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14-3-3 sigma with RelA/p65 binding site pS45 and covalently bound TCF521-046

X-ray diffraction
1.2Å resolution
PDB entry 7o3a coloured by chain, front view.
PDB entry 7o3a coloured by chain, side view.
PDB entry 7o3a coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: NF-kappaB DNA-binding transcription factor complex, p65/p65 and 14-3-3 protein sigma
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Multimeric state: hetero tetramer
Accessible surface area: 22027.88 Å2
Buried surface area: 6255.48 Å2
Dissociation area: 1,208.82 Å2
Dissociation energy (ΔGdiss): 5.53 kcal/mol
Dissociation entropy (TΔSdiss): 13.09 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-152152

Macromolecules

14-3-3 protein sigma
Chain: A
Length: 236 amino acids
Theoretical weight: 26.56 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P31947 (Residues: 1-231; Coverage: 93%)
Gene names: HME1, SFN
Pfam: 14-3-3 protein
InterPro:
14-3-3 protein sigma in PDB entry 7o3a, assembly 1, front view.
14-3-3 protein sigma in PDB entry 7o3a, assembly 1, side view.
14-3-3 protein sigma in PDB entry 7o3a, assembly 1, top view.
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Transcription factor p65
Chain: P
Length: 13 amino acids
Theoretical weight: 1.41 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q04206 (Residues: 39-51; Coverage: 2%)
Gene names: NFKB3, RELA
Transcription factor p65 in PDB entry 7o3a, assembly 1, front view.
Transcription factor p65 in PDB entry 7o3a, assembly 1, side view.
Transcription factor p65 in PDB entry 7o3a, assembly 1, top view.
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