pho85-pcl10-atp-gamma-s complex

Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Gene: p7102.18a, pho85, ssg3, ypl031c. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: g2838, pcl10, ygl134w.

Chain: A (297 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group AGS is 93.75% similar to enzyme reactant ATP

Het Group AGS is 93.75% similar to enzyme reactant ATP

4krd

Crystal structure of pho85-pcl10 complex

Source: Saccharomyces cerevisiae. Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Gene: p7102.18a, pho85, ssg3, ypl031c. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: g2838, pcl10, ygl134w.

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

4lyn

Crystal structure of cyclin-dependent kinase 2 (cdk2-wt) complex with (2s)-n-(5-(((5-tert-butyl-1,3-oxazol-2-yl)methyl)sulfanyl)-1,3- thiazol-2-yl)-2-phenylpropanamide

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 511693.

Chain: A (287 residues) CATH domains: 3.30.200.20 1.10.510.10

4nj3

Modulating the interaction between cdk2 and cyclin a with a quinoline- based inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9

Chain: A (282 residues) CATH domains: 3.30.200.20 1.10.510.10

4nst

Crystal structure of human cdk12/cyclin k in complex with adp-aluminum fluoride

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk12, crk7, crkrs, kiaa0904. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnk, cpr4.

Chains: A, C (323 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ADP corresponds to enzyme product ADP

Het Group ADP corresponds to enzyme product ADP

4ogr

Crystal structure of p-tefb complex with aff4 and tat

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk9, cdc2l4, tak. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnt1. Gene: aff4, af5q31, mcef, hspc092. Expressed in: escherichia coli.

Chains: A, E, I (315 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ADN is 70.37% similar to enzyme product ADP

Het Group ADN is 70.37% similar to enzyme product ADP

4or5

Crystal structure of HIV-1 tat complexed with human p-tefb and aff4

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk9, cdc2l4, tak. Gene: ccnt1. HIV-1. Organism_taxid: 11706. Strain: isolate hxb2. Gene: tat.

Chains: A, F (320 residues) CATH domains: 3.30.200.20 1.10.510.10

4rj3

Cdk2 with egfr inhibitor compound 8

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Chain: A (288 residues) CATH domains: 3.30.200.20 1.10.510.10

4tth

Crystal structure of a cdk6/vcyclin complex with inhibitor bound

Source: Saimiriine herpesvirus 2. Sahv-2. Organism_taxid: 10383. Strain: 11. Gene: 72, eclf2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Homo sapiens. Human.

Chain: B (256 residues) CATH domains: 3.30.200.20 1.10.510.10

4un0

Crystal structure of the human cdk12-cyclink complex

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chains: C, D (309 residues) CATH domains: 3.30.200.20 1.10.510.10

4y72

Human cdk1/cyclinb1/cks2 with inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk1, cdc2, cdc28a, cdkn1, p34cdc2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Gene: ccnb1, ccnb. Expressed in: escherichia coli bl21(de3).

Chain: A (292 residues) CATH domains: 3.30.200.20 1.10.510.10

4yc3

Cdk1/cyclinb1/cks2 apo

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk1, cdc2, cdc28a, cdkn1, p34cdc2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Gene: ccnb1, ccnb. Expressed in: escherichia coli bl21(de3).

Chain: A (295 residues) CATH domains: 3.30.200.20 1.10.510.10

4yc6

Cdk1/cks1

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk1, cdc2, cdc28a, cdkn1, p34cdc2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Gene: cks1b, cks1, pnas-143, pnas-16. Expressed in: escherichia coli.

Chains: A, C, E, G (285 residues) CATH domains: 3.30.200.20 1.10.510.10

5a14

Human cdk2 with type ii inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (285 residues) CATH domains: 3.30.200.20 1.10.510.10

5acb

Crystal structure of the human cdk12-cyclink complex

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chains: C, D (325 residues) CATH domains: 3.30.200.20 1.10.510.10

5and

Crystal structure of cdk2 in complex with 2-imidazol-1-yl-1h- benzimidazole processed with the crystaldirect automated mounting and cryo-cooling technology

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21.

Chain: A (273 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group 5JE is 41.38% similar to enzyme product ADP

Het Group 5JE is 41.38% similar to enzyme product ADP

5ane

Crystal structure of cdk2 in complex with 6-methoxy-7h-purine processed with the crystaldirect automated mounting and cryo-cooling technology

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21

Chain: A (294 residues) CATH domains: 3.30.200.20 1.10.510.10

5ang

Crystal structure of cdk2 in complex with 7-hydroxy-4- (morpholinomethyl)chromen-2-one processed with the crystaldirect automated mounting and cryo-cooling technology

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21

Chain: A (268 residues) CATH domains: 3.30.200.20 1.10.510.10

5ani

Crystal structure of cdk2 in complex with 6-chloro-7h-purine processed with the crystaldirect automated mounting and cryo-cooling technology

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21

Chain: A (280 residues) CATH domains: 3.30.200.20 1.10.510.10

5anj

Crystal structure of cdk2 in complex with n-(9h-purin-6-yl)thiophene- 2-carboxamide processed with the crystaldirect automated mounting and cryo-cooling technology

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21

Chain: A (291 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ZXC is 57.14% similar to enzyme product ADP

Het Group ZXC is 57.14% similar to enzyme product ADP

5ank

Crystal structure of cdk2 in complex with 2,4,6-trioxo-1-phenyl- hexahydropyrimidine-5-carboxamide processed with the crystaldirect automated mounting and cryo-cooling technology

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21

Chain: A (273 residues) CATH domains: 3.30.200.20 1.10.510.10

5ano

Crystal structure of cdk2 processed with the crystaldirect automated mounting and cryo-cooling technology

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf21

Chain: A (277 residues) CATH domains: 3.30.200.20 1.10.510.10

5bnj

Cdk8/cycc in complex with 8-{3-chloro-5-[4-(1-methyl-1h-pyrazol-4-yl)- phenyl]-pyridin- 4-yl}-2,8-diaza-spiro[4.5]decan-1-one

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnc. Expression_system_taxid: 7108

Chain: A (343 residues) CATH domains: 3.30.200.20 1.10.510.10

5cei

Crystal structure of cdk8:cyclin c complex with compound 22

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnc. Expression_system_taxid: 7108

Chain: A (345 residues) CATH domains: 3.30.200.20 1.10.510.10

5cyi

Cdk2/cyclin a covalent complex with 6-(cyclohexylmethoxy)-n-(4- (vinylsulfonyl)phenyl)-9h-purin-2-amine (nu6300)

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccna2, ccn1, ccna. Expression_system_taxid: 562

Chains: A, C (299 residues) CATH domains: 3.30.200.20 1.10.510.10

5d1j

Crystal structure of cyclin-dependent kinase 2 (cdk2-wt) complex with n-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl] methyl]thio]-2-thiazolyl]- 4-piperidinecarboxamide (bms-387032)

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 511693.

Chain: A (265 residues) CATH domains: 3.30.200.20 1.10.510.10

5efq

Crystal structure of human cdk13/cyclin k in complex with adp-aluminum fluoride

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk13, cdc2l, cdc2l5, ched, kiaa1791. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnk, cpr4. Expression_system_taxid: 7108

Chains: A, C (322 residues) CATH domains: 3.30.200.20 1.10.510.10

Bound ligands: Het Group ADP corresponds to enzyme product ADP

Het Group ADP corresponds to enzyme product ADP

5fgk

Cdk8-cycc in complex with 8-[3-(3-amino-1h-indazol-6-yl)-5-chloro- pyridine-4-yl]-2,8-diaza-spiro[4.5]decan-1-one

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnc. Expression_system_taxid: 7108

Chain: A (331 residues) CATH domains: 3.30.200.20 1.10.510.10

5fp5

Structure of cyclin-dependent kinase 2 with small-molecule ligand 4- fluorobenzoic acid (at222) in an alternate binding site.

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (264 residues) CATH domains: 3.30.200.20 1.10.510.10

5fp6

Structure of cyclin-dependent kinase 2 with small-molecule ligand 3- (4,7-dichloro-1h-indol-3-yl)prop-2-yn-1-ol (at17833) in an alternate binding site.

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.

