Blood group Rhesus C/E/D polypeptide (IPR002229)

Short name: RhesusRHD

Overlapping homologous superfamilies

Family relationships



Proteins in this group are responsible for the molecular basis of the blood group antigens, surface markers on the outside of the red blood cell membrane. Most of these markers are proteins, but some are carbohydrates attached to lipids or proteins [Reid M.E., Lomas-Francis C. The Blood Group Antigen Facts Book Academic Press, London / San Diego, (1997)]. The RH(CE) polypeptide (Rhesus C/E antigens) and RH(D) polypeptide (Rhesus D antigen) belong to the Rh blood group system and are associated with antigens that include C/c, E/e, D, f, C(e), C(w), C(x), V, E(w), G, Tar, VS, D(w), cE, amongst others.

The Rh (Rhesus) blood group system is important in clinical medicine by virtue of being involved in haemolytic disease of the newborn, transfusion reactions, autoimmune haemolytic anaemias, and haemolytic reactions of nonimmune origin [PMID: 1438298]. The RH locus from RH(D)-positive donors contains 2 homologous structural genes, one of which encodes the D protein that carries the major antigen of the Rh system. Hydropathy analysis of the RhD gene product reveals 13 hydrophobic domains, all of which have been assumed to be transmembrane (TM) [PMID: 1438298].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.