X-ray diffraction
1.87Å resolution

Crystal structure of Omsk hemorrhagic fever virus NS5 MTase (in complex with SAH and GpppA)


Function and Biology Details

Reactions catalysed:
NTP + H(2)O = NDP + phosphate
ATP + H(2)O = ADP + phosphate
Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala.
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Core protein Chain: A
Molecule details ›
Chain: A
Length: 265 amino acids
Theoretical weight: 29.95 KDa
Source organism: Omsk hemorrhagic fever virus
Expression system: Escherichia coli
  • Canonical: C4TPE0 (Residues: 2518-2775; Coverage: 8%)
Sequence domains: FtsJ-like methyltransferase

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P21
Unit cell:
a: 35.182Å b: 90.752Å c: 44.495Å
α: 90° β: 91.13° γ: 90°
R R work R free
0.165 0.164 0.206
Expression system: Escherichia coli