Chain: A (278 residues) CATH domains: 3.30.200.20 1.10.510.10

5fwk

Atomic cryoem structure of hsp90-cdc37-cdk4 complex

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: K (210 residues) CATH domain: 1.10.510.10

Bound ligand: Het Group ATP corresponds to enzyme reactant ATP

5fwl

Atomic cryoem structure of hsp90-cdc37-cdk4 complex

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: K (291 residues)

Bound ligand: Het Group ATP corresponds to enzyme reactant ATP

5fwm

Atomic cryoem structure of hsp90-cdc37-cdk4 complex

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: K (291 residues)

Bound ligands: Het Group ATP corresponds to enzyme reactant ATP

Het Group ATP corresponds to enzyme reactant ATP

5fwp

Atomic cryoem structure of hsp90-cdc37-cdk4 complex

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: K (209 residues)

Bound ligands: Het Group ATP corresponds to enzyme reactant ATP

Het Group ATP corresponds to enzyme reactant ATP

5g6v

Crystal structure of the pctaire1 kinase in complex with inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562

Chains: A, B (308 residues) CATH domains: 3.30.200.20 1.10.510.10

5hbe

Cdk8-cycc in complex with 8-[3-chloro-5-(1-methyl-2,2-dioxo-2, 3- dihydro-1h-2l6-benzo[c]isothiazol-5-yl)-pyridin- 4-yl]-1-oxa-3,8- diaza-spiro[4.5]decan-2-one

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnc. Expression_system_taxid: 7108

Chain: A (344 residues) CATH domains: 3.30.200.20 1.10.510.10

5hbh

Cdk8-cycc in complex with 5-{5-chloro-4-[1-(2-methoxy-ethyl)-1,8- diaza-spiro[4.5]dec-8-yl]-pyridin-3-yl}-1-methyl-1,3-dihydro- benzo[c]isothiazole 2,2-dioxide

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnc. Expression_system_taxid: 7108

Chain: A (336 residues) CATH domains: 3.30.200.20 1.10.510.10

5hbj

Cdk8-cycc in complex with 8-[2-amino-3-chloro-5-(1-methyl-1h-indazol- 5-yl)-pyridin-4-yl]-2,8-diaza-spiro[4.5]decan-1-one

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnc. Expression_system_taxid: 7108

Chain: A (342 residues) CATH domains: 3.30.200.20 1.10.510.10

5hnb

Cdk8-cycc in complex with [6-hydroxy-3-(3-methyl-benzyl)-1h-indazol-5- yl]-((s)-3-hydroxy-pyrrolidin-1-yl)-methanone

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnc. Expression_system_taxid: 7108

Chain: A (342 residues) CATH domains: 3.30.200.20 1.10.510.10

5hq0

Ternary complex of human proteins cdk1, cyclin b and cks2, bound to an inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk1, cdc2, cdc28a, cdkn1, p34cdc2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Gene: ccnb1, ccnb. Expressed in: escherichia coli.

Chain: A (292 residues) CATH domains: 3.30.200.20 1.10.510.10

5hvy

Cdk8/cycc in complex with compound 20

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccnc. Expression_system_taxid: 562

Chain: A (335 residues) CATH domains: 3.30.200.20 1.10.510.10

5i5z

Cdk8-cycc in complex with 8-(1-methyl-2,2-dioxo-2,3-dihydro-1h-2l6- benzo[c]isothiazol-5-yl)-[1,6]naphthyridine-2-carboxylic acid methylamide

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnc. Expression_system_taxid: 7108

Chain: A (345 residues) CATH domains: 3.30.200.20 1.10.510.10

5icp

Cdk8-cycc in complex with [(s)-2-(4-chloro-phenyl)-pyrrolidin-1-yl]- (5-methyl-imidazo[5,1-b][1,3,4]thiadiazol-2-yl)-methanone

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnc. Expression_system_taxid: 7108

Chain: A (343 residues) CATH domains: 3.30.200.20 1.10.510.10

5idn

Cdk8-cycc in complex with [(s)-2-(4-chloro-phenyl)-pyrrolidin-1-yl]- (3-methyl-1h-pyrazolo[3,4-b]pyridin-5-yl)-methanone

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnc. Expression_system_taxid: 7108

Chain: A (336 residues) CATH domains: 3.30.200.20 1.10.510.10

5idp

Cdk8-cycc in complex with (3-amino-1h-indazol-5-yl)-[(s)-2-(4-fluoro- phenyl)-piperidin-1-yl]-methanone

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnc. Expression_system_taxid: 7108

Chain: A (342 residues) CATH domains: 3.30.200.20 1.10.510.10

5iev

Crystal structure of bay 1000394 (roniciclib) bound to cdk2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Chain: A (284 residues) CATH domains: 3.30.200.20 1.10.510.10

5iex

Crystal structure of (r,s)-s-{4-[(5-bromo-4-{[(2r,3r)-2-hydroxy-1- methylpropyl]oxy}- pyrimidin-2-yl)amino]phenyl}-s- cyclopropylsulfoximide bound to cdk2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Chain: A (285 residues) CATH domains: 3.30.200.20 1.10.510.10

5iey

Crystal structure of a cdk inhibitor bound to cdk2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Chain: A (286 residues) CATH domains: 3.30.200.20 1.10.510.10

5if1

Crystal structure apo cdk2/cyclin a

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccna2, ccn1, ccna. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chains: A, C (298 residues) CATH domains: 3.30.200.20 1.10.510.10

5jq5

Crystal structure of cdk2 in complex with inhibitor icec0942

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (287 residues) CATH domains: 3.30.200.20 1.10.510.10

5jq8

Crystal structure of cdk2 in complex with inhibitor icec0943

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (278 residues) CATH domains: 3.30.200.20 1.10.510.10

5k4j

Crystal structure of cdk2 in complex with compound 22

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (282 residues) CATH domains: 3.30.200.20 1.10.510.10

5l1z

Tar complex with HIV-1 tat-aff4-p-tefb

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk9, cdc2l4, tak. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnt1. Synthetic: yes. Human immunodeficiency virus type 1 group m

Chain: A (311 residues)

5l2i

The x-ray co-crystal structure of human cdk6 and palbociclib.

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk6, cdkn6. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Chain: A (260 residues) CATH domains: 3.30.200.20 1.10.510.10

5l2s

The x-ray co-crystal structure of human cdk6 and abemaciclib.

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk6, cdkn6. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Chain: A (263 residues) CATH domains: 3.30.200.20 1.10.510.10

5l2t

The x-ray co-crystal structure of human cdk6 and ribociclib.

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk6, cdkn6. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Chain: A (261 residues) CATH domains: 3.30.200.20 1.10.510.10

5l2w

The x-ray co-crystal structure of human cdk2/cycline and dinaciclib.

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccne1, ccne. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (298 residues) CATH domains: 3.30.200.20 1.10.510.10

5lmk

Structure of phopsho-cdk2-cyclin a in complex with an atp-competitive inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccna2, ccn1, ccna. Expression_system_taxid: 562

Chains: A, C (297 residues) CATH domains: 3.30.200.20 1.10.510.10

5lqf

Cdk1/cyclinb1/cks2 in complex with nu6102

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk1, cdc2, cdc28a, cdkn1, p34cdc2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccnb1, ccnb. Gene: cks2. Expression_system_taxid: 562

Chains: A, D (287 residues) CATH domains: 3.30.200.20 1.10.510.10

5mhq

Cct068127 in complex with cdk2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (292 residues)

5nev

Cdk2/cyclin a in complex with compound 73

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: ccna2, ccn1, ccna.

