 |
PDBsum entry 2y3a
|
|
|
|
PDB id:
|
|
|
|
| Name: |
|
Transferase
|
|
|
Title:
|
|
Crystal structure of p110beta in complex with icsh2 of p85beta and the drug gdc-0941
|
|
Structure:
|
|
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform. Chain: a. Synonym: pi3-kinase subunit beta, pi3k-beta, ptdins-3-kinase subunit beta, phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kda catalytic subunit beta, ptdins-3-kinase subunit p110-beta, pik3ca. Engineered: yes. Phosphatidylinositol 3-kinase regulatory subunit beta. Chain: b.
|
|
Source:
|
|
Mus musculus. Mouse. Organism_taxid: 10090. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
|
|
Resolution:
|
|
|
3.30Å
|
R-factor:
|
0.237
|
R-free:
|
0.296
|
|
|
Authors:
|
|
X.Zhang,O.Vadas,O.Perisic,R.L.Williams
|
|
Key ref:
|
|
X.Zhang
et al.
(2011).
Structure of lipid kinase p110β/p85β elucidates an unusual SH2-domain-mediated inhibitory mechanism.
Mol Cell,
41,
567-578.
PubMed id:
|
|
|
Date:
|
|
|
20-Dec-10
|
Release date:
|
16-Mar-11
|
|
|
|
|
|
|
PROCHECK
|
|
|
|
|
|
Headers
|
|
|
|
References
|
|
|
|
|
|
|
|
|
|
|
|
Enzyme class 2:
|
|
Chain A:
E.C.2.7.1.153
- phosphatidylinositol-4,5-bisphosphate 3-kinase.
|
|
|
|
|
|
|
Pathway:
|
|
1-Phosphatidyl-myo-inositol Metabolism
|
|
|
|
|
|
Reaction:
|
|
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5- trisphosphate) + ADP + H+
|
|
|
|
|
|
1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)
|
+
|
ATP
|
=
|
1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5- trisphosphate)
|
+
|
ADP
|
+
|
H(+)
|
|
|
|
|
|
|
|
|
|
Enzyme class 3:
|
|
Chain A:
E.C.2.7.11.1
- non-specific serine/threonine protein kinase.
|
|
|
|
|
|
|
Reaction:
|
|
|
1.
|
L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
|
|
2.
|
L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H+
|
|
|
|
|
|
|
L-seryl-[protein]
|
+
|
ATP
|
=
|
O-phospho-L-seryl-[protein]
|
+
|
ADP
|
+
|
H(+)
|
|
|
|
|
|
|
L-threonyl-[protein]
|
+
|
ATP
|
=
|
O-phospho-L-threonyl-[protein]
|
+
|
ADP
|
+
|
H(+)
|
|
|
|
|
|
|
|
|
|
|
|
|
Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
|
|
|
|
Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
| |
|
|
| |
|
|
Mol Cell
41:567-578
(2011)
|
|
PubMed id:
|
|
|
|
|
|
| |
|
Structure of lipid kinase p110β/p85β elucidates an unusual SH2-domain-mediated inhibitory mechanism.
|
|
X.Zhang,
O.Vadas,
O.Perisic,
K.E.Anderson,
J.Clark,
P.T.Hawkins,
L.R.Stephens,
R.L.Williams.
|
|
|
|
|
| |
ABSTRACT
|
|
|
|
| |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
 |
 |
|
Literature references that cite this PDB file's key reference
|
|
|
| |
PubMed id
|
|
Reference
|
|
|
|
|
|
B.Vanhaesebroeck,
L.Stephens,
and
P.Hawkins
(2012).
PI3K signalling: the path to discovery and understanding.
|
| |
Nat Rev Mol Cell Biol,
13,
195-203.
|
|
|
|
|
|
|
P.K.Vogt
(2011).
PI3K p110β: more tightly controlled or constitutively active?
|
| |
Mol Cell,
41,
499-501.
|
|
|
|
|
|
The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
|
|
|
Links
