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PDBsum entry 2eck
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Contents |
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* Residue conservation analysis
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Enzyme class:
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E.C.2.7.4.3
- adenylate kinase.
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Reaction:
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AMP + ATP = 2 ADP
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AMP
Bound ligand (Het Group name = )
corresponds exactly
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+
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ATP
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=
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2
×
ADP
Bound ligand (Het Group name = )
corresponds exactly
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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DOI no:
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Proteins
62:555-556
(2006)
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PubMed id:
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Crystal structure of ADP/AMP complex of Escherichia coli adenylate kinase.
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M.B.Berry,
E.Bae,
T.R.Bilderback,
M.Glaser,
G.N.Phillips.
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ABSTRACT
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Selected figure(s)
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Figure 1.
Figure 1. Close-up view of the active site showing key residues
involved in catalysis. Carbon, nitrogen, oxygen, and phosphorus
atoms are shown in black, blue, red, and purple, respectively.
Potential interactions between the residues and the substrates
are displayed as broken lines.
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The above figure is
reprinted
by permission from John Wiley & Sons, Inc.:
Proteins
(2006,
62,
555-556)
copyright 2006.
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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J.B.Brokaw,
and
J.W.Chu
(2010).
On the roles of substrate binding and hinge unfolding in conformational changes of adenylate kinase.
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Biophys J,
99,
3420-3429.
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S.Yin,
and
J.A.Loo
(2010).
Elucidating the site of protein-ATP binding by top-down mass spectrometry.
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J Am Soc Mass Spectrom,
21,
899-907.
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O.Beckstein,
E.J.Denning,
J.R.Perilla,
and
T.B.Woolf
(2009).
Zipping and unzipping of adenylate kinase: atomistic insights into the ensemble of open<-->closed transitions.
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J Mol Biol,
394,
160-176.
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M.C.Jecklin,
D.Touboul,
C.Bovet,
A.Wortmann,
and
R.Zenobi
(2008).
Which electrospray-based ionization method best reflects protein-ligand interactions found in solution? a comparison of ESI, nanoESI, and ESSI for the determination of dissociation constants with mass spectrometry.
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J Am Soc Mass Spectrom,
19,
332-343.
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N.Kantarci-Carsibasi,
T.Haliloglu,
and
P.Doruker
(2008).
Conformational transition pathways explored by Monte Carlo simulation integrated with collective modes.
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Biophys J,
95,
5862-5873.
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J.A.Hanson,
K.Duderstadt,
L.P.Watkins,
S.Bhattacharyya,
J.Brokaw,
J.W.Chu,
and
H.Yang
(2007).
Illuminating the mechanistic roles of enzyme conformational dynamics.
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Proc Natl Acad Sci U S A,
104,
18055-18060.
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J.S.Salafsky
(2007).
Second-harmonic generation for studying structural motion of biological molecules in real time and space.
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Phys Chem Chem Phys,
9,
5704-5711.
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M.Bellinzoni,
A.Haouz,
M.Graña,
H.Munier-Lehmann,
W.Shepard,
and
P.M.Alzari
(2006).
The crystal structure of Mycobacterium tuberculosis adenylate kinase in complex with two molecules of ADP and Mg2+ supports an associative mechanism for phosphoryl transfer.
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Protein Sci,
15,
1489-1493.
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PDB code:
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
code is
shown on the right.
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Links
