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Cryo-EM structure of DrBphP in Pr state

Source organism: Deinococcus radiodurans R1 = ATCC 13939 = DSM 20539
Biochemical function: metal ion binding
Biological process: phosphorylation
Cellular component: not assigned

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EC 2.7.13.3: Histidine kinase

Reaction catalysed:
ATP + protein L-histidine = ADP + protein N-phospho-L-histidine
Systematic name:
ATP:protein-L-histidine N-phosphotransferase
Alternative Name(s):
  • EnvZ
  • HK1
  • HP165
  • Histidine protein kinase
  • Protein histidine kinase
  • Protein kinase
  • Protein kinase (histidine)
  • Sln1p

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00072
Domain description: Response regulator receiver domain
Occurring in:
  1. Bacteriophytochrome; Response regulatory domain-containing protein
The deposited structure of PDB entry 8avw contains 2 copies of Pfam domain PF00072 (Response regulator receiver domain) in Bacteriophytochrome. Showing 1 copy in chain B (this domain is out of the observed residue ranges!).

PF02518
Domain description: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Occurring in:
  1. Bacteriophytochrome; Response regulatory domain-containing protein
The deposited structure of PDB entry 8avw contains 2 copies of Pfam domain PF02518 (Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase) in Bacteriophytochrome. Showing 1 copy in chain B (this domain is out of the observed residue ranges!).

PF00360
Domain description: Phytochrome region
Occurring in:
  1. Bacteriophytochrome; Response regulatory domain-containing protein
The deposited structure of PDB entry 8avw contains 2 copies of Pfam domain PF00360 (Phytochrome region) in Bacteriophytochrome. Showing 1 copy in chain B.

PF01590
Domain description: GAF domain
Occurring in:
  1. Bacteriophytochrome; Response regulatory domain-containing protein
The deposited structure of PDB entry 8avw contains 2 copies of Pfam domain PF01590 (GAF domain) in Bacteriophytochrome. Showing 1 copy in chain B.

PF08446
Domain description: PAS fold
Occurring in:
  1. Bacteriophytochrome; Response regulatory domain-containing protein
The deposited structure of PDB entry 8avw contains 2 copies of Pfam domain PF08446 (PAS fold) in Bacteriophytochrome. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR001789
Domain description: Signal transduction response regulator, receiver domain
Occurring in:
  1. Bacteriophytochrome; Response regulatory domain-containing protein
IPR004358
Domain description: Signal transduction histidine kinase-related protein, C-terminal
Occurring in:
  1. Bacteriophytochrome; Response regulatory domain-containing protein
IPR003594
Domain description: Histidine kinase/HSP90-like ATPase
Occurring in:
  1. Bacteriophytochrome; Response regulatory domain-containing protein
IPR036890
Domain description: Histidine kinase/HSP90-like ATPase superfamily
Occurring in:
  1. Bacteriophytochrome; Response regulatory domain-containing protein
IPR003018
Domain description: GAF domain
Occurring in:
  1. Bacteriophytochrome; Response regulatory domain-containing protein
IPR011006
Domain description: CheY-like superfamily
Occurring in:
  1. Bacteriophytochrome; Response regulatory domain-containing protein
IPR005467
Domain description: Histidine kinase domain
Occurring in:
  1. Bacteriophytochrome; Response regulatory domain-containing protein
IPR036097
Domain description: Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily
Occurring in:
  1. Bacteriophytochrome; Response regulatory domain-containing protein
IPR013515
Domain description: Phytochrome, central region
Occurring in:
  1. Bacteriophytochrome; Response regulatory domain-containing protein
IPR043150
Domain description: Phytochrome, PHY domain superfamily
Occurring in:
  1. Bacteriophytochrome; Response regulatory domain-containing protein
IPR016132
Domain description: Phytochrome chromophore attachment domain
Occurring in:
  1. Bacteriophytochrome; Response regulatory domain-containing protein
IPR013654
Domain description: PAS fold-2
Occurring in:
  1. Bacteriophytochrome; Response regulatory domain-containing protein
IPR029016
Domain description: GAF-like domain superfamily
Occurring in:
  1. Bacteriophytochrome; Response regulatory domain-containing protein
IPR035965
Domain description: PAS domain superfamily
Occurring in:
  1. Bacteriophytochrome; Response regulatory domain-containing protein

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