› 6uzy

Electron Microscopy
3.38Å resolution

Cryo-EM structure of Xenopus tropicalis pannexin 1

Released:
DOI: 10.2210/pdb6uzy/pdb
PDB entry 6uzy coloured by chain, front view.
PDB entry 6uzy coloured by chain, side view.
PDB entry 6uzy coloured by chain, top view.
Source organism: Xenopus tropicalis
Primary publication:
Cryo-EM structures of the ATP release channel pannexin 1.
Deng Z, He Z, Maksaev G, Bitter RM, Rau M, Fitzpatrick JAJ, Yuan P
Nat Struct Mol Biol 27 373-381 (2020)
PMID: 32231289
Related structures: EMD-20964

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo heptamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-109811 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pannexin Chains: A, B, C, D, E, F, G
Molecule details ›
Chains: A, B, C, D, E, F, G
Length: 437 amino acids
Theoretical weight: 49.74 KDa
Source organism: Xenopus tropicalis
Expression system: Komagataella pastoris
UniProt:
  • Canonical: B3DLA5 (Residues: 1-428; Coverage: 100%)
Gene names: LOC100170473, PANX, mrs1, pannexin1, panx1, px1
Sequence domains: Innexin

Ligands and Environments

2 bound ligands:
Ligand 6OU 7 x 6OU
Ligand R16 14 x R16
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.38Å
Relevant EMDB volumes: EMD-20964
Expression system: Komagataella pastoris

Quick links

Citations

16 review citations

Neural versus alternative integrative systems: molecular insights into origins of neurotransmitters.
Moroz et al. (2021)
15 more

2 mentions without citation

On the molecular nature of large-pore channels.
Syrjanen et al. (2021)
1 more