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Crystal Structure of the OXA-48 Carbapenem-Hydrolyzing Class D beta-Lactamase in Complex with the DBO inhibitor ANT3310

X-ray diffraction
1.85Å resolution
PDB entry 6zxi coloured by chain, front view.
PDB entry 6zxi coloured by chain, side view.
PDB entry 6zxi coloured by chain, top view.
Source organism: Klebsiella pneumoniae
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Beta-lactamase
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Multimeric state: homo dimer
Accessible surface area: 19680.94 Å2
Buried surface area: 2529.52 Å2
Dissociation area: 1,025.96 Å2
Dissociation energy (ΔGdiss): 5.39 kcal/mol
Dissociation entropy (TΔSdiss): 12.21 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-180526

Macromolecules

Beta-lactamase
Chains: A, B
Length: 265 amino acids
Theoretical weight: 30.4 KDa
Source organism: Klebsiella pneumoniae
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6XEC0 (Residues: 1-265; Coverage: 100%)
Gene names: AI2879V1_5232, GJJ21_26815, KPE71T_00045, SAMEA3727706_05517, bla OXA-48, blaOXA-48, bla_4
Pfam: Penicillin binding protein transpeptidase domain
InterPro:
Beta-lactamase in PDB entry 6zxi, assembly 1, front view.
Beta-lactamase in PDB entry 6zxi, assembly 1, side view.
Beta-lactamase in PDB entry 6zxi, assembly 1, top view.
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