6wgj

X-ray diffraction
1.9Å resolution

Fab portion of dupilumab with Crystal Kappa design and no interchain disulfide

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-214258 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Dupilumab Fab heavy chain Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 234 amino acids
Theoretical weight: 25.2 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Dupilumab Fab light chain Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 217 amino acids
Theoretical weight: 23.8 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P21
Unit cell:
a: 108.9Å b: 78.653Å c: 109.301Å
α: 90° β: 91.4° γ: 90°
R-values:
R R work R free
0.238 0.235 0.289
Expression system: Cricetulus griseus