Chains: A, C (296 residues)

5oo0

Cdk2(wt) covalent adduct with d28 at c177

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (288 residues)

5oo1

Cdk2(f80c, c177a) covalent adduct with c37 at f80c

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (278 residues)

5oo3

Cdk2(f80c, c177a) with covalent ligand at f80c

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (286 residues)

5osj

Cdk2(wt) with covalent adduct at c177

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (292 residues)

5osm

Cdk2(f80c, c177a) with covalent adduct at c80

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (292 residues)

5uq1

Crystal structure of human cdk2-spy1 complex

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: spdya, spdy1, spy1. Expression_system_taxid: 562

Chains: A, C (288 residues)

5uq2

Crystal structure of human cdk2-spy1 complex

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: spdya, spdy1, spy1. Expression_system_taxid: 562

Chain: A (296 residues)

5uq3

Crystal structure of human cdk2-spy1-p27 ternary complex

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: spdya, spdy1, spy1. Gene: cdkn1b, kip1. Expression_system_taxid: 562

Chain: A (270 residues)

5xqx

Human cdk8-cycc in complex with compound 4: n-methyl-4-(4-pyridyl)-1h- pyrrole-2-carboxamide

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469. Gene: ccnc. Expression_system_taxid: 10469

Chain: A (340 residues)

5xs2

Cdk8-cycc in complex with compound 17:3-chloro-4-(4-pyridyl)-1h- pyrrole-2-carboxamide

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469. Gene: ccnc. Expression_system_taxid: 10469

Chain: A (366 residues)

6ath

Cdk2/cyclin a/p27-kid-deltac

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccna2, ccn1, ccna. Gene: cdkn1b, kip1.

Chain: A (278 residues)

6b3e

Crystal structure of human cdk12/cyclink in complex with an inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk12, crk7, crkrs, kiaa0904. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnk, cpr4. Expression_system_taxid: 7108

Chains: A, C (310 residues)

6ckx

Structure of cdk12/cyck in complex with a small molecule inhibitor n- (4-(1-methyl-1h-pyrazol-4-yl)phenyl)-n-((1r,4r)-4-(quinazolin-2- ylamino)cyclohexyl)acetamide

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk12, crk7, crkrs, kiaa0904. Expressed in: unidentified baculovirus. Expression_system_taxid: 10469. Gene: ccnk, cpr4. Expression_system_taxid: 10469

Chains: A, C (293 residues)

6cyt

HIV-1 tar loop in complex with tat:aff4:p-tefb

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk9, cdc2l4, tak. Expressed in: spodoptera aff. Frugiperda 2 rz-2014. Expression_system_taxid: 1491790. Gene: ccnt1. Gene: aff4, af5q31, mcef, hspc092. Expressed in: escherichia coli.

Chain: A (319 residues)

6gu2

Cdk1/cyclinb/cks2 in complex with flavopiridol

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk1, cdc2, cdc28a, cdkn1, p34cdc2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Gene: ccnb1, ccnb. Expressed in: escherichia coli bl21(de3).

Chain: A (294 residues)

6gu3

Cdk1/cyclinb/cks2 in complex with azd5438

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk1, cdc2, cdc28a, cdkn1, p34cdc2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Gene: ccnb1, ccnb. Expressed in: escherichia coli bl21(de3).

Chain: A (292 residues)

6gu4

Cdk1/cyclinb/cks2 in complex with cgp74514a

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk1, cdc2, cdc28a, cdkn1, p34cdc2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Gene: ccnb1, ccnb. Expressed in: escherichia coli bl21(de3).

Chain: A (292 residues)

6gu6

Cdk1/cks2 in complex with dinaciclib

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk1, cdc2, cdc28a, cdkn1, p34cdc2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Gene: cks2. Expressed in: escherichia coli.

Chain: A (288 residues)

6gu7

Cdk1/cks2 in complex with azd5438

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk1, cdc2, cdc28a, cdkn1, p34cdc2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9. Gene: cks2. Expressed in: escherichia coli.

Chains: A, C, E, G (284 residues)

6gub

Cdk2/cyclina in complex with flavopiridol

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Bos taurus. Bovine. Organism_taxid: 9913.

Chains: A, C (294 residues)

6guc

Cdk2/cyclina in complex with su9516

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Bos taurus. Cattle. Organism_taxid: 9913.

Chains: A, C (292 residues)

6gue

Cdk2/cyclina in complex with azd5438

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Bos taurus. Cattle. Organism_taxid: 9913.

Chains: A, C (294 residues)

6guf

Cdk2/cyclina in complex with cgp74514a

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Bos taurus. Cattle. Organism_taxid: 9913.

Chains: A, C (296 residues)

6guh

Cdk2 in complex with azd5438

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (284 residues)

6guk

Cdk2 in complex with cgp74514a

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (278 residues)

6gva

Cdk2/cyclin a2 in complex with pyrazolo[4,3-d]pyrimidine inhibitor lgr4455

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccna2, ccn1, ccna. Expression_system_taxid: 562

Chain: A (288 residues)

6gzh

Crystal structure of human cdk9/cyclint1 with a86

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk9, cdc2l4, tak. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnt1. Expression_system_taxid: 7108

Chain: A (310 residues)

6inl

Crystal structure of cdk2 in complex with inhibitor cvt-313

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli-pichia pastoris shuttle vector ppparg4. Expression_system_taxid: 1182032

Chain: A (272 residues)

Bound ligands: Het Group AJR is 40.00% similar to enzyme product ADP

Het Group AJR is 40.00% similar to enzyme product ADP

6jgm

Crystal structure of cdk2 in complex with inhibitor nu-6140

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2. Expressed in: escherichia coli k-12. Expression_system_taxid: 83333.

Chain: A (279 residues)

6o9l

Human holo-pic in the closed state

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: gtf2b, tf2b, tfiib. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: gtf2a2, tf2a2. Gene: tbp, gtf2d1, tf2d, tfiid. Gene: gtf2e1, tf2e1.

Chain: 8 (299 residues)

6oqi

Cdk2 in complex with cpd14 (5-fluoro-4-(4-methyl-5,6,7,8-tetrahydro- 4h-pyrazolo[1,5-a]azepin-3-yl)-n-(5-(4-methylpiperazin-1-yl)pyridin- 2-yl)pyrimidin-2-amine)

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111.

Chain: A (290 residues)

6oql

Cdk6 in complex with cpd13 (r)-5-fluoro-4-(4-methyl-5,6,7,8- tetrahydro-4h-pyrazolo[1,5-a]azepin-3-yl)-n-(5-(4-methylpiperazin-1- yl)pyridin-2-yl)pyrimidin-2-amine

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk6, cdkn6. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: A (263 residues)

6oqo

Cdk6 in complex with cpd24 n-(5-(6-ethyl-2,6-diazaspiro[3.3]heptan-2- yl)pyridin-2-yl)-5-fluoro-4-(4-methyl-5,6,7,8-tetrahydro-4h- pyrazolo[1,5-a]azepin-3-yl)pyrimidin-2-amine

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk6, cdkn6. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: A (269 residues)

6p3w

Crystal structure of the cyclin a-cdk2-orc1 complex

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: ccna2, ccn1, ccna. Expression_system_taxid: 469008

Chains: A, C (298 residues)

6p8e

Crystal structure of cdk4 in complex with cyclind1 and p27

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ccnd1, bcl1, prad1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: cdk4. Gene: cdkn1b, kip1. Expression_system_taxid: 7108

Chain: B (260 residues)

6p8f

Crystal structure of cdk4 in complex with cyclind1 and p27

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ccnd1, bcl1, prad1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: cdk4. Gene: cdkn1b, kip1. Expression_system_taxid: 7108

Chain: B (262 residues)

6p8g

Crystal structure of cdk4 in complex with cyclind1 and p27

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ccnd1, bcl1, prad1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: cdk4. Gene: cdkn1b, kip1. Expression_system_taxid: 7108

Chain: B (259 residues)

6p8h

Crystal structure of cdk4 in complex with cyclind1 and p21

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ccnd1, bcl1, prad1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: cdk4. Gene: cdkn1a, cap20, cdkn1, cip1, mda6, pic1, sdi1, waf1. Expression_system_taxid: 7108

Chain: B (258 residues)

6q3b

Cdk2 in complex with fraglite2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (283 residues)

6q3c

Cdk2 in complex with fraglite1

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (289 residues)

6q3f

Cdk2 in complex with fraglite2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (293 residues)

6q48

Cdk2 in complex with fraglite7

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (280 residues)

6q49

Cdk2 in complex with fraglite6

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (287 residues)

6q4a

Cdk2 in complex with fraglite14

Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (292 residues)

6q4b

Cdk2 in complex with fraglite13

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (291 residues)

6q4c

Cdk2 in complex with fraglite16

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (293 residues)

6q4d

Cdk2 in complex with fraglite31

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (289 residues)

6q4e

Cdk2 in complex with fraglite33

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (284 residues)

6q4f

Cdk2 in complex with fraglite32

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (293 residues)

6q4g

Cdk2 in complex with fraglite37

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (282 residues)

6q4h

Cdk2 in complex with fraglite36

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (291 residues)

Bound ligands: Het Group HGH is 41.18% similar to enzyme product ADP

Het Group HGH is 41.18% similar to enzyme product ADP

6q4i

Cdk2 in complex with fraglite35

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (288 residues)

6q4j

Cdk2 in complex with fraglite34

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (289 residues)

Bound ligands: Het Group HHB is 41.94% similar to enzyme product ADP

Het Group HHB is 41.94% similar to enzyme product ADP

6q4k

Cdk2 in complex with fraglite38

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Chain: A (292 residues)

6qtg

Crystal structure of human cdk8/cycc in complex with bi-1347

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: trichoplusia. Expression_system_taxid: 7110. Gene: ccnc. Expressed in: trichoplusia lectula. Expression_system_taxid: 1558359

Chain: A (329 residues)

6qtj

Crystal structure of human cdk8/cycc in complex with bi 919811

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: ccnc. Expression_system_taxid: 7111

Chain: A (330 residues)

6r3s

Crystal structure of cdk8-cycc in complex with compound 1

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnc. Expression_system_taxid: 7108

Chain: A (346 residues)

6rij

Cdk2/cyclin a2 in complex with open-ring 5-nitrosopyrimidine inhibitor lc436

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccna2, ccn1, ccna. Expression_system_taxid: 562

Chains: A, C (290 residues)

6sg4

Structure of cdk2/cyclin a m246q, s247en

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccna2, ccn1, ccna. Expression_system_taxid: 562

Chains: A, C (262 residues)

6t41

Cdk8/cyclin c in complex with n-(4-chlorobenzyl)isoquinolin-4-amine

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnc. Expression_system_taxid: 7108

Chain: A (346 residues)

6td3

Structure of ddb1 bound to cr8-engaged cdk12-cyclink

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddb1, xap1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: cdk12, crk7, crkrs, kiaa0904. Gene: ccnk, cpr4. Expression_system_taxid: 7111

Chains: B, E, H (333 residues)

6tpa

Cdk8/cyclinc in complex with drug etp-50775

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: insect cell expression vector ptie1. Expression_system_taxid: 266783. Gene: ccnc. Expression_system_taxid: 266783

Chain: A (336 residues)

6twn

Crystal structure of talin1 r7r8 in complex with cdk1 (206-223)

Source: Mus musculus. Mouse. Organism_taxid: 10090. Gene: tln1, tln. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Synthetic: yes. Homo sapiens. Human.

Chains: C, D (17 residues)

6w9e

Crystal structure of human cdk9/cyclint1 in complex with mc180295

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk9, cdc2l4, tak. Expressed in: escherichia coli 'bl21-gold(de3)plyss ag'. Expression_system_taxid: 866768. Gene: ccnt1. Expression_system_taxid: 866768

Chain: A (311 residues)

6xbz

Structure of the human cdk-activating kinase

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mnat1, cap35, mat1, rnf66. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high5. Gene: ccnh. Gene: cdk7, cak, cak1, cdkn7, mo15, stk1.

Chain: J (298 residues)

Bound ligands: Het Group AGS is 93.75% similar to enzyme reactant ATP

Het Group AGS is 93.75% similar to enzyme reactant ATP

6xd3

Structure of the human cak in complex with thz1

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mnat1, cap35, mat1, rnf66. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high5. Gene: ccnh. Gene: cdk7, cak, cak1, cdkn7, mo15, stk1.

Chain: J (298 residues)

6y0a

Crystal structure of cdk8-cycc in complex with bi00690300

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk8. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_taxid: 7111

Chain: A (346 residues)

6yl1

Cdk2(f80c) with covalent adduct tk37 at f80c

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (287 residues)

6yl6

Cdk2(f80c)

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (303 residues)

6ylk

Cdk2(f80c) with covalent adduct tk22 at f80c

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (295 residues)

6z3u

Structure of the cak complex form chaetomium thermophilum

Source: Chaetomium thermophilum (strain dsm 1495 / cbs 144.50 / imi 039719). Organism_taxid: 759272. Gene: ctht_0069020. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ctht_0061570. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chains: B, E (322 residues)

6z45

Cdk9-cyclin-t1 complex bound by compound 24

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk9, cdc2l4, tak. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnt1. Expression_system_taxid: 7108

Chain: A (314 residues)

6z4x

Structure of the cak complex form chaetomium thermophilum bound to atp-gamma-s

Source: Chaetomium thermophilum. Organism_taxid: 209285. Expressed in: escherichia coli. Expression_system_taxid: 562. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_taxid: 562

Chains: B, E (322 residues)

7ack

Cdk2/cyclin a2 in complex with an imidazo[1,2-c]pyrimidin-5-one inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccna2, ccn1, ccna. Expression_system_taxid: 562

Chains: A, C (295 residues)

7b5l

Ubiquitin ligation to f-box protein substrates by scf-rbr e3-e3 super- assembly: nedd8-cul1-rbx1-skp1-skp2-ckshs1-cyclin a-cdk2-p27- ube2l3~ub~arih1. Transition state 1

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cul1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: arih1, ari, mop6, ubch7bp, hussy-27. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: L (284 residues)

7b5o

Cryo-em structure of the human cak bound to icec0942 at 2.5 angstroms resolution

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mnat1, cap35, mat1, rnf66. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Expression_system_cell_line: high5. Gene: ccnh. Gene: cdk7, cak, cak1, cdkn7, mo15, stk1.

Chain: J (297 residues)

7b5q

Cryo-em structure of the human cak bound to icec0942 (phenix-opls3e)

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mnat1, cap35, mat1, rnf66. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: ccnh. Gene: cdk7, cak, cak1, cdkn7, mo15, stk1. Expression_system_taxid: 7111

Chain: J (297 residues)

7b5r

Ubiquitin ligation to f-box protein substrates by scf-rbr e3-e3 super- assembly: cul1-rbx1-skp1-skp2-ckshs1-cyclin a-cdk2-p27

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cul1. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: skp2, fbxl1. Gene: cks1b, cks1, pnas-143, pnas-16. Gene: skp1, emc19, ocp2, skp1a, tceb1l.

Chain: L (284 residues)

7b7s

Cdk2/cyclin a2 in complex with 3h-pyrazolo[4,3-f]quinoline-based derivative hsd1368

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccna2, ccn1, ccna. Expression_system_taxid: 562

Chains: A, C (287 residues)

7e34

Crystal structure of sun1-speedy a-cdk2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: spdya, spdy1, spy1. Gene: sun1, kiaa0810, unc84a.

Chain: A (298 residues)

7kjs

Crystal structure of cdk2/cyclin e in complex with pf-06873600

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: ccne1, ccne. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Chain: A (297 residues)

7kpv

Structure of kinase and central lobes of yeast ckm

Source: Saccharomyces cerevisiae (strain atcc 204508 / s288c). Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. Strain: atcc 204508 / s288c

Chain: A (357 residues)

7kpx

Structure of the yeast ckm

Source: Saccharomyces cerevisiae (strain atcc 204508 / s288c). Baker's yeast. Organism_taxid: 559292. Strain: atcc 204508 / s288c. 559292. Strain: atcc 204508 / s288c

Chain: A (357 residues)

7m2f

Cdk2 with compound 14 inhibitor with carboxylate

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9

Chain: A (281 residues)

7mkx

Crystal structure analysis of human cdk2 and ccna2 complex

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccna2, ccn1, ccna. Expression_system_taxid: 562

Chains: A, C (297 residues)

7nj0

Cryoem structure of the human separase-cdk1-cyclin b1-cks1 complex

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pttg1, eap1, pttg, tutr1, espl1, esp1, kiaa0165. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: cdk1, cdc2, cdc28a, cdkn1, p34cdc2. Gene: ccnb1, ccnb. Gene: cks1b, cks1, pnas-143, pnas-16.

