Domain

mRNA cap 0/1 methyltransferase (IPR026490)

Short name: mRNA_cap_0/1_MeTrfase

Overlapping homologous superfamilies

Domain relationships

Description

This entry represents the mRNA cap 0/1 methyltransferase domain found at the N-terminal of non-structural protein 5 (NS5). NS5 is one of the fourteen chains of genome poplyprotein from Flavivirus. NS5 has three activities: The N-terminal domain catalyses both guanine N-7 and ribose 2'-OH methylations during viral cap formation. The C-terminal functions as a RNA-directed RNA polymerase [PMID: 12032088, PMID: 17267492, PMID: 19101564].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004482 mRNA (guanine-N7-)-methyltransferase activity
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles