PDB 7l4u biological assemblies and structure analysis ‹ Protein Data Bank in Europe (PDBe)

Assemblies

Assembly 1 (preferred)

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Assembly Name: Monoglyceride lipase
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Multimeric state: monomeric

Accessible surface area: 12202.0 Å²

Buried surface area: 144.49 Å²

Dissociation area: 72.24 Å²

Dissociation energy (ΔG^diss): 12.36 kcal/mol

Dissociation entropy (TΔS^diss): -0.82 kcal/mol

Symmetry number: 1

PDBe Complex ID: PDB-CPX-189244

$Monomeric assembly 1 of PDB entry 7l4u coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Monoglyceride lipase;</li> <li class='image_legend_li'>1 copy of (5S)-5-(3-{4-[(2-chloro-4-fluorophenoxy)methyl]piperidin-1-yl}-3-oxopropyl)pyrrolidin-2-one;</li> <li class='image_legend_li'>1 copy of CHLORIDE ION;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 1 of PDB entry 7l4u coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Monoglyceride lipase;</li> <li class='image_legend_li'>1 copy of (5S)-5-(3-{4-[(2-chloro-4-fluorophenoxy)methyl]piperidin-1-yl}-3-oxopropyl)pyrrolidin-2-one;</li> <li class='image_legend_li'>1 copy of CHLORIDE ION;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 1 of PDB entry 7l4u coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Monoglyceride lipase;</li> <li class='image_legend_li'>1 copy of (5S)-5-(3-{4-[(2-chloro-4-fluorophenoxy)methyl]piperidin-1-yl}-3-oxopropyl)pyrrolidin-2-one;</li> <li class='image_legend_li'>1 copy of CHLORIDE ION;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

Assembly 2

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Assembly Name: Monoglyceride lipase
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Multimeric state: monomeric

Accessible surface area: 12440.6 Å²

Buried surface area: 0.0 Å²

Dissociation area: 0 Å²

Dissociation energy (ΔG^diss): 0 kcal/mol

Dissociation entropy (TΔS^diss): 0 kcal/mol

Symmetry number: 1

PDBe Complex ID: PDB-CPX-189244

$Monomeric assembly 2 of PDB entry 7l4u coloured by chemically distinct molecules, front view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Monoglyceride lipase;</li> <li class='image_legend_li'>1 copy of (5S)-5-(3-{4-[(2-chloro-4-fluorophenoxy)methyl]piperidin-1-yl}-3-oxopropyl)pyrrolidin-2-one;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 2 of PDB entry 7l4u coloured by chemically distinct molecules, side view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Monoglyceride lipase;</li> <li class='image_legend_li'>1 copy of (5S)-5-(3-{4-[(2-chloro-4-fluorophenoxy)methyl]piperidin-1-yl}-3-oxopropyl)pyrrolidin-2-one;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

$Monomeric assembly 2 of PDB entry 7l4u coloured by chemically distinct molecules, top view. This structure contains: <ul class='image_legend_ul'><li class='image_legend_li'>1 copy of Monoglyceride lipase;</li> <li class='image_legend_li'>1 copy of (5S)-5-(3-{4-[(2-chloro-4-fluorophenoxy)methyl]piperidin-1-yl}-3-oxopropyl)pyrrolidin-2-one;</li> <li class='image_legend_li'>1 copy of water.</li></ul>}$

Macromolecules

Monoglyceride lipase

Chains: A, B
Length: 320 amino acids
Theoretical weight: 35.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:

Canonical: Q99685 (Residues: 1-303; Coverage: 100%)

Gene name: MGLL
Pfam: Serine aminopeptidase, S33
InterPro:

Alpha/Beta hydrolase fold
Serine aminopeptidase, S33
Alpha/beta hydrolase fold-1

Monoglyceride lipase in PDB entry 7l4u, assembly 1, front view.

Monoglyceride lipase in PDB entry 7l4u, assembly 1, side view.

Monoglyceride lipase in PDB entry 7l4u, assembly 1, top view.

FASTA Sequence


    >pdb|7l4u|A B

MHHHHHHGSENLYFQGSMPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWAPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNSVLPNLSSGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP

PDBe-KB: UniProt Coverage View: Q99685

Molecule details ›

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FASTA (Protein chains A, B)
Archive mmCIF file
Updated mmCIF file
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PDB file (gz)
PDBML
PDBML (ATOM lines)
PDBML (no atoms)
Structure Factors
SIFTS XML file with residue-level mappings

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Similar 3D structures (PDBeFold)
Similar sequences

BLAST Q99685 (UniProt)

Protein Data Bank in Europe

Crystal structure of human monoacylglycerol lipase in complex with compound 1h

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Assemblies

Assembly 1 (preferred)

Assembly 2

Macromolecules

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PDBe › 7l4u › Structure analysis

Crystal structure of human monoacylglycerol lipase in complex with compound 1h

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Assemblies

Assembly 1 (preferred)

Assembly 2

Macromolecules

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7l4u › Structure analysis