8cte

Electron Microscopy
2.9Å resolution

Class 2 of erythrocyte ankyrin-1 complex (Composite map)

Released:
Source organism: Homo sapiens
Primary publication:
Architecture of the human erythrocyte ankyrin-1 complex.
Nat Struct Mol Biol 29 706-718 (2022)
PMID: 35835865
Related structures: EMD-26988

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetradecamer (preferred)
PDBe Complex ID:
PDB-CPX-136105 (preferred)
Entry contents:
7 distinct polypeptide molecules
Macromolecules (7 distinct):
Ankyrin-1 Chain: A
Molecule details ›
Chain: A
Length: 1881 amino acids
Theoretical weight: 206.52 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P16157 (Residues: 1-1881; Coverage: 100%)
Gene names: ANK, ANK1
Sequence domains:
Band 3 anion transport protein Chains: P, T, W
Molecule details ›
Chains: P, T, W
Length: 911 amino acids
Theoretical weight: 101.88 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02730 (Residues: 1-911; Coverage: 100%)
Gene names: AE1, DI, EPB3, SLC4A1
Sequence domains:
Protein 4.2 Chain: X
Molecule details ›
Chain: X
Length: 691 amino acids
Theoretical weight: 77.1 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P16452 (Residues: 1-691; Coverage: 100%)
Gene names: E42P, EPB42
Sequence domains:
Blood group Rh(CE) polypeptide Chain: K
Molecule details ›
Chain: K
Length: 417 amino acids
Theoretical weight: 45.6 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P18577 (Residues: 1-417; Coverage: 100%)
Gene names: RHC, RHCE, RHE
Sequence domains: Ammonium Transporter Family
Ammonium transporter Rh type A Chains: L, Q
Molecule details ›
Chains: L, Q
Length: 409 amino acids
Theoretical weight: 44.23 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: Q02094 (Residues: 1-409; Coverage: 100%)
Gene names: RH50, RHAG
Sequence domains: Ammonium Transporter Family
Glycophorin-A Chains: D, N
Molecule details ›
Chains: D, N
Length: 150 amino acids
Theoretical weight: 16.35 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P02724 (Residues: 1-150; Coverage: 100%)
Gene names: GPA, GYPA
Sequence domains: Glycophorin A
Aquaporin-1 Chains: M, O, R, S
Molecule details ›
Chains: M, O, R, S
Length: 269 amino acids
Theoretical weight: 28.79 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P29972 (Residues: 1-269; Coverage: 100%)
Gene names: AQP1, CHIP28
Sequence domains: Major intrinsic protein

Ligands and Environments

1 modified residue:

Experiments and Validation Details

Entry percentile scores
Resolution: 2.9Å
Relevant EMDB volumes: EMD-26988