Chain: B (290 residues)

7nvq

Aerosol-soaked human cdk2 crystals with staurosporine

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (287 residues)

7nvr

Human mediator with RNA polymerase ii pre-initiation complex

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ercc2, xpd, xpdc. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: gtf2h1, btf2. Gene: gtf2h4. Gene: mnat1, cap35, mat1, rnf66.

Chain: 8 (298 residues)

7nwk

Crystal structure of cdk9-cyclin t1 bound by compound 6

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk9, cdc2l4, tak. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnt1. Expression_system_taxid: 7108

Chain: A (298 residues)

7nxj

Crystal structure of human cdk13/cyclin k in complex with the inhibitor thz531

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk13, cdc2l, cdc2l5, ched, kiaa1791. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnk, cpr4. Expression_system_taxid: 7108

Chains: A, C (325 residues)

7nxk

Crystal structure of human cdk12/cyclin k in complex with the inhibitor bsj-01-175

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk12, crk7, crkrs, kiaa0904. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnk, cpr4. Expression_system_taxid: 7108

Chains: A, C (322 residues)

7qhl

Crystal structure of cyclin-dependent kinase 2/cyclin a in complex with 3,5,7-substituted pyrazolo[4,3-d]pyrimidine inhibitor 24

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: ccna2, ccn1, ccna. Expression_system_taxid: 469008

Chains: A, C (285 residues)

7ra5

Cdk2 in complex with compound 4

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (278 residues)

7rwe

Crystal structure of cdk2 liganded with compound gphr787

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (254 residues)

7rwf

Crystal structure of cdk2 in complex with tw8672

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (299 residues)

7rxo

Crystal structure of cdk2 liganded with compound wn333

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (266 residues)

7s4t

Crystal structure of cdk2 liganded with compound ef2252

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (293 residues)

7s7a

Crystal structure of cdk2 liganded with compound ef3019

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (278 residues)

7s84

Crystal structure of cdk2 liganded with compound tw8972

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (282 residues)

7s85

Crystal structure of cdk2 liganded with compound wn316

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (281 residues)

7s9x

Crystal structure of cdk2 liganded with compound wn378

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (269 residues)

7sa0

Crystal structure of cdk2 liganded with compound ef4195

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (281 residues)

7sj3

Structure of cdk4-cyclin d3 bound to abemaciclib

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk4. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnd3. Expression_system_taxid: 7108

Chain: A (275 residues)

7ug1

Cdk2 liganded with para chloro ans

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (290 residues)

7ukz

Cdk11 in complex with small molecule inhibitor ots964

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk11b, cdc2l1, cdk11, pitslrea, pk58. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Chains: A, B, C, D, E, F (296 residues)

7uxi

Structure of cdk2 in complex with fp19711, a helicon polypeptide

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic construct. Organism_taxid: 32630

Chain: A (280 residues)

7uxk

Structure of cdk2 in complex with fp24322, a helicon polypeptide

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic construct. Organism_taxid: 32630

Chain: A (246 residues)

7vdu

The structure of cyclin-dependent kinase 2 (cdk2) in complex with compound 1

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (291 residues)

7xqk

The crystal structure of cdk3 and cycline1 complex from biortus.

Source: Schistosoma japonicum, homo sapiens. Blood fluke, human. Organism_taxid: 6182, 9606. Gene: cdk3, cdkn3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Homo sapiens. Human. Organism_taxid: 9606.

Chain: A (286 residues)

7zpc

Cdk2 in complex 9k-dos

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chain: A (291 residues)

8b54

Cdk2/cyclin a2 in complex with pyrazolo[4,3-d]pyrimidine inhibitor lgr6768

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: ccna2, ccn1, ccna. Expression_system_taxid: 469008

Chains: A, C (292 residues)

8bu1

Structure of ddb1 bound to ds17-engaged cdk12-cyclin k

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddb1, xap1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: cdk12, crk7, crkrs, kiaa0904. Gene: ccnk, cpr4. Expression_system_taxid: 7111

Chains: B, E, H (330 residues)

8bu2

Structure of ddb1 bound to ds18-engaged cdk12-cyclin k

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddb1, xap1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: cdk12, crk7, crkrs, kiaa0904. Gene: ccnk, cpr4. Expression_system_taxid: 7111

Chains: B, E, H (327 residues)

8bu3

Structure of ddb1 bound to ds19-engaged cdk12-cyclin k

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddb1, xap1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: cdk12, crk7, crkrs, kiaa0904. Gene: ccnk, cpr4. Expression_system_taxid: 7111

Chains: B, E, H (326 residues)

8bu4

Structure of ddb1 bound to ds22-engaged cdk12-cyclin k

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddb1, xap1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: cdk12, crk7, crkrs, kiaa0904. Gene: ccnk, cpr4. Expression_system_taxid: 7111

Chains: B, E, H (329 residues)

8bu5

Structure of ddb1 bound to sr-4835-engaged cdk12-cyclin k

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddb1, xap1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: cdk12, crk7, crkrs, kiaa0904. Gene: ccnk, cpr4. Expression_system_taxid: 7111

Chains: B, E, H (332 residues)

8bu6

Structure of ddb1 bound to ds55-engaged cdk12-cyclin k

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddb1, xap1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: cdk12, crk7, crkrs, kiaa0904. Gene: ccnk, cpr4. Expression_system_taxid: 7111

Chains: H, E, B (324 residues)

8bu7

Structure of ddb1 bound to 21195-engaged cdk12-cyclin k

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddb1, xap1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: cdk12, crk7, crkrs, kiaa0904. Gene: ccnk, cpr4. Expression_system_taxid: 7111

Chains: B, E, H (329 residues)

8bu9

Structure of ddb1 bound to roscovitine-engaged cdk12-cyclin k

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddb1, xap1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: cdk12, crk7, crkrs, kiaa0904. Gene: ccnk, cpr4. Expression_system_taxid: 7111

Chains: B, E, H (325 residues)

8bua

Structure of ddb1 bound to 919278-engaged cdk12-cyclin k

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddb1, xap1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: cdk12, crk7, crkrs, kiaa0904. Gene: ccnk, cpr4. Expression_system_taxid: 7111

Chains: B, E, H (325 residues)

8bub

Structure of ddb1 bound to dcemm4-engaged cdk12-cyclin k

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddb1, xap1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: cdk12, crk7, crkrs, kiaa0904. Gene: ccnk, cpr4. Expression_system_taxid: 7111

Chains: B, E, H (327 residues)

8buc

Structure of ddb1 bound to dcemm3-engaged cdk12-cyclin k

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddb1, xap1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: cdk12, crk7, crkrs, kiaa0904. Gene: ccnk, cpr4. Expression_system_taxid: 7111

Chains: B, E, H (327 residues)

8bud

Structure of ddb1 bound to z7-engaged cdk12-cyclin k

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddb1, xap1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: cdk12, crk7, crkrs, kiaa0904. Gene: ccnk, cpr4. Expression_system_taxid: 7111

Chains: B, E, H (329 residues)

8bue

Structure of ddb1 bound to z11-engaged cdk12-cyclin k

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddb1, xap1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: cdk12, crk7, crkrs, kiaa0904. Gene: ccnk, cpr4. Expression_system_taxid: 7111

Chains: B, E, H (329 residues)

8buf

Structure of ddb1 bound to z12-engaged cdk12-cyclin k

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddb1, xap1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: cdk12, crk7, crkrs, kiaa0904. Gene: ccnk, cpr4. Expression_system_taxid: 7111

Chains: B, E, H (319 residues)

8bug

Structure of ddb1 bound to hq461-engaged cdk12-cyclin k

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddb1, xap1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: cdk12, crk7, crkrs, kiaa0904. Gene: ccnk, cpr4. Expression_system_taxid: 7111

Chains: B, E, H (327 residues)

8buh

Structure of ddb1 bound to wx3-engaged cdk12-cyclin k

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddb1, xap1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: cdk12, crk7, crkrs, kiaa0904. Gene: ccnk, cpr4. Expression_system_taxid: 7111

Chains: B, E, H (325 residues)

8bui

Structure of ddb1 bound to drf-053-engaged cdk12-cyclin k

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddb1, xap1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: cdk12, crk7, crkrs, kiaa0904. Gene: ccnk, cpr4. Expression_system_taxid: 7111

