7l0j

X-ray diffraction
2.6Å resolution

Structure of AMH bound to AMHR2-ECD

Released:

Function and Biology Details

Reaction catalysed:
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-137307 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Muellerian-inhibiting factor Chain: A
Molecule details ›
Chain: A
Length: 109 amino acids
Theoretical weight: 11.66 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P03971 (Residues: 459-560; Coverage: 19%)
Gene names: AMH, MIF
Sequence domains: Transforming growth factor beta like domain
Anti-Muellerian hormone type-2 receptor Chain: B
Molecule details ›
Chain: B
Length: 111 amino acids
Theoretical weight: 12.19 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q16671 (Residues: 18-124; Coverage: 19%)
Gene names: AMHR, AMHR2, MISR2

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P41212
Unit cell:
a: 66.376Å b: 66.376Å c: 125.922Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.243 0.241 0.268
Expression systems:
  • Cricetulus griseus
  • Spodoptera frugiperda