› 7cfi

X-ray diffraction
2.45Å resolution

Structure of the CBS domain of the bacterial CNNM/CorC family Mg2+ transporter in complex with ATP

Released:
DOI: 10.2210/pdb7cfi/pdb
PDB entry 7cfi coloured by chain, front view.
PDB entry 7cfi coloured by chain, side view.
PDB entry 7cfi coloured by chain, top view.
Source organism: Thermus parvatiensis
Primary publication:
Structural basis for the Mg2+ recognition and regulation of the CorC Mg2+ transporter.
Huang Y, Jin F, Funato Y, Xu Z, Zhu W, Wang J, Sun M, Zhao Y, Yu Y, Miki H, Hattori M
Sci Adv 7 (2021)
PMID: 33568487

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-102848 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Hemolysin Chain: A
Molecule details ›
Chain: A
Length: 142 amino acids
Theoretical weight: 16.4 KDa
Source organism: Thermus parvatiensis
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A109QFA5 (Residues: 207-348; Coverage: 34%)
Gene name: AV541_07030
Sequence domains: CBS domain

Ligands and Environments

2 bound ligands:
Ligand ATP 1 x ATP
Ligand MG 2 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL32XU
Spacegroup: F222
Unit cell:
a: 61.89Å b: 87.3Å c: 201.97Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.247 0.245 0.259
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Magnesium: Biochemistry, Nutrition, Detection, and Social Impact of Diseases Linked to Its Deficiency.
Fiorentini et al. (2021)
6 more

1 mention without citation

Identification and mechanistic analysis of an inhibitor of the CorC Mg2+ transporter.
Huang et al. (2021)