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UniProt functional annotation for P28845 | ||
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| UniProt code: P28845. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone (PubMed:10497248). Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7- ketocholesterol to 7-beta-hydroxycholesterol (By similarity). {ECO:0000250|UniProtKB:Q6R0J2, ECO:0000269|PubMed:10497248}. |
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| Catalytic activity: | |
Reaction=an 11beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + H(+) + NADPH; Xref=Rhea:RHEA:11388, ChEBI:CHEBI:15378, ChEBI:CHEBI:35346, ChEBI:CHEBI:47787, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.1.1.146; Evidence={ECO:0000269|PubMed:10497248, ECO:0000269|PubMed:15152005, ECO:0000269|PubMed:17070044, ECO:0000269|PubMed:17919905}; |
| Catalytic activity: | |
Reaction=corticosterone + NADP(+) = 11-dehydrocorticosterone + H(+) + NADPH; Xref=Rhea:RHEA:42200, ChEBI:CHEBI:15378, ChEBI:CHEBI:16827, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349, ChEBI:CHEBI:78600; Evidence={ECO:0000269|PubMed:10497248}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:42201; Evidence={ECO:0000269|PubMed:10497248}; PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:42202; Evidence={ECO:0000269|PubMed:10497248}; |
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:15513927, ECO:0000269|PubMed:17919905, ECO:0000269|PubMed:18069989, ECO:0000269|PubMed:18485702, ECO:0000269|PubMed:18553955, ECO:0000269|PubMed:19217779}. |
| Subcellular location: | |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:10497248}; Single-pass type II membrane protein {ECO:0000269|PubMed:10497248}. |
| Tissue specificity: | |
Widely expressed. Highest expression in liver. |
| Ptm: | |
Glycosylated. {ECO:0000269|PubMed:10497248, ECO:0000269|PubMed:19159218}. |
| Disease: | |
Cortisone reductase deficiency 2 (CORTRD2) [MIM:614662]: An autosomal dominant error of cortisone metabolism characterized by a failure to regenerate cortisol from cortisone, resulting in increased cortisol clearance, activation of the hypothalamic- pituitary axis and ACTH-mediated adrenal androgen excess. Clinical features include hyperandrogenism resulting in hirsutism, oligo- amenorrhea, and infertility in females and premature pseudopuberty in males. {ECO:0000269|PubMed:12858176}. Note=The disease is caused by variants affecting the gene represented in this entry. |
| Similarity: | |
Belongs to the short-chain dehydrogenases/reductases (SDR) family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.