Chains: B, E, H (327 residues)

8buj

Structure of ddb1 bound to ds06-engaged cdk12-cyclin k

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddb1, xap1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: cdk12, crk7, crkrs, kiaa0904. Gene: ccnk, cpr4. Expression_system_taxid: 7111

Chains: B, E, H (327 residues)

8buk

Structure of ddb1 bound to ds08-engaged cdk12-cyclin k

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddb1, xap1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: cdk12, crk7, crkrs, kiaa0904. Gene: ccnk, cpr4. Expression_system_taxid: 7111

Chains: B, E, H (326 residues)

8bul

Structure of ddb1 bound to ds11-engaged cdk12-cyclin k

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddb1, xap1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: cdk12, crk7, crkrs, kiaa0904. Gene: ccnk, cpr4. Expression_system_taxid: 7111

Chains: B, E, H (325 residues)

8bum

Structure of ddb1 bound to ds15-engaged cdk12-cyclin k

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddb1, xap1, ddb1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: cdk12, crk7, crkrs, kiaa0904. Gene: ccnk, cpr4. Expression_system_taxid: 7111

Chains: B, E, H (326 residues)

8bun

Structure of ddb1 bound to ds16-engaged cdk12-cyclin k

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddb1, xap1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: cdk12, crk7, crkrs, kiaa0904. Gene: ccnk, cpr4. Expression_system_taxid: 7111

Chains: B, E, H (327 residues)

8buo

Structure of ddb1 bound to ds24-engaged cdk12-cyclin k

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddb1, ddb1, xap1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: cdk12, crk7, crkrs, kiaa0904. Gene: ccnk, cpr4. Expression_system_taxid: 7111

Chains: B, E, H (326 residues)

8bup

Structure of ddb1 bound to ds30-engaged cdk12-cyclin k

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddb1, xap1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: cdk12, crk7, crkrs, kiaa0904. Gene: ccnk, cpr4. Expression_system_taxid: 7111

Chains: B, E, H (313 residues)

8buq

Structure of ddb1 bound to ds43-engaged cdk12-cyclin k

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddb1, xap1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: cdk12, crk7, crkrs, kiaa0904. Gene: ccnk, cpr4. Expression_system_taxid: 7111

Chains: B, E, H (321 residues)

8bur

Structure of ddb1 bound to ds50-engaged cdk12-cyclin k

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddb1, xap1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: cdk12, crk7, crkrs, kiaa0904. Gene: ccnk, cpr4. Expression_system_taxid: 7111

Chains: E, B, H (326 residues)

8bus

Structure of ddb1 bound to ds59-engaged cdk12-cyclin k

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddb1, xap1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: cdk12, crk7, crkrs, kiaa0904. Gene: ccnk, cpr4. Expression_system_taxid: 7111

Chains: E, B, H (329 residues)

8but

Structure of ddb1 bound to ds61-engaged cdk12-cyclin k

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddb1, xap1. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: cdk12, crk7, crkrs, kiaa0904. Gene: ccnk, cpr4. Expression_system_taxid: 7111

Chains: B, E, H (325 residues)

8bya

Cryo-em structure of skp1-skp2-cks1-cdk2-cyclina-p27kip1 complex

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: plyss. Gene: ccna2, ccn1, ccna. Gene: p27 kip1.

Chain: A (277 residues)

8bzo

Cryo-em structure of cdk2-cyclina in complex with p27 from the scfskp2 e3 ligase complex

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: plyss. Gene: ccna2, ccn1, ccna. Gene: p27 kip1.

Chain: A (284 residues)

8cie

Crystal structure of the human cdkl5 kinase domain with compound yl- 354

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdkl5, stk9. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Chain: A (280 residues)

8cur

Crystal structure of cdk2 in complex with cyclin a inhibitor 6-[(e)-2- (4-chlorophenyl)ethenyl]-2-{[(2r)-3-(4-hydroxyphenyl)-1-methoxy-1- oxopropan-2-yl]carbamoyl}quinoline-4-carboxylic acid

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (274 residues)

8erd

Cyclin-free cdk2 in complex with cpd17

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Chain: A (290 residues)

8ern

Cyclin-free cdk2 in complex with cpd21

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Chain: A (288 residues)

8fow

Ternary complex of cdk2 with small molecule ligands tw8672 and dinaciclib

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (275 residues)

8fp0

Ternary complex of cdk2 with small molecule ligands tw8672 and roscovitine

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (274 residues)

8fp5

Cdk2 liganded with atp and mg2+

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562.

Chain: A (288 residues)

Bound ligands: Het Group ATP corresponds to enzyme reactant ATP

Het Group ATP corresponds to enzyme reactant ATP

8h4r

The crystal structure of cdk3 and cycline1 complex with dinaciclib from biortus

Source: Schistosoma japonicum, homo sapiens. Blood fluke, human. Organism_taxid: 6182, 9606. Gene: cdk3, cdkn3. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Homo sapiens. Human. Organism_taxid: 9606.

Chain: A (287 residues)

8h6p

Complex structure of cdk2/cyclin e1 and a potent, selective macrocyclic inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccne1, ccne. Expression_system_taxid: 562

Chain: A (298 residues)

8h6t

Complex structure of cdk2/cyclin e1 and a potent, selective small molecule inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccne1, ccne. Expression_system_taxid: 562

Chain: A (298 residues)

8i0l

Structure of cdk9/cyclin t1 in complex with inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk9, cdc2l4, tak. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnt1. Expression_system_taxid: 7108

Chain: A (308 residues)

8i0m

Structure of cdk6 in complex with inhibitor

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk6, cdkn6. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108

Chain: A (260 residues)

8k5r

Cdk9/cyclin t1 in complex with kb-0742

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk9. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnt1. Expression_system_taxid: 7108

Chain: A (306 residues)

8or0

Cand1-cul1-rbx1-skp1-skp2-cks1-cdk2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cul1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: rbx1, rnf75, roc1. Gene: cand1, kiaa0829, tip120, tip120a. Expressed in: escherichia coli bl21(de3).

Chain: H (85 residues)

8or4

Partially dissociated cand1-cul1-rbx1-skp1-skp2-cks1-cdk2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cul1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: rbx1, rnf75, roc1. Gene: cand1, kiaa0829, tip120, tip120a. Expressed in: escherichia coli bl21(de3).

Chain: H (49 residues)

8orm

Cryo-em structure of cak-thz1

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mnat1, cap35, mat1, rnf66. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: ccnh. Gene: cdk7, cak, cak1, cdkn7, mo15, stk1. Expression_system_taxid: 7111

Chain: J (288 residues)

8oy2

Human cyclin-dependent kinase 2 in complex with inhibitor hb-29260

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562

Chain: A (274 residues)

8p4z

Crystal structure of the human cdk7 kinase domain in complex with ldc4297

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk7, cak, cak1, cdkn7, mo15, stk1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: expisf9

Chains: A, B (272 residues)

8p6v

Cryo-em structure of cak in complex with inhibitor icec0942

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mnat1, cap35, mat1, rnf66. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: ccnh. Gene: cdk7, cak, cak1, cdkn7, mo15, stk1. Expression_system_taxid: 7111

Chain: J (286 residues)

8p6w

Cryo-em structure of cak in complex with inhibitor bs-181

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mnat1, cap35, mat1, rnf66. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: ccnh. Gene: cdk7, cak, cak1, cdkn7, mo15, stk1. Expression_system_taxid: 7111

Chain: J (286 residues)

8p6x

Cryo-em structure of cak in complex with inhibitor bs-194

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mnat1, cap35, mat1, rnf66. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: ccnh. Gene: cdk7, cak, cak1, cdkn7, mo15, stk1. Expression_system_taxid: 7111

Chain: J (287 residues)

8p6y

Cryo-em structure of cak in complex with nucleotide analogue atpgs

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mnat1, cap35, mat1, rnf66. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: ccnh. Gene: cdk7, cak, cak1, cdkn7, mo15, stk1. Expression_system_taxid: 7111

Chain: J (286 residues)

