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Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain in complex with 7-(3-(Aminomethyl)-4-(pyridin-3-ylmethoxy)phenyl)-4-methylquinolin-2-amine

X-ray diffraction
1.809Å resolution
PDB entry 6poa coloured by chain, front view.
PDB entry 6poa coloured by chain, side view.
PDB entry 6poa coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Nitric oxide synthase 1
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Multimeric state: homo dimer
Accessible surface area: 33786.28 Å2
Buried surface area: 9778.84 Å2
Dissociation area: 68.41 Å2
Dissociation energy (ΔGdiss): 40.72 kcal/mol
Dissociation entropy (TΔSdiss): -0.2 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-151514

Macromolecules

Nitric oxide synthase 1
Chains: A, B
Length: 421 amino acids
Theoretical weight: 48.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P29475 (Residues: 302-722; Coverage: 29%)
Gene name: NOS1
Pfam: Nitric oxide synthase, oxygenase domain
InterPro:
Nitric oxide synthase 1 in PDB entry 6poa, assembly 1, front view.
Nitric oxide synthase 1 in PDB entry 6poa, assembly 1, side view.
Nitric oxide synthase 1 in PDB entry 6poa, assembly 1, top view.
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