› 7e58

X-ray diffraction
2.6Å resolution

interferon-inducible anti-viral protein 2

Released:
DOI: 10.2210/pdb7e58/pdb
PDB entry 7e58 coloured by chain, front view.
PDB entry 7e58 coloured by chain, side view.
PDB entry 7e58 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for GTP-induced dimerization and antiviral function of guanylate-binding proteins.
Cui W, Braun E, Wang W, Tang J, Zheng Y, Slater B, Li N, Chen C, Liu Q, Wang B, Li X, Duan Y, Xiao Y, Ti R, Hotter D, Ji X, Zhang L, Cui J, Xiong Y, Sauter D, Wang Z, Kirchhoff F, Yang H
Proc Natl Acad Sci U S A 118 (2021)
PMID: 33876762

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152322 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Guanylate-binding protein 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 591 amino acids
Theoretical weight: 67.32 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P32456 (Residues: 1-591; Coverage: 100%)
Gene name: GBP2
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL18U1
Spacegroup: P212121
Unit cell:
a: 42.207Å b: 124.161Å c: 355.722Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.256 0.255 0.272
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Receptors for Respiratory Syncytial Virus Infection and Host Factors Regulating the Life Cycle of Respiratory Syncytial Virus.
Feng et al. (2022)
1 more

1 mention without citation

Functional cross-species conservation of guanylate-binding proteins in innate immunity.
Schelle et al. (2023)