PDBsum entry 3nid

Cell adhesion/blood clotting

PDB id: 3nid

Contents

Protein chains

454 a.a. *

466 a.a. *

214 a.a. *

214 a.a. *

Ligands

NAG-NAG-MAN-MAN-MAN

NAG-NAG ×2

NAG-NAG-MAN

GOL ×9

SO4 ×10

NAG ×2

Metals

_CA ×12

_MG ×2

Waters ×1059

* Residue conservation analysis

PDB id:

3nid

Name:

Cell adhesion/blood clotting

Title:

The closed headpiece of integrin alphaiib beta3 and its complex with an alpahiib beta3 -specific antagonist that does not induce opening

Structure:

Integrin alpha-iib. Chain: a, c. Fragment: integrin alpha-iib, residues 32-488. Synonym: platelet membrane glycoprotein iib, gpalpha iib, gpiib, integrin alpha-iib heavy chain. Engineered: yes. Integrin beta-3. Chain: b, d. Fragment: integrin beta-3, residues 27-497.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: itga2b, gp2b, itgab. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: lec 3.2.8.1. Expression_system_cell: cho. Gene: itgb3, gp3a.

Resolution:

2.30Å R-factor: 0.180 R-free: 0.215

Authors:

J.H.Zhu,J.Q.Zhu,T.A.Springer

Key ref:

J.Zhu et al. (2010). Closed headpiece of integrin αIIbβ3 and its complex with an αIIbβ3-specific antagonist that does not induce opening. Blood, 116, 5050-5059. PubMed id: 20679525

Date:

15-Jun-10 Release date: 22-Dec-10

Protein chains

P08514  (ITA2B_HUMAN) -  Integrin alpha-IIb from Homo sapiens

Seq: 1039 a.a.

Struc: 454 a.a.

Protein chains

P05106  (ITB3_HUMAN) -  Integrin beta-3 from Homo sapiens

Seq: 788 a.a.

Struc: 466 a.a.

Protein chains

No UniProt id for this chain

Struc: 214 a.a.

Protein chains

No UniProt id for this chain

Struc: 214 a.a.

Blood 116:5050-5059 (2010)

PubMed id: 20679525

Closed headpiece of integrin αIIbβ3 and its complex with an αIIbβ3-specific antagonist that does not induce opening.

J.Zhu, J.Zhu, A.Negri, D.Provasi, M.Filizola, B.S.Coller, T.A.Springer.

ABSTRACT

No abstract given.