8p6z

Cryo-em structure of cak in complex with inhibitor icec0510-r

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mnat1, cap35, mat1, rnf66. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: ccnh. Gene: cdk7, cak, cak1, cdkn7, mo15, stk1. Expression_system_taxid: 7111

Chain: J (286 residues)

8p70

Cryo-em structure of cak in complex with inhibitor icec0510-s

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mnat1, cap35, mat1, rnf66. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: ccnh. Gene: cdk7, cak, cak1, cdkn7, mo15, stk1. Expression_system_taxid: 7111

Chain: J (286 residues)

8p71

Cryo-em structure of cak in complex with inhibitor icec0574

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mnat1, cap35, mat1, rnf66. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: ccnh. Gene: cdk7, cak, cak1, cdkn7, mo15, stk1. Expression_system_taxid: 7111

Chain: J (286 residues)

8p72

Cryo-em structure of cak in complex with inhibitor icec0768

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mnat1, cap35, mat1, rnf66. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: ccnh. Gene: cdk7, cak, cak1, cdkn7, mo15, stk1. Expression_system_taxid: 7111

Chain: J (286 residues)

8p73

Cryo-em structure of cak in complex with inhibitor icec0829

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mnat1, cap35, mat1, rnf66. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: ccnh. Gene: cdk7, cak, cak1, cdkn7, mo15, stk1. Expression_system_taxid: 7111

Chain: J (286 residues)

8p74

Cryo-em structure of cak in complex with inhibitor icec0880 (ring-up conformation)

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mnat1, cap35, mat1, rnf66. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: ccnh. Gene: cdk7, cak, cak1, cdkn7, mo15, stk1. Expression_system_taxid: 7111

Chain: J (286 residues)

8p75

Cryo-em structure of cak in complex with inhibitor icec0880 (ring-down conformation)

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mnat1, cap35, mat1, rnf66. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: ccnh. Gene: cdk7, cak, cak1, cdkn7, mo15, stk1. Expression_system_taxid: 7111

Chain: J (286 residues)

8p76

Cryo-em structure of cak in complex with inhibitor icec0914

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mnat1, cap35, mat1, rnf66. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: ccnh. Gene: cdk7, cak, cak1, cdkn7, mo15, stk1. Expression_system_taxid: 7111

Chain: J (286 residues)

8p77

Cryo-em structure of cak in complex with inhibitor icec0943

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mnat1, cap35, mat1, rnf66. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: ccnh. Gene: cdk7, cak, cak1, cdkn7, mo15, stk1. Expression_system_taxid: 7111

Chain: J (286 residues)

8p78

Cryo-em structure of cak in complex with inhibitor dinaciclib

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mnat1, cap35, mat1, rnf66. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: ccnh. Gene: cdk7, cak, cak1, cdkn7, mo15, stk1. Expression_system_taxid: 7111

Chain: J (286 residues)

8p79

Cryo-em structure of cak with averaged inhibitor density

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mnat1, cap35, mat1, rnf66. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: ccnh. Gene: cdk7, cak, cak1, cdkn7, mo15, stk1. Expression_system_taxid: 7111

Chain: J (286 residues)

8p7l

Cryo-em structure of cdk7 subunit of cak in complex with inhibitor ldc4297

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mnat1, cap35, mat1, rnf66. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: cdk7, cak, cak1, cdkn7, mo15, stk1. Expression_system_taxid: 7111

Chain: J (289 residues)

8p81

Crystal structure of human cdk12/cyclin k in complex with inhibitor sr-4835

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk12, crk7, crkrs, kiaa0904. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnk, cpr4. Expression_system_taxid: 7108

Chain: A (320 residues)

8plz

Cryo-em structure of cak in complex with inhibitor ct7030

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mnat1, cap35, mat1, rnf66. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: ccnh. Gene: cdk7, cak, cak1, cdkn7, mo15, stk1. Expression_system_taxid: 7111

Chain: J (286 residues)

8pyr

Crystal structure of the dual t-loop phosphorylated cdk7/cych/mat1 complex

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk7, cak, cak1, cdkn7, mo15, stk1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: ccnh. Gene: mnat1, cap35, mat1, rnf66. Lama glama.

Chains: A, E (266 residues)

8r99

A soakable crystal form of human cdk7 in complex with amp-pnp

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk7. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chain: A (283 residues)

Bound ligands: Het Group ANP is 81.25% similar to enzyme product ADP

Het Group ANP is 81.25% similar to enzyme product ADP

8r9a

A soakable crystal form of human cdk7 in complex with amp-pnp

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk7. Expressed in: spodoptera. Expression_system_taxid: 7106.

Chain: A (285 residues)

8r9b

A soakable crystal form of human cdk7 in complex with amp-pnp

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk7. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chains: A, B, C, D (301 residues)

Bound ligands: Het Group ANP is 81.25% similar to enzyme product ADP

Het Group ANP is 81.25% similar to enzyme product ADP

8r9o

A soakable crystal form of human cdk7 in complex with amp-pnp

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk7. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chains: A, B (276 residues)

8r9s

A soakable crystal form of human cdk7 in complex with amp-pnp

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk7. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chains: A, B (289 residues)

8r9u

A soakable crystal form of human cdk7 in complex with amp-pnp

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk7. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Chains: A, B (282 residues)

8roz

Cryo-em structure of cdk2-cyclin a in complex with cdc25a

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: star. Bos taurus. Cattle.

Chain: A (298 residues)

8ru8

A crystal form of a human cdk2-cdk7 chimera

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21. Expression_system_taxid: 511693

Chain: A (275 residues)

8s0t

Cryo-em structure of cak in complex with sy-5609

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mnat1, cap35, mat1, rnf66. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: ccnh. Gene: cdk7, cak, cak1, cdkn7, mo15, stk1. Expression_system_taxid: 7111

Chain: J (291 residues)

8tq2

Structure of the kinase lobe of human cdk8 kinase module

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: med12. Expressed in: baculovirus expression vector pfastbac1-hm. Expression_system_taxid: 274590. Gene: med13, arc250, kiaa0593, thrap1, trap240. Gene: cdk8. Gene: ccnc.

Chain: A (313 residues)

8tqc

Structure of the human cdk8 kinase module

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: med12. Expressed in: baculovirus expression vector pfastbac1-hm. Expression_system_taxid: 274590. Gene: med13, arc250, kiaa0593, thrap1, trap240. Gene: cdk8. Gene: ccnc.

Chain: A (313 residues)

8tqw

Structure of human transcriptional mediator complex

Source: Homo sapiens. Human. Organism_taxid: 9606. Organism_taxid: 9606

Chain: a (313 residues)

8u2o

Crystal structure of cdk-related protein kinase 6 (pk6) from plasmodium falciparum in complex with inhibitor tcmdc-123995

Source: Plasmodium falciparum 3d7. Organism_taxid: 36329. Gene: pf3d7_1337100. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.

Chains: A, B (289 residues)

8uv0

Discovery of (4-pyrazolyl)-2-aminopyrimidines as potent and selective inhibitors of cyclin-dependent kinase 2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: r3

Chain: A (279 residues)

9esj

Cdk2-cyclin a in complex with fraglite 31

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Bos taurus. Cattle. Organism_taxid: 9913.

Chains: A, C (300 residues)

9esk

Cdk2-cyclin a in complex with fraglite 30

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Bos taurus. Cattle. Organism_taxid: 9913.

Chains: A, C (302 residues)

9esl

Cdk2-cyclin a in complex with fraglite 29

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Bos taurus. Cattle. Organism_taxid: 9913.

Chains: A, C (301 residues)

9esn

Cdk2-cyclin a in complex with fraglite 28

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Bos taurus. Cattle. Organism_taxid: 9913.

Chains: A, C (298 residues)

9eso

Cdk2-cyclin a in complex with fraglite 27

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Bos taurus. Cattle. Organism_taxid: 9913.

Chains: A, C (302 residues)

9esp

Cdk2-cyclin a in complex with fraglite 26

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Bos taurus. Cattle. Organism_taxid: 9913.

Chains: A, C (293 residues)

9esq

Cdk2-cyclin a in complex with fraglite 24

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Bos taurus. Cattle. Organism_taxid: 9913.

Chains: A, C (300 residues)

9esr

Cdk2-cyclin a in complex with fraglite 23

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Bos taurus. Cattle. Organism_taxid: 9913.

Chains: A, C (300 residues)

9ess

Cdk2-cyclin a in complex with fraglite 22

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Bos taurus. Cattle. Organism_taxid: 9913.

Chains: A, C (302 residues)

9esu

Cdk2-cyclin a in complex with fraglite 20

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Bos taurus. Cattle. Organism_taxid: 9913.

Chains: A, C (302 residues)

9esv

Cdk2-cyclin a in complex with fraglite 19

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Bos taurus. Cattle. Organism_taxid: 9913.

Chains: A, C (302 residues)

9esw

Cdk2-cyclin a in complex with fraglite 18

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Bos taurus. Cattle. Organism_taxid: 9913.

Chains: A, C (298 residues)

9esy

Cdk2-cyclin a in complex with fraglite 16

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Bos taurus. Cattle. Organism_taxid: 9913.

Chains: A, C (299 residues)

9esz

Cdk2-cyclin a in complex with fraglite 14

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Bos taurus. Cattle. Organism_taxid: 9913.

Chains: A, C (296 residues)

9et0

Cdk2-cyclin a in complex with fraglite 13

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Bos taurus. Cattle. Organism_taxid: 9913.

Chains: A, C (302 residues)

9et1

Cdk2-cyclin a in complex with fraglite 12

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Bos taurus. Cattle. Organism_taxid: 9913.

Chains: A, C (302 residues)

9et2

Cdk2-cyclin a in complex with fraglite 11

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Bos taurus. Cattle. Organism_taxid: 9913.

Chains: A, C (302 residues)

9et3

Cdk2-cyclin a in complex with fraglite 10

Source: Bos taurus. Cattle. Organism_taxid: 9913. Gene: ccna2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Homo sapiens. Human. Organism_taxid: 9606.

Chains: A, C (295 residues)

9et5

Cdk2-cyclin a in complex with fraglite 8

Source: Bos taurus. Cattle. Organism_taxid: 9913. Gene: ccna2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Homo sapiens. Human. Organism_taxid: 9606.

Chains: A, C (295 residues)

9et6

Cdk2-cyclin a in complex with fraglite 7

Source: Bos taurus. Cattle. Organism_taxid: 9913. Gene: ccna2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Homo sapiens. Human. Organism_taxid: 9606.

Chains: A, C (302 residues)

9et7

Cdk2-cyclin a in complex with fraglite 6

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Bos taurus. Cattle. Organism_taxid: 9913.

Chains: A, C (293 residues)

9et8

Cdk2-cyclin a in complex with fraglite 5

Source: Bos taurus. Cattle. Organism_taxid: 9913. Gene: ccna2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Homo sapiens. Human. Organism_taxid: 9606.

Chains: A, C (302 residues)

9et9

Cdk2-cyclin a in complex with fraglite 4

Source: Bos taurus. Cattle. Organism_taxid: 9913. Gene: ccna2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Homo sapiens. Human. Organism_taxid: 9606.

Chains: A, C (297 residues)

9eta

Cdk2-cyclin a in complex with fraglite 3

Source: Bos taurus. Cattle. Organism_taxid: 9913. Gene: ccna2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Homo sapiens. Human. Organism_taxid: 9606.

Chains: A, C (302 residues)

9etb

Cdk2-cyclin a in complex with fraglite 2

Source: Bos taurus. Cattle. Organism_taxid: 9913. Gene: ccna2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Homo sapiens. Human. Organism_taxid: 9606.

Chains: A, C (301 residues)

9etp

Cdk2-cyclin a in complex with fraglite 1

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Bos taurus. Cattle. Organism_taxid: 9913.

Chains: A, C (297 residues)

9fmr

Structure of ddb1/cdk12/cyclin k with molecular glue sr-4835

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ddb1, xap1. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Gene: cdk12, crk7, crkrs, kiaa0904. Gene: ccnk, cpr4. Expression_system_taxid: 7108

Chains: B, E, H (335 residues)

9gla

Crystal structure of a cdk2-based cdk7 mimic with inhibitor sy5609

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Gene: ccna2, ccn1, ccna. Expression_system_taxid: 469008

Chain: A (292 residues)

9hiu

Cryo-em structure of cdk2-cyclin a bound to a gmnc peptide

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ccna2, ccn1, ccna. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: cdk2, cdkn2. Synthetic: yes. Organism_taxid: 9606

Chain: B (285 residues)

9hiw

Cryo-em structure of cdk2-cyclin a bound to a samhd1 peptide

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ccna2, ccn1, ccna. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: cdk2, cdkn2. Synthetic: yes. Organism_taxid: 9606

Chain: B (285 residues)

9hix

Cryo-em structure of cak (cdk7 d97n mutant) in complex with thz1

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mnat1, cap35, mat1, rnf66. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: ccnh. Gene: cdk7, cak, cak1, cdkn7, mo15, stk1. Expression_system_taxid: 7111

Chain: J (284 residues)

9hiy

Cryo-em structure of cak (cdk7 d97n mutant) in complex with atpgs

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mnat1, cap35, mat1, rnf66. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: ccnh. Gene: cdk7, cak, cak1, cdkn7, mo15, stk1. Expression_system_taxid: 7111

Chain: J (287 residues)

9hj0

Cryo-em structure of cak (cdk7 d97n mutant) in complex with samuraciclib

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mnat1, cap35, mat1, rnf66. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: ccnh. Gene: cdk7, cak, cak1, cdkn7, mo15, stk1. Expression_system_taxid: 7111

Chain: J (280 residues)

9hj1

Cryo-em structure of cdk2-cyclin a bound to a scaper peptide

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ccna2, ccn1, ccna. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: cdk2, cdkn2. Synthetic: yes. Organism_taxid: 9606

Chain: B (285 residues)

9i9i

Cryo-em structure of cak-cdk11

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk11b, cdc2l1, cdk11, pitslrea, pk58. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: mnat1, cap35, mat1, rnf66. Gene: ccnh. Gene: cdk7, cak, cak1, cdkn7, mo15, stk1.

Chain: K (268 residues)

Bound ligands: Het Group ADP corresponds to enzyme product ADP

Het Group ADP corresponds to enzyme product ADP

9i9j

Cryo-em structure of cak-cdk2 (determined in the presence of adp- nitrate)

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mnat1, cap35, mat1, rnf66. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: ccnh. Gene: cdk7, cak, cak1, cdkn7, mo15, stk1. Gene: cdk2, cdkn2.

Chain: K (246 residues)

Bound ligands: Het Group ADP corresponds to enzyme product ADP

Het Group ADP corresponds to enzyme product ADP

9i9k

Cryo-em structure of cak-cdk2 (determined in the presence of adp-alfx)

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mnat1, cap35, mat1, rnf66. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: ccnh. Gene: cdk7, cak, cak1, cdkn7, mo15, stk1. Gene: cdk2, cdkn2.

Chain: K (276 residues)

Bound ligands: Het Group ADP corresponds to enzyme product ADP

Het Group ADP corresponds to enzyme product ADP

9qcv

Cryo-em structure of cak-cdk2-cyclin a2 bound to amp-pnp

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cdk2, cdkn2. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: ccna2, ccn1, ccna. Gene: mnat1, cap35, mat1, rnf66. Expressed in: trichoplusia ni.

Chain: K (292 residues)

Bound ligands: Het Group ANP is 81.25% similar to enzyme product ADP

Het Group ANP is 81.25% similar to enzyme product ADP

9qcx

Cryo-em structure of apo-cak-cdk2-cyclin a2

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mnat1, cap35, mat1, rnf66. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: ccnh. Gene: cdk7, cak, cak1, cdkn7, mo15, stk1. Gene: cdk2, cdkn2.

Chain: K (292 residues)

9skq

Cryo-em structure of cak-cdk1-cyclin b1

Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: mnat1, cap35, mat1, rnf66. Expressed in: trichoplusia ni. Expression_system_taxid: 7111. Gene: ccnh. Gene: cdk7, cak, cak1, cdkn7, mo15, stk1. Gene: cdk1, cdc2, cdc28a, cdkn1, p34cdc2.

Chains: ( residues)