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PDBsum entry 3ey4
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Oxidoreductase
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PDB id
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3ey4
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Contents |
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* Residue conservation analysis
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PDB id:
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| Name: |
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Oxidoreductase
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Title:
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Further studies with the 2-amino-1,3-thiazol-4(5h)-one class of 11- hydroxysteroid dehydrogenase type 1 (11-hsd1) inhibitors: reducing pregnane x receptor (pxr) activity and exploring activity in a monkey pharmacodynamic model
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Structure:
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11-beta-hydroxysteroid dehydrogenase 1. Chain: a, b, c, d. Fragment: dehydrogenase domain. Synonym: corticosteroid 11-beta-dehydrogenase isozyme 1, 11-beta- hsd1, 11-dh. Engineered: yes. Mutation: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: hsd11b1, hsd11, hsd11l. Expressed in: escherichia coli. Expression_system_taxid: 516
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Resolution:
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3.00Å
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R-factor:
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0.219
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R-free:
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0.319
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Authors:
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J.D.Zhang,S.R.Jordan,V.Li
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Key ref:
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F.Christopher
et al.
Further studies with the 2-Amino-1,3-Thiazol-4(5h)-One class of 11-Hydroxysteroid dehydrogenase type 1 (11-Hsd1) inhibitors: reducing pregnane x receptor (pxr) activity and exploring activity in a monkey pharmacodynamic model.
To be published,
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Date:
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17-Oct-08
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Release date:
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11-Nov-08
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PROCHECK
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Headers
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References
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P28845
(DHI1_HUMAN) -
11-beta-hydroxysteroid dehydrogenase 1 from Homo sapiens
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Seq:
Struc:
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292 a.a.
259 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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Enzyme class 1:
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E.C.1.1.1.146
- 11beta-hydroxysteroid dehydrogenase.
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Reaction:
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an 11beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH + H+
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11beta-hydroxysteroid
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+
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NADP(+)
Bound ligand (Het Group name = )
corresponds exactly
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=
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11-oxosteroid
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+
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NADPH
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+
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H(+)
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Enzyme class 2:
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E.C.1.1.1.201
- 7beta-hydroxysteroid dehydrogenase (NADP(+)).
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Reaction:
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a 7beta-hydroxysteroid + NADP+ = a 7-oxosteroid + NADPH + H+
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7beta-hydroxysteroid
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+
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NADP(+)
Bound ligand (Het Group name = )
corresponds exactly
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=
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7-oxosteroid
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+
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NADPH
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+
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H(+)